Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases
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Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases

1st Edition - October 22, 2021

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  • Editor: Yun Fang
  • Hardcover ISBN: 9780128215197
  • eBook ISBN: 9780128215241

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Description

Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis, Volume 87, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in "Current Topics in Membranes" series
  • Updated release includes the latest information on Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis

Readership

Academic, government and industrial sectors

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Multiscale geometry and mechanics of lipid monolayer collapse
  • Abstract
  • 1: Introduction
  • 2: Methods
  • 3: Experimental results
  • 4: Finite element analysis
  • 5: Multiscale geometry of lipid monolayers
  • 6: Conclusions
  • References
  • Chapter Two: Cardiovascular mechanosensitive ion channels—Translating physical forces into physiological responses
  • Abstract
  • 1: Introduction to mechanosensitive (MS) channels in mammalian systems
  • 2: Mechanosensitive channels in cardiovascular physiology—Overview
  • 3: Mechanosensitive channels in the vasculature
  • 4: Mechanosensitive channels in heart
  • 5: Mechanosensitive channels in baroreceptors
  • 6: Conclusions and perspectives
  • Acknowledgments
  • References
  • Chapter Three: Atorvastatin and blood flow regulate expression of distinctive sets of genes in mouse carotid artery endothelium
  • Abstract
  • 1: Introduction
  • 2: Materials and methods
  • 3: Results
  • 4: Discussion
  • References
  • Chapter Four: Endothelial mechanotransduction in cardiovascular development and regeneration: emerging approaches and animal models
  • Abstract
  • 1: Introduction
  • 2: Zebrafish model of mechanotransduction
  • 3: Mechanoreceptors in cardiac development
  • 4: Conclusion
  • References
  • Chapter Five: “Enhancing” mechanosensing: Enhancers and enhancer-derived long non-coding RNAs in endothelial response to flow
  • Abstract
  • 1: Introduction
  • 2: Flow-responsive EC enhancers
  • 3: Enhancer lncRNAs (elncRNAs) as flow-responsive elements in ECs
  • 4: Conclusion and perspective
  • Acknowledgment
  • References
  • Chapter Six: SWI/SNF (BAF) complexes: From framework to a functional role in endothelial mechanotransduction
  • Abstract
  • 1: Introduction
  • 2: Mechanotransduction and BAF complex
  • 3: Future perspective
  • References
  • Chapter Seven: Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes
  • Abstract
  • 1: Introduction
  • 2: Macrovascular flow and metabolism
  • 3: Microvasculature flow and metabolism
  • 4: Stretch and metabolism
  • 5: Stiffness and endothelial cell metabolism
  • 6: Cytoskeletal regulation of metabolism
  • 7: Discussion
  • References
  • Chapter Eight: Therapeutic perspectives of extracellular vesicles and extracellular microRNAs in atherosclerosis
  • Abstract
  • 1: Introduction
  • 2: Overview of extracellular vesicles
  • 3: Engineered EVs as delivery vehicles
  • 4: Applications of EVs in treating cardiovascular pathologies
  • 5: Extracellular miRNAs in atherosclerosis
  • 6: Conclusion
  • Acknowledgment
  • References
  • Chapter Nine: Mechanotransduction in fibrosis: Mechanisms and treatment targets
  • Abstract
  • 1: Introduction
  • 2: Tissue repair and fibrosis
  • 3: Cell mechanoresponses relevant to fibrosis
  • 4: Mechanotransduction through nucleo-cytoskeletal coupling
  • 5: Biochemical signaling of mechanotransduction
  • 6: Role of YAP/TAZ on mechanotransduction and fibrosis
  • 7: Role of TGF-β on mechanotransduction and fibrosis
  • 8: Role of MRTF on mechanotransduction and fibrosis
  • 9: Epigenetic regulator
  • 10: EMT and EndoMT
  • 11: Treatment target
  • 12: Regulation of matrix stiffness and stability
  • 13: Nuclear regulators (MRTFA, YAP, TAZ)
  • 14: Matrix metalloproteinases (MMPs)
  • 15: TGF-β related integrins
  • 16: Conclusion
  • References

Product details

  • No. of pages: 330
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: October 22, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128215197
  • eBook ISBN: 9780128215241

About the Serial Volume Editor

Yun Fang

Yun Fang works in the Section of Pulmonary and Critical Care, Department of Medicine Biological Sciences Division, College University of Chicago.

Affiliations and Expertise

Section of Pulmonary and Critical Care, Department of Medicine Biological Sciences Division, College University of Chicago

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