Epidemiology and Medical Statistics

Epidemiology and Medical Statistics

1st Edition - November 6, 2007

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  • Editors: C.R. Rao, J. Miller, D.C. Rao
  • eBook ISBN: 9780080554211
  • Hardcover ISBN: 9780444528018

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This volume, representing a compilation of authoritative reviews on a multitude of uses of statistics in epidemiology and medical statistics written by internationally renowned experts, is addressed to statisticians working in biomedical and epidemiological fields who use statistical and quantitative methods in their work. While the use of statistics in these fields has a long and rich history, explosive growth of science in general and clinical and epidemiological sciences in particular have gone through a see of change, spawning the development of new methods and innovative adaptations of standard methods. Since the literature is highly scattered, the Editors have undertaken this humble exercise to document a representative collection of topics of broad interest to diverse users. The volume spans a cross section of standard topics oriented toward users in the current evolving field, as well as special topics in much need which have more recent origins. This volume was prepared especially keeping the applied statisticians in mind, emphasizing applications-oriented methods and techniques, including references to appropriate software when relevant.

Key Features

· Contributors are internationally renowned experts in their respective areas
· Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research
· Methods for assessing Biomarkers, analysis of competing risks
· Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs
· Structural equations modelling and longitudinal data analysis


graduate students

pharmaceutical companies (theoretical and applied statisticians)
statisticians FDA, EPA, etc

Table of Contents

  • 1. Statistical Methods and Challenges in Epidemiology and Biomedical Research (Ross Prentice)
    2. Statistical Inference for Causal Effects, with Emphasis on Applications in Epidemiology and Medical Statistics (Donald Rubin)
    3. Epidemiological Study Designs (Kenneth Rothman, Sander Greenland, Timothy Lash)
    4. Statistical Methods for Assessing Biomarkers and Analyzing Biomarker Data (Stephen Looney and Joseph Hagan)
    5. Linear and Nonlinear Regression Methods in Epidemiology and Biostatistics (Charles McCulloch, David Glidden, Stephen Shiboski, Eric Vittinghoff)
    6. Logistic Regression (Ed Spitznagel)
    7. Count Response Regression Models (Joseph Hilbe and William Greene)
    8. Mixed Models (Matthew Gurka and Lloyd Edwards)
    9. Survival Analysis (John Klein and Meijie Zhang)
    10. A Review of Statistical Analysis for Competing Risks (Melvin Moeschberger, Kevin Tordoff, Nidhi Kochar)
    11. Cluster Analysis (Bill Shannon)
    12. Factor Analysis and Related Methods (Carol Woods and Michael Edwards)
    13. Structural Equations Modeling (Kentaro Hayashi, Peter Bentler, Ke-Hai Yuan)
    14. Statistical Modeling in Biomedical Research: Longitudinal Data Analysis (Chengjie Xiong, Kejun Zhu, Kai Yu, Phil Miller)
    15. Design and Analysis of Cross-Over Trials (Michael Kenward and Byron Jones)
    16. Sequential and Group Sequential Designs in Clinical Trials: Guidelines for Practitioners (Madhu Mazumdar and Heejung Bang)
    17. Early Phase Clinical Trials: Phase I and II (Feng Gao, Kim Trinkaus, Phil Miller)
    18. Definitive Phase III and Phase IV Clinical Trials (Barry Davis and Sarah Baraniuk)
    19. Incomplete Data in Epidemiology and Medical Statistics (Susanne Rassler, Donald Rubin, Elizabeth Zell)
    20. Meta-Analysis (Ed Spitznagel)
    21. The Multiple Comparison Issue in Health Care Research (Lemuel Moye)
    22. Power: Establishing the Optimum Sample Size
    (Richard Zeller and Yan Yan)
    23. Statistical Learning in Medical Data Analysis
    (Grace Wahba)
    24. Evidence-Based Medicine and Medical Decision Making (Dan Mayer)
    25. Estimation of Marginal Regression Models with Multiple Source Predictors (Heather Litman, Nicholas Horton, Bernardo Hernandez, Nan Laird)
    26. Difference Equations with Public Health Applications (Asha Kapadia and Lemuel Moye)
    27. The Bayesian Approach to Experimental Data Analysis (Bruno Lecoutre)

Product details

  • No. of pages: 872
  • Language: English
  • Copyright: © North Holland 2007
  • Published: November 6, 2007
  • Imprint: North Holland
  • eBook ISBN: 9780080554211
  • Hardcover ISBN: 9780444528018

About the Series Volume Editors

C.R. Rao

C.R. Rao
book “Ancient Inhabitants of Jebel Moya” published by the Cambridge Press under the joint authorship of Rao and two anthropologists. On the basis of work done at CU during the two year period, 1946-1948, Rao earned a Ph.D. degree and a few years later Sc.D. degree of CU and the rare honor of life fellowship of Kings College, Cambridge.

He retired from ISI in 1980 at the mandatory age of 60 after working for 40 years during which period he developed ISI as an international center for statistical education and research. He also took an active part in establishing state statistical bureaus to collect local statistics and transmitting them to Central Statistical Organization in New Delhi. Rao played a pivitol role in launching undergraduate and postgraduate courses at ISI. He is the author of 475 research publications and several breakthrough papers contributing to statistical theory and methodology for applications to problems in all areas of human endeavor. There are a number of classical statistical terms named after him, the most popular of which are Cramer-Rao inequality, Rao-Blackwellization, Rao’s Orthogonal arrays used in quality control, Rao’s score test, Rao’s Quadratic Entropy used in ecological work, Rao’s metric and distance which are incorporated in most statistical books.

He is the author of 10 books, of which two important books are, Linear Statistical Inference which is translated into German, Russian, Czec, Polish and Japanese languages,and Statistics and Truth which is translated into, French, German, Japanese, Mainland Chinese, Taiwan Chinese, Turkish and Korean languages.

He directed the research work of 50 students for the Ph.D. degrees who in turn produced 500 Ph.D.’s. Rao received 38 hon. Doctorate degree from universities in 19 countries spanning 6 continents. He received the highest awards in statistics in USA,UK and India: National Medal of Science awarded by the president of USA, Indian National Medal of Science awarded by the Prime Minister of India and the Guy Medal in Gold awarded by the Royal Statistical Society, UK. Rao was a recipient of the first batch of Bhatnagar awards in 1959 for mathematical sciences and and numerous medals in India and abroad from Science Academies. He is a Fellow of Royal Society (FRS),UK, and member of National Academy of Sciences, USA, Lithuania and Europe. In his honor a research Institute named as CRRAO ADVANCED INSTITUTE OF MATHEMATICS, STATISTICS AND COMPUTER SCIENCE was established in the campus of Hyderabad University.

Affiliations and Expertise

University of Hyderabad Campus, India

J. Miller

Affiliations and Expertise

Washington University School of Medicine, St. Louis, MO, USA

D.C. Rao

Affiliations and Expertise

Washington University School of Medicine, St. Louis, MO, USA

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