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Enzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue University, provides a detailed overview of the origin and function of forty enzymes, the chemical details of their active sites, their mechanisms of action, and associated cofactors. The enzymes featured highlight a step forward, along with possible areas of application, thus supporting new research in academic and industrial labs. Each chapter is written in a clear format, including a brief summary of enzyme function and structure, a detailed description of their mechanisms of action and associated co-factors.
Additionally, an introductory chapter describes the relationship between new and evolving experimental approaches (e.g. X-ray crystallography) and recent advances in our knowledge of enzyme active sites and their reaction mechanisms.
- Offers a comprehensive, biochemical understanding of enzyme mechanisms and their reaction sites
- Supports new research in academic, medical and industrial labs, connecting discoveries powered by recent advances in technology and experimental approaches to areas of application
- Features short, carefully structured, actionable chapters on various enzyme classes, thus allowing for easy-use and searchability
Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology; clinician scientists; researchers in industry and pharma
3. Adenosine deaminase
4. Alcohol dehydrogenase
5. Aldehyde dehydrogenase
7. Carbonic anhydrase
8. Carboxypeptidase A
10. Citrate synthase
11. Cytochrome P450cam
12. m5C Cytosine methyltransferase
13. Deoxyribodipyrimidine photolyase
14. Dihydrolipoamide dehydrogenase
15. Dihydrolipoyl transacetylase
16. Farnesyl pyrophosphate synthase
17. Fructose-1,6-bisphosphate aldolase
18. Hepatitis C NS2/3 protease
19. HIV-1 protease
22. Methyl-coenzyme M reductase
23. Methylmalonyl CoenzymeA Mutase
24. Non-heme iron halogenase
25. Peptidylarginine deiminase
26. Peptidylglycine a-hydroxylating monooxygenase
27. Phenylalanine hydroxylase
28. Phosphatidylinositol-specific phospholipase C
29. Protein kinase A
30. Pyruvate carboxylase
31. Pyruvate dehydrogenase
32. Ribonucleotide reductase
33. Ribonuclease A
34. Serine racemase
35. Soluble quinoprotein glucose dehydrogenase
36. Tetrachloroethene reductive dehalogenase
37. Thymidylate synthase
38. 20S Proteasome
39. Uracil-DNA Glycosylase
40. Vanadium-dependent chloroperoxidase
- No. of pages:
- © Academic Press 2021
- 1st March 2021
- Academic Press
- Paperback ISBN:
Harry Morrison, PhD is Emeritus Professor at Purdue University, West Lafayette, IN, USA. He joined the Purdue School of Science in 1963, and has since supervised nearly fifty Ph.D. students, and also served as Dean of the College of Science from 1992-2002. Dr. Morrison was instrumental in increasing the numbers and impact of women faculty in the College of Science. After earning a B.A. from Brandeis University in 1957 and a Ph.D. from Harvard in 1961, Dr. Morrison was a Postdoctoral Researcher at the Swiss Federal Institute in Zurich, Switzerland for two years, and following this was a Research Associate at the University of Wisconsin from 1962-1963. Dr. Morrison has published over 170 papers in peer reviewed journals and has edited two books on bioorganic chemistry.
Emeritus Professor, Bio-organic Chemistry, Purdue University, West Lafayette, IN, USA
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