Endocrinology of the Heart in Health and Disease

Endocrinology of the Heart in Health and Disease

Integrated, Cellular, and Molecular Endocrinology of the Heart

1st Edition - October 19, 2016

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  • Editors: Jonathan Schisler, Charles Lang, Monte Willis
  • Hardcover ISBN: 9780128031117
  • eBook ISBN: 9780128031124

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Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology.

Key Features

  • Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease
  • Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically
  • Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology


Graduate students and post-docs in cellular and molecular endocrinology and cardiology, pathology, genetics; residents and fellows in endocrinology, cardiology, pathology, laboratory medicine, and internal medicine

Table of Contents

    • Dedication
    • List of Contributors
    • Foreword
    • Preface
      • The Heart as an Endocrine Organ
      • The Heart as an Endocrine Target
    • Acknowledgments
    • Part I: The Heart as an Endocrine Organ
      • Chapter 1. Cardiac Natriuretic Peptides
        • Abstract
        • Historical Perspective
        • Gene Structure of Natriuretic Peptides
        • Translation, Processing, and Storage of Cardiac Natriuretic Peptides
        • Circulating Concentrations, Forms, and Metabolism of Natriuretic Peptides
        • Circulating Natriuretic Peptide Signal Peptides
        • Assays Measuring Natriuretic Peptides in the Circulation
        • Bioactivity
        • Natriuretic Peptide as Therapeutic Agents
        • Enhancing Bioactivity
        • Natriuretic Peptides as Biomarkers in Heart Failure
        • References
      • Chapter 2. Adrenomedullin
        • Abstract
        • Introduction
        • Molecular Forms, Structure, and Structure-Activity Relationships of Adrenomedullin
        • The Adrenomedullin Receptor
        • Cardiac Actions of Adrenomedullin
        • Pathophysiological Function of Adrenomedullin in Cardiac Disease
        • Clinical Applications of Adrenomedullin to Cardiac Disease
        • Conclusion
        • References
      • Chapter 3. Endothelin-1 as a Cardiac-Derived Autocrine, Paracrine and Intracrine Factor in Heart Health and Disease
        • Abstract
        • Introduction
        • Cardiac Production of ET-1
        • Cardiac ET-1 Production in Heart Disease
        • Expression of Cardiac ET Receptors
        • Cardiac Effects of ET-1
        • Physiological and Pathophysiological Roles of Cardiac-Derived ET-1: General Concepts
        • Potential Beneficial Effects of ET-1 in Cardiac Function
        • Development of Clinical Strategies aimed at Targeting ET-1
        • Clinical Evaluation of ET Receptor Antagonists for Treating Heart Disease
        • Concluding Comments
        • Acknowledgements
        • References
      • Chapter 4. The Cardiokines: An Expanding Family of the Heart Secretome
        • Abstract
        • Introduction
        • Cellular Components of the Heart Involved in the Cardiac Secretome
        • The Autocrine, Paracrine, and Endocrine Heart: Components of the Cardiac Secretome
        • Growth Factor Generation in the Heart
        • Inflammatory Mediators Generated in the Heart
        • Cardiac Exosomes and miRNA
        • Insight into Future Directions
        • Acknowledgement
        • References
      • Chapter 5. Novel Small Peptide Hormones
        • Abstract
        • Introduction
        • Endocrine Factors Regulating Blood Pressure and Cardiac Function: Neuronostatin and Adropin
        • Novel Adipokines in the Control of Cardiovascular Function: Nesfatin-1 and Omentin
        • Role of Myokines in Cardiovascular Health: Irisin
        • Modulatory Peptides Encoded by Upstream Short Open Reading Frames of Hormone Receptors: PEP7
        • Summary and Conclusions
        • References
    • Part II: The Heart as an Endocrine Target
      • Chapter 6. Gut-Derived Hormones—Cardiac Effects of Ghrelin and Glucagon-Like Peptide-1
        • Abstract
        • Ghrelin
        • Glucagon-Like Peptide-1
        • References
      • Chapter 7. Fat Hormones, Adipokines
        • Abstract
        • Introduction
        • Obesity as a Chronic Proinflammatory State
        • Proinflammatory Adipokines
        • Anti-Inflammatory Adipokines
        • Conclusion
        • References
      • Chapter 8. Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart
        • Abstract
        • Introduction
        • Electrical System of the Heart
        • Sympathetic