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Enzyme Active Sites and their Reaction Mechanisms - 1st Edition - ISBN: 9780128210673

Enzyme Active Sites and their Reaction Mechanisms

1st Edition

Author: Harry Morrison
Paperback ISBN: 9780128210673
Imprint: Academic Press
Published Date: 1st March 2021
Page Count: 264
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Description

Enzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue University, provides a detailed overview of the origin and function of forty enzymes, the chemical details of their active sites, their mechanisms of action, and associated cofactors. The enzymes featured highlight a step forward, along with possible areas of application, thus supporting new research in academic and industrial labs. Each chapter is written in a clear format, including a brief summary of enzyme function and structure, a detailed description of their mechanisms of action and associated co-factors.

Additionally, an introductory chapter describes the relationship between new and evolving experimental approaches (e.g. X-ray crystallography) and recent advances in our knowledge of enzyme active sites and their reaction mechanisms.

Key Features

  • Offers a comprehensive, biochemical understanding of enzyme mechanisms and their reaction sites
  • Supports new research in academic, medical and industrial labs, connecting discoveries powered by recent advances in technology and experimental approaches to areas of application
  • Features short, carefully structured, actionable chapters on various enzyme classes, thus allowing for easy-use and searchability

Readership

Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology; clinician scientists; researchers in industry and pharma

Table of Contents

  1. Acetylcholinesterase
    2. Aconitase
    3. Adenosine deaminase
    4. Alcohol dehydrogenase
    5. Aldehyde dehydrogenase
    6. Arginase
    7. Carbonic anhydrase
    8. Carboxypeptidase A
    9. Chymotrypsin
    10. Citrate synthase
    11. Cytochrome P450cam
    12. m5C Cytosine methyltransferase
    13. Deoxyribodipyrimidine photolyase
    14. Dihydrolipoamide dehydrogenase
    15. Dihydrolipoyl transacetylase
    16. Farnesyl pyrophosphate synthase
    17. Fructose-1,6-bisphosphate aldolase
    18. Hepatitis C NS2/3 protease
    19. HIV-1 protease
    20. Indoleamine-Dioxygenase-1
    21. Lysozyme
    22. Methyl-coenzyme M reductase
    23. Methylmalonyl CoenzymeA Mutase
    24. Non-heme iron halogenase
    25. Peptidylarginine deiminase
    26. Peptidylglycine a-hydroxylating monooxygenase
    27. Phenylalanine hydroxylase
    28. Phosphatidylinositol-specific phospholipase C
    29. Protein kinase A
    30. Pyruvate carboxylase
    31. Pyruvate dehydrogenase
    32. Ribonucleotide reductase
    33. Ribonuclease A
    34. Serine racemase
    35. Soluble quinoprotein glucose dehydrogenase
    36. Tetrachloroethene reductive dehalogenase
    37. Thymidylate synthase
    38. 20S Proteasome
    39. Uracil-DNA Glycosylase
    40. Vanadium-dependent chloroperoxidase

Details

No. of pages:
264
Language:
English
Copyright:
© Academic Press 2021
Published:
1st March 2021
Imprint:
Academic Press
Paperback ISBN:
9780128210673

About the Author

Harry Morrison

Harry Morrison, PhD is Emeritus Professor at Purdue University, West Lafayette, IN, USA. He joined the Purdue School of Science in 1963, and has since supervised nearly fifty Ph.D. students, and also served as Dean of the College of Science from 1992-2002. Dr. Morrison was instrumental in increasing the numbers and impact of women faculty in the College of Science. After earning a B.A. from Brandeis University in 1957 and a Ph.D. from Harvard in 1961, Dr. Morrison was a Postdoctoral Researcher at the Swiss Federal Institute in Zurich, Switzerland for two years, and following this was a Research Associate at the University of Wisconsin from 1962-1963. Dr. Morrison has published over 170 papers in peer reviewed journals and has edited two books on bioorganic chemistry.

Affiliations and Expertise

Emeritus Professor, Bio-organic Chemistry, Purdue University, West Lafayette, IN, USA

Ratings and Reviews