Eosinophils in Health and Disease

1st Edition

Editors: James Lee Helene Rosenberg
Hardcover ISBN: 9780123943859
eBook ISBN: 9780123946072
Imprint: Academic Press
Published Date: 2nd November 2012
Page Count: 678
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Written and edited by leaders in the field, Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance. Despite an explosion of discovery in this area over the last decade, this is the only up-to-date resource on eosinophils and eosinophilia exists. This full-color volume provides an essential collection of world class information that is a must-have for any immunologist’s workbench or bookshelf.

Key Features

  • The only updated, comprehensive source of information on eosinophils on the market
    • Written by over 80 leaders in the field
    • Holistic view of the subject, including basic science, disease-specific chapters, therapeutic options and emerging areas of research


    Researchers, clinical investigators and advanced students in the fields of immunology, autoimmunity, asthma and allergy research and cell biology.

    Table of Contents






    Chapter 1. Historical Overview and Perspective on the Role of the Eosinophil in Health and Disease


    Paul Ehrlich and the Discovery of the Eosinophil

    Early Days: The Eosinophil and Anaphylaxis

    Eosinophil Granule Proteins and their Properties

    Interleukin-5, Eotaxin, and Eosinophil-Derived Cytokines

    Transgenic and Knockout Mice for the Investigation of Eosinophils

    Eosinophil-Associated Diseases

    Conclusion and Future Perspectives



    Chapter 2. The Evolutionary Origins and Presence of Eosinophils in Extant Species


    Invertebrate Hemocytes

    Vertebrate Eosinophil Granulocytes

    Comparative Eosinophilopoiesis

    So, why Eosinophil Granulocytes?


    Chapter 3. Eosinophil Structure and Cell Surface Receptors

    Chapter 3.1 Introduction

    Chapter 3.2 Eosinophil Ultrastructure

    Chapter 3.3 Eosinophil Receptor Profile

    Chapter 4. Ex Vivo Models for the Study of Eosinophils

    Chapter 4.1 Introduction

    Chapter 4.2 Eosinophil Cell Lines

    Chapter 4.3 Isolation and Manipulation of Eosinophils from Human Peripheral Blood

    Chapter 4.4 Induction of Eosinophilia in Mice and the Isolation of Eosinophils for Ex Vivo Manipulations

    Chapter 4.5 Culture and Characterization of Mouse Bone Marrow-Derived Eosinophils

    Chapter 4.6 Modeling Eosinophil Development Ex Vivo from Human CD34+ Cells

    Chapter 5. Eosinophilopoiesis

    Chapter 5.1 Introduction

    Chapter 5.2 Transcriptional Regulation of Eosinophil Lineage Commitment and Differentiation

    Chapter 5.3 Eosinophil Lineage-Committed Progenitors

    Chapter 5.4 Interleukin-5 and its Receptor Molecules

    Chapter 5.5 Extramedullary


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    Academic Press
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    About the Editor

    James Lee

    Affiliations and Expertise

    Consultant, Division of Pulmonary Medicine, Associate Professor, Department of Biochemistry and Molecular Biology , Distinguished Mayo Clinic Investigator, Mayo Clinic, Scottsdale, Arizona, USA

    Helene Rosenberg

    Affiliations and Expertise

    Senior Investigator and Section Chief, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA