Eosinophil Ultrastructure

Eosinophil Ultrastructure

Atlas of Eosinophil Cell Biology and Pathology

1st Edition - January 4, 2022

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  • Authors: Rossana Melo, Ann Dvorak, Peter Weller
  • eBook ISBN: 9780128137567
  • Hardcover ISBN: 9780323994132

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Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology entirely focuses on eosinophils and their functional roles in inflammation, host defense, and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed under normal, experimental, and pathological conditions. Created to fill a void in the eosinophil literature, the book includes an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is a learning and teaching tool, it is mainly a helpful  resource for researchers to identify distinguishing features and structural changes that arise during studies of human eosinophils. The book also covers the ultrastructure of mouse eosinophils under normal and activation conditions and in the context of representative diseases.

Key Features

  • Gives guidelines to understand the human eosinophils in studies focused on structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology, and inflammatory responses
  • Provides a core of essential knowledge to identify both immature and mature eosinophils
  • Comprises a representative compilation of the eosinophil ultrastructure during biological processes, such as activation and degranulation, mostly under experimental conditions
  • Highlights eosinophil biological processes found in vivo during human diseases, thus providing a link between basic science and clinical aspects
  • Helps identify distinguishing features and structural changes that arise during studies of human eosinophils after isolation from body fluids, while in cultures, or biopsies
  • Explains the ultrastructural organization of mature and immature mouse eosinophils, highlighting the similarities/differences between them and human eosinophils


Researchers in structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology, and inflammatory responses

Table of Contents

  • Cover
  • Title page
  • Table of Contents
  • Copyright
  • About the authors
  • Preface
  • Acknowledgments
  • Abbreviations
  • Section A: The cell biology of human eosinophils
  • Chapter 1: Introduction
  • Abstract
  • References
  • Chapter 2: Mature eosinophils: General morphology
  • Abstract
  • 2.1: Overview
  • 2.2: Nucleus
  • 2.3: Secretory granules
  • 2.4: Lipid bodies (LBs)
  • 2.5: Eosinophil sombrero vesicles (EoSVs)
  • 2.6: Other organelles and structures
  • References
  • Chapter 3: Eosinophils as secretory cells
  • Abstract
  • 3.1: Overview
  • 3.2: Classical and compound exocytosis
  • 3.3: Piecemeal degranulation
  • 3.4: Cytolysis
  • 3.5: Extracellular vesicle production
  • References
  • Chapter 4: Eosinophil activation
  • Abstract
  • 4.1: Overview
  • 4.2: Ultrastructural changes of secretory granules
  • 4.3: EoSV formation
  • 4.4: Lipid body formation
  • 4.5: Shape changes
  • 4.6: Release of extracellular vesicles (EVs)
  • References
  • Chapter 5: Subcellular localization of immune mediators and other proteins
  • Abstract
  • 5.1: Overview
  • 5.2: Major basic protein (MBP)
  • 5.3: Cytokines
  • 5.4: Receptors
  • 5.5: Tetraspanins
  • 5.6: Galectin-10 (Gal-10)
  • 5.7: Enzymes involved in the formation of leukotrienes
  • References
  • Chapter 6: Eosinophil cell death
  • Abstract
  • 6.1: Overview
  • 6.2: Cytolytic morphology: General aspects
  • 6.3: Cytolytic morphology: ETosis
  • 6.4: Apoptotic morphology: General aspects
  • References
  • Chapter 7: Immature eosinophils
  • Abstract
  • 7.1: Overview
  • 7.2: About immature and mature eosinophil granules
  • 7.3: Maturation stages of human eosinophils characterized by TEM
  • References
  • Section B: Eosinophils in human diseases
  • Chapter 8: Eosinophil-associated diseases (EADs)
  • Abstract
  • 8.1: Overview
  • 8.2: Allergic airway diseases
  • 8.3: Skin disorders
  • 8.4: Hypereosinophilic syndromes (HESs)
  • 8.5: Eosinophilic granulomatosis with polyangiitis (EGPA)
  • 8.6: Gastrointestinal disorders
  • 8.7: Infectious diseases
  • 8.8: Tumors
  • 8.9: Ultrastructure of CLCs in eosinophilic diseases
  • References
  • Section C: The cell biology of mouse eosinophils
  • Chapter 9: Ultrastructure of mouse eosinophils
  • Abstract
  • 9.1: Overview
  • 9.2: Mature mouse eosinophils: General morphology
  • 9.3: Immature mouse eosinophils
  • 9.4: Activation and degranulation of mouse eosinophils
  • 9.5: Mice in the context of EADs
  • References
  • References
  • Figure credits
  • Index

Product details

  • No. of pages: 518
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 4, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780128137567
  • Hardcover ISBN: 9780323994132

About the Authors

Rossana Melo

Rossana Melo is a Professor of Cell Biology and Principal Investigator at Federal University of Juiz de Fora (UFJF), Brazil. She earned her MSc and PhD degrees in Cell Biology from the Federal University of Minas Gerais (UFMG), Brazil, and received postdoctoral training from Harvard Medical School, USA. Rossana Melo serves on a number of research committees and programs and has been a distinct Brazilian Researcher at the Conselho Nacional de Desenvolvimento Científico e Tecnológico –CNPq (National Research Council). She is the leader of the Cell Biology Research Group (UFJF/CNPq) and a visiting Scientist/Professor at Beth Israel Deaconess Medical Center/Harvard University. Her areas of interest and expertise include cellular mechanisms involved in inflammation and infectious diseases, intracellular transport, cell secretion and advanced electron microscopic techniques.

Affiliations and Expertise

Professor of Cell Biology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil; Visiting Scientist from 2002 to 2019, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA

Ann Dvorak

Ann M. Dvorak is Professor of Pathology and Specialist in Cell Ultrastructure at Harvard Medical School in the USA.

Affiliations and Expertise

Professor Emerita of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

Peter Weller

Peter F. Weller is Professor of Medicine at Harvard Medical School and Co-Chief, Infectious Disease Division; Vice Chair of Research in the Department of Medicine at Beth Israel Deaconess Medical Center, Boston, MA, USA.

Affiliations and Expertise

William B. Castle Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Professor of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA

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