Epigenetic Cancer Therapy

Epigenetic Cancer Therapy

2nd Edition - April 1, 2023

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  • Editor: Steven Gray
  • Paperback ISBN: 9780323913676

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Description

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, and the potential new discoveries hold to improve our understanding of cancer epigenetics and therapeutics. The book encompasses both large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically. Increasing evidence links pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.

Key Features

  • Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies
  • Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs
  • Fully updated to address new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution
  • Features chapter contributions from leading experts in the field

Readership

Researchers in genetics, molecular biology, oncology, pharmaceutical science, and clinical therapy who are interested in the role of epigenetics in cancer biology or those seeking novel means to treat cancer

Table of Contents

  • 1. Introduction

    Part 1: Introduction and Key Concepts
    2. DNA Methylation and Hydroxymethylation in Cancer
    3. Writers, Readers, and Erasers of Epigenetic Marks
    4. Oncohistones
    5. MicroRNAs, epi-miRNAs and Cancer
    6. Long Noncoding RNAs and Cancer
    7. The Epitranscriptome
    8. Mining the Epigenetic Landscape: Surface Mining or Deep Underground - Alecsandar Milosavljevic
    9: Epigenetics Clocks: Concepts for Carcinogenesis10: Environmental Pollution Epigenetics and Cancer

    Part 2: Epigenetics and Cancer
    11. Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality
    12. Epigenetic Therapy in Lung Cancer
    13. Breast Cancer Epigenetics
    14. Therapeutic Applications of the Prostate Cancer Epigenome
    15. Neuroblastoma

    Part 3: Targeting Aberrant Epigenetics
    16. Nutritional Epigenetic Regulators in the Field of Cancer: New Avenues for Chemopreventive Approaches -
    17. Emerging Epigenetic Therapies- Lysine Methyltransferase/PRC Complex Inhibitors
    18. Inhibitors of Jumonji C-Domain Histone Demethylases
    19. Emerging Epigenetic Therapies: Lysine Acetyltransferase Inhibitors
    20: Histone Deacetylases
    21. Emerging Epigenetic Therapies

    Part 4: Issues to Overcome/Areas of Concern
    22. Genetic Intratumoral Heterogeneity
    23. Challenges for single cell epigenetic analysis
    24. Epigenetics Underpinning DNA Damage Repair
    25. Epigenetics of Cisplatin Resistance
    26. Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells

    Part 5: Future Directions: Translation to the Clinic
    27. Personalized Epigenetic Therapy-Chemosensitivity Testing
    28. Personalized Therapy-Epigenetic Profiling as Predictors of Prognosis and Response
    29. Epigenetic Priming - Fact or Fallacy
    30. CRISPR and epigenetics
    31. Epigenetics and CAR-T 

Product details

  • No. of pages: 765
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: April 1, 2023
  • Imprint: Academic Press
  • Paperback ISBN: 9780323913676

About the Editor

Steven Gray

Steven Gray is a Senior Clinical Scientist and Adjunct Assistant Professor in the Thoracic Oncology Research Group, Trinity Centre for Health Sciences at St. James's Hospital, Dublin, Ireland.

Affiliations and Expertise

Senior Clinical Scientist and Adjunct Assistant Professor, Thoracic Oncology Research Group, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland

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