Environment, Chemistry, and metabolism

Environment, Chemistry, and metabolism

1st Edition - January 1, 1978

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  • Editor: Harry Gelboin
  • eBook ISBN: 9780323150569

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Description

Polycyclic Hydrocarbons and Cancer, Volume 1: Environment, Chemistry, and Metabolism brings together information from many diverse disciplines in the environmental, chemical, biological, and medical sciences to provide a comprehensive account of the link between polycyclic aromatic hydrocarbons (PAHs) and cancer. This volume consists of 19 chapters divided into seven sections based on the following themes: Energy Sources; Environmental Occurrence and Monitoring; Tobacco Carcinogenesis; Chemistry, Carcinogenicity, and Theory; Metabolism and Activation; Enzymology; and Pharmacokinetics. The first three chapters focus on the energy sources, occurrence and surveillance, and environmental monitoring of PAHs. The discussion then turns to the link between smoking and cancer; the carcinogenicity of 5-methylchrysene; synthesis and reactions of diol epoxides and related metabolites of carcinogenic hydrocarbons; and enzymes of oxygenation. The final chapter is devoted to the pharmacokinetics of chemically reactive metabolites. This book will be of interest to investigators and educators concerned with scientific aspects of PAH research; government officials and elected representatives as well as industry leaders who must confront and solve the problems related to PAHs; and others in various fields such as chemistry, environmental science, biochemistry and enzymology, pharmacology, molecular and cell biology, and genetics.

