Engineered Nanostructures for Therapeutics and Biomedical Applications

1st Edition - August 31, 2022
Editors: Ajeet Kumar Kaushik, Sandeep Kumar, Ganga Ram Chaudhary
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 2 4 0 - 0
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 2 2 1 - 7

Engineered Nanostructures for Therapeutics and Biomedical Applications offers a single reference for a diverse biomedical readership to learn about the application of nanotechn… Read more

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Engineered Nanostructures for Therapeutics and Biomedical Applications offers a single reference for a diverse biomedical readership to learn about the application of nanotechnology in biomedicine and biomedical engineering, from past developments to current research and future prospects. This book sets out a broad selection of biomedical and therapeutic applications for nanostructures, including bioimaging, nanorobotics, orthopedics, and tissue engineering, offering a useful, multidisciplinary approach. Each chapter discusses challenges faced in each discipline, including limiting factors, biocompatibility, and toxicity, thus enabling the reader to make informed decisions in their research.

This book is a comprehensive, broad overview of the role and significance of nanomaterials and their composites that also includes discussions of key aspects in the field of biomedicine. It will be of significant interest to academics and researchers in materials science and engineering, biomedicine and biomedical engineering, chemical engineering, pharmaceutics, bioimaging, and nanorobotics.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
1. Engineered nanostructures: an introduction
Abstract
1.1 Introduction
1.2 Role of nanotechnology in medical science
1.3 Types of nanostructures for medical applications
1.4 Shape controlled engineered (hybrid) nanostructures for biomedical applications
1.5 Challenges of therapeutic and biomedical applications
1.6 Conclusions
Acknowledgment
References
2. Fluorescent inorganic nanoparticles for bioimaging and therapeutic applications
Abstract
2.1 Introduction
2.2 Fluorescent inorganic nanoparticles
2.3 Fluorescent inorganic nanoparticles in bioimaging
2.4 Fluorescent inorganic nanoparticles in therapy
2.5 Conclusions
Acknowledgments
References
3. Quantum dots and conjugated metal-organic frameworks for targeted drug delivery and bioimaging of cancer
Abstract
3.1 Introduction
3.2 Mechanics of quantum dot: A general architecture
3.3 Metal-organic framework: a dynamic coordination polymer
3.4 Designing strategy for QD@MOF nanocomposites
3.5 Different characterization techniques
3.6 Potential of QD@MOF composite for drug delivery
3.7 Multifunctional QD@MOF composites for bioimaging applications
3.8 Conclusion and future perspectives
Acknowledgment
References
4. Carbon-based nanogels as a synergistic platform for bioimaging and drug delivery
Abstract
4.1 Introduction
4.2 Properties of C-hNgs
4.3 Classification of C-hNgs
4.4 Synthesis of carbon nanomaterial-functionalized carbon-based nanogels
4.5 Conclusion
References
5. Graphene oxides and derivatives for biomedical applications: drug delivery/gene delivery, bioimaging, and therapeutics
Abstract
5.1 Introduction
5.2 Graphene oxide and its derivatives
5.3 Characterization of graphene oxide
5.4 Derivatives of graphene oxide
5.5 Drug delivery/gene delivery
5.6 Bioimaging
5.7 Graphene-based nanomaterials in bioimaging
5.8 Theranostics
5.9 Conclusion
References
6. Self-assembled polymeric nanostructures: a promising platform for bioimaging and therapeutic applications
Abstract
6.1 Introduction
6.2 What is self-assembly?
6.3 Self-assembled polymeric nanostructures (SAPNs)
References
7. Nanofibrous scaffolds for tissue engineering processes
Abstract
7.1 Introduction
7.2 Self-assembly
7.3 Electrospinning
7.4 Phase separation
7.5 Perspective and future directions
Acknowledgment
References
8. Design and testing of nanobiomaterials for orthopedic implants
Abstract
Abbreviations
8.1 Introduction
8.2 Role of nanobiomaterials for orthopedic implants
8.3 Nanotechnology for tissue-engineered bones and nanoscaffolds for improved bone grafts and implants
8.4 Spinal implants
8.5 Nanotechnology for fracture repair (internal fixation devices)
8.6 Nanotechnology for arthoplasty
8.7 Nanomaterials modified orthopedic implants for prevention of orthopedic infections
8.8 Nanotechnology driven implants for anticancer application in orthopedics
8.9 Future scopes and challenges
References
9. Drug-releasing nano-bioimplants: from basics to current progress
Abstract
9.1 Introduction
9.2 Classification of nano-bioimplants
9.3 Processing and characterization of bio-implants
9.4 Applications of nano-bioimplants
9.5 Impact of nano-bioimplants
9.6 Recent trends and challenges in nano-bioimplants
9.7 Future aspects of nano-bioimplants
9.8 Conclusion
References
10. Mobile nanorobotics for biomedical applications
Abstract
10.1 Introduction
10.2 Nanorobots in diagnosis/sensing and detoxification
10.3 Nanorobots in drug delivery
10.4 Nanorobots in surgery
10.5 Biomolecular nanorobots
10.6 Conclusion, gaps, and future prospects
Acknowledgment
References
11. Opportunities, challenges, and future prospects of engineered nanostructures for therapeutics and biomedical applications
Abstract
11.1 Nanobiotechnology and nanomedicine—a success story
11.2 Pitfalls and challenges
11.3 Future of engineered nanostructures in medicine
References
Index

