Epigenetic Principles of Evolution - 2nd Edition - ISBN: 9780128140673

Epigenetic Principles of Evolution

2nd Edition

Authors: Nelson Cabej
Paperback ISBN: 9780128140673
Imprint: Academic Press
Published Date: 1st October 2018
Page Count: 656
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Epigenetic Principles of Evolution, Second Edition fully examines the causal basis of evolution from an epigenetic point-of-view. By revealing the epigenetic "user" of the "genetic toolkit", this work demonstrates the primacy of epigenetic mechanisms and epigenetic information in generating evolutionary novelties.

The author convincingly supports his theoretical perspective with a host of examples from varied fields of biology, emphasizing changes in developmental pathways as the basic source of evolutionary change in metazoans. The book therefore provides a broader view of epigenetic mechanisms of evolution, moving beyond conventional changes in epigenetic structures such as DNA methylation, histone modifications, and patterns of miRNA, sRNA, and mRNA expression.

This second edition is thoroughly updated to reflect new evidence, as well as developing theories in the field of evolutionary epigenetics. New and revised chapters speak to the epigenetic basis of heredity, epigenetic regulation of animal structure and homeostasis, neural manipulation of gene expression, central control of gametogenesis, epigenetic control of early development, the origin of epigenetic information, evolutionary changes in response to environmental stressors, epigenetics of sympatric evolution, and epigenetics of the Cambrian explosion among other topics.

Key Features

  • Adopts an integrative approach to examine the causal basis of evolution from an epigenetic point-of-view, with the aim of overcoming current difficulties in the theory of evolution
  • Features all new and revised chapters which reflect novel experimental and observational evidence in the field of evolutionary epigenetics, as well as alternative theoretical approaches
  • Offers a broad view of epigenetic mechanisms of evolution, moving beyond conventional changes in epigenetic mechanisms such as DNA methylation, histone modifications, and patterns of miRNA, sRNA, and mRNA expression


Evolutionary biologists, evolutionary geneticists, developmental biologists, biology graduates and post-graduates, palaeontologists, ecologists; physicians, clinicians, residents, postdocs, and graduate students in genetic and genomic medicine

Table of Contents

Part One - Epigenetic Basis of Heredity
1. Biological Information and Epigenetic Regulation of Animal Structure and Homeostasis
2. Neural Manipulation of Gene Expression
3. Central Control of Gametogenesis
4. Epigenetic Control of Early Development
5. Neural Control of Post-phylotypic Development
6. The Origin of Epigenetic Information and the Mechanisms of the Epigenetic Inheritance

Part Two - Neural-Developmental Basis of Evolutionary Adaptation
7. Evolutionary Changes and Stress Response to Changes in Environment
8. Intragenerational Developmental Plasticity in Nature
9. Behavioral Adaptation and Evolution of Innate Behaviors
10. Ontogeny: The Workshop of Evolutionary Change

Part Three – Epigenetics of Circumevolutionary Phenomena and the Mechanism of the Evolutionary Change
11. Transgenerational Inheritance in Nature
12. Experimental Transgenerational Inheritance

Part Four – Epigenetic Modes of Metazoan Evolution
13. Origins of Evolutionary Novelties and Innovations
14. Evolution by Loss
15. Evolution by Reverting to Ancestral Characters
16. The Role of Neural Crest in Vertebrate in Evolution
17. Allopatric Speciation in Animal Evolution
18. Epigenetics of Sympatric Evolution
19. Epigenetics of the Cambrian Explosion


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© Academic Press 2019
Academic Press
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About the Author

Nelson Cabej

Dr. Nelson R. Cabej is the author of Epigenetic Principles Of Evolution (Elsevier, 2011) and Building The Most Complex Structure On Earth (Elsevier, 2013), in which he examines the role of epigenetic mechanisms in organismal evolution. He has published more than 40 scientific articles and 10 books in English and his native language of Albanian on evolutionary biology, epigenetics, and developmental biology. Dr. Cabej earned his Ph.D. in biology at the University of Tirana, Albania, and presently serves as Researcher in the Department of Biology at the university. He has previously taught biology at William Paterson College, Wayne, N.J, USA.

Affiliations and Expertise

Department of Biology, University of Tirana, Tirana, Albania

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