Table of Contents


  • List of Contributors

    Preface

    In Memoriam, Madame Pascaline Daudel

    Contents of Volume 2

    Part I Energy Sources

    1 Energy Sources of Polycyclic Aromatic Hydrocarbons

    I. Introduction

    II. Petroleum

    III. Coal

    IV. Oil Shale

    V. Conclusions, Comparisons, Comments

    References

    Part II Environment: Occurrence and Monitoring

    2 Occurrence and Surveillance of Polycyclic Aromatic Hydrocarbons

    I. Introduction

    II. Occurrence of Polycyclic Aromatic Hydrocarbons

    III. Contamination of Food and Water Supplies

    IV. Surveillance Methods

    V. Conclusion

    References

    3 Analytical Methods for Monitoring Polycyclic Aromatic Hydrocarbons in the Environment

    I. Introduction

    II. Multiple PAH Analysis

    III. Major Component Analysis

    IV. Benzo[a]pyrene Analysis

    V. Application of the Analytical Methods to Environmental Survey

    References

    Part III Tobacco Carcinogenesis

    4 Tobacco Carcinogenesis

    I. Introduction

    II. Some Epidemiological Observations

    III. Characteristics of Tobacco Smoke

    IV. Bioassays

    V. Identification of Tumorigenic Agents

    VI. Reduction of Tumorigenicity

    VII. The Less Harmful Cigarette

    VIII. Summary

    References

    5 On the Carcinogenicity of 5-Methylchrysene: Structure-Activity Studies and Metabolism

    I. Introduction

    II. Results and Discussion

    III. Summary

    References

    Note Added in Proof

    Part IV Chemistry, Carcinogenicity, and Theory

    6 Synthesis and Reactions of Diol Epoxides and Related Metabolites of Carcinogenic Hydrocarbons

    I. Introduction

    II. Synthesis of Arene Dihydrodiols

    III. Synthesis of Arene Tetrahydrodiols

    IV. Synthesis and Characterization of Arene Diol Epoxides

    V. Specific Synthetic Procedures

    VI. Resolution of Dihydrodiols and the Synthesis of Optically Active Diol Epoxides

    VII. Reactions of Arene Diol Epoxides

    References

    Note Added in Proof

    7 Synthesis of Carbon-13-Labeled Benzo[a]pyrene Derivatives

    Text

    References

    8 The Bay-Region Theory of Carcinogenesis by Polycyclic Aromatic Hydrocarbons

    I. Introduction

    II. Formulation of the Bay-Region Theory

    III. A Quantum Mechanical Basis for the Bay-Region Theory

    IV. Evidence in Support of the Bay-Region Theory

    V. Conclusion

    References

    Note Added in Proof

    9 Mutagenicity and Carcinogenicity of Benzo[a]Pyrene and Benzo[a]Pyrene Derivatives

    I. Introduction

    II. Mutagenesis

    III. Carcinogenesis

    References

    Note Added in Proof

    Part V Metabolism and Activation

    10 Benzoftfjpyrene Metabolism: Activation and Detoxification

    I. Introduction

    II. Benzo[a]Pyrene Metabolism

    III. Enzymes of Polycyclic Aromatic Hydrocarbon Metabolism

    IV. Assays for Polycyclic Aromatic Hydrocarbon Metabolism

    References

    11 Distribution and Excretion of the Hydrocarbon 3-Methylcholanthrene in the Animal Body

    I. Introduction

    II. Distribution of 3-Methylcholanthrene in Mice

    III. Metabolism of 3-Methylcholanthrene in Organs

    IV. Metabolism of 3-Methylcholanthrene in Perfused Rat Liver

    V. 3-Methylcholanthrene Metabolites in the Excreta

    VI. Distribution and Metabolism of 3-Methylcholanthrene in Fetal Mice

    VII. Tissue Susceptibility and Accumulation of 3-Methylcholanthrene

    References

    12 Electron Spin Resonance Study of the Binding of the 6-Oxybenzo[a]Pyrene Radical and Benzo[a]Pyrene-Semiquinone Radicals with DNA and Polynucleotides

    I. Introduction

    II. Binding of 6-Oxy-BP Radical with DNA and Polynucleotides

    III. Binding of BP-Semiquinone Radicals with DNA and Polynucleotides

    IV. Summary

    References

    13 Benzo[a]Pyrene Metabolism: One-Electron Pathways and the Role of Nuclear Enzymes

    I. One-Electron Redox Cycles Involving Benzo[a]Pyrene Quinone Metabolites

    II. Benzo[a]Pyrene Metabolism in Liver Nuclei from Female Rats

    References

    14 Hydrocarbon-Nitrosamine Pulmonary Syncarcinogenesis: Reciprocal Effects on Metabolism

    I. Introduction

    II. Working Hypothesis

    III. Materials and Methods

    IV. Results

    V. Conclusions

    References

    Part VI Enzymology

    15 The Role of Cytochrome P-450 and the Microsomal Electron Transport System: The Oxidative Metabolism of Benzo[a]Pyrene

    I. Introduction

    II. Microsomes

    III. Microsomal Electron Transport Reactions

    IV. Studies Related to the Organization of Microsomal Electron Transport Carriers within the Microsomal Membrane

    V. The Cyclic Function of Cytochrome Ρ-450

    VI. The Oxidative Metabolism of Benzo[a]Pyrene

    VII. Substrate Orientation: A General Hypothesis

    VIII. Conclusion

    References

    16 Enzymes of Oxygenation

    I. Introduction

    II. Classification of Oxygenases

    III. Dioxygenases

    IV. Monooxygenases

    V. Electronic Structure of Cytochrome Ρ-450

    References

    17 Biochemical Studies on Chemical Carcinogenesis: Role of Multiple Forms of Liver Microsomal Cytochrome P-450 in the Metabolism of Benzo[a]pyrene and Other Foreign Compounds

    I. Introduction

    II. Experimental Procedures

    III. Results and Discussion

    IV. Summary

    References

    18 Affinity Chromatography of Microsomal Enzymes and Interaction of Activated Estrogens with Nucleic Acids

    I. Introduction

    II. Materials and Methods

    III. Results and Discussion

    References

    Part VII Pharmacokinetics

    19 Pharmacokinetic Aspects of the Formation and Inactivation of Chemically Reactive Metabolites

    I. Introduction

    II. Pharmacokinetics of a Single Reactive Metabolite Reacting with a Single Pool of DNA

    ΠΙ. Pharmacokinetics of Covalent Binding of Reactive Metabolites in Several Tissues

    IV. Application of Pharmacokinetic Principles to in Vitro Experiments

    References

    Subject Index

Product details

  • No. of pages: 432
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 1, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323150569

About the Editor

Harry Gelboin

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