Preface. Oxygen availability: sensory systems (M.L. Burleson). Oxygen availability: brain defence mechanisms (G.E. Nilsson). Air-breathing fishes: metabolic biochemistry of the first diving vertebrates (V.M.F. Almeida-Val, P.W. Hochachka). Temperature: enzyme and organelle (T.S. Moerland). Influence of temperature on muscle properties in relation to swimming performance (L.C. Rome). Effects of temperature on cellular ion regulation and membrane transport systems (A.R. Cossins, P.J. Schwarzbaum, W. Wieser). Burnt tuna: a problem of heat inside and out? (C. Watson). The effects of pressure on G protein-coupled signal transduction (J.F. Siebenaller, T.F. Murray). Metabolic potentials of deep-sea fishes: a comparative approach (J.J. Childress, E.V. Thuesen). Temperature, pressure and the sodium pump: the role of homeoviscous adaptation (A. Gibbs). Adaptation to and effects of acid water on the fish gill (S.D. Reid). Biochemical-physiological adaptations of teleosts to highly alkaline, saline lakes (E.M. Danulat). Cellular mechanisms in calcium transport and homeostasis in fish (G. Flik, P.M. Verbost). Biochemistry of fish migration (H. Ueda, K. Yamauchi). Xenobiotics (C.J. Kennedy). Pesticide metabolism and the adverse effects of metabolites on fishes (J. Nemcsók, I. Benedeczky). Biochemical effects of stress (A.D. Pickering, T.G. Pottinger). Estivation: metabolic suppression, mechanisms and models of control (S.C. Land, N.J. Bernier). Species index. Subject Index.