Ajeet Kumar Kaushik

Dr. Ajeet Kaushik is Assistant Professor at the NanoBioTech laboratory, Department of Environmental Engineering, Florida Polytechnic University, USA. He is the recipient of various reputed awards for his service in the area of nano-biotechnology for health care. He has edited four books, written 100 international research peer reviewed publications, and has three patents in the area of nanomedicine and smart biosensors for personalized health care. In the course of his research, Dr. Kaushik has been engaged in design and development of various electro-active nanostructures for electrochemical biosensor and nanomedicine for health care. His research interests include nanobiotechnology, analytical systems, design and develop nanostructures, nano-carries for drug delivery, nano-therapeutics for CNS diseases, on-demand site-specific release of therapeutic agents, exploring personalized nanomedicines, biosensors, point-of-care sensing devices, and related areas of health care monitoring.

Affiliations and expertise

Associate Professor of Chemistry, NanoBioTech Laboratory, Health System Engineering, Department of Environmental Engineering, Florida Polytechnic University, USA

Sandeep Kumar

Dr. Sandeep Kumar is a researcher of international recognition and has received his PhD degree from Panjab University, Chandigarh. His current research interest includes synthesis and characterization of nanomaterials, nano-carriers for healthcare applications; nanomaterials based sensors, biomaterials and nanotoxicity. Dr. Kumar has published more than 150 research papers in international journals of repute and also has patents to his credit. Dr. Kumar has international and national sponsored research projects from numerous funding agencies. Dr. Kumar has been rewarded with “Haryana Yuva Vigyan Ratna Award” and “Water Advanced Research and Innovation Fellow” for undertaking research work at University of Nebraska, Lincoln, USA. Dr. Kumar visited Hanyang University, Seoul, South Korea; University of Florence, Italy as a visiting Professor and also Australia, UK, Scotland, Germany, Spain, France, Belgium etc under different supporting schemes of Govt of India.

Affiliations and expertise

Head of Department, Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, India

Ganga Ram Chaudhary

Dr G R Chaudhary is currently working as Professor at Department of Chemistry, Panjab University, Chandigarh. Dr Chaudhary has focused his research for the past 15 years in emerging research areas of green technologies, novel healthcare formulations, catalysis, nanomaterials-based sensors, molecular recognition/reorganizational behavior and emerging materials for biological applications. The work carried out by Dr Chaudhary in above areas has been published in numerous reputed international journals having high impact factor. Dr Chaudhary is well connected to international research groups with similar research interests.

Affiliations and expertise

Professor, Department of Chemistry & Director, Suphisticated Analytical Instrumentation Facility, Panjab University, Chandigarh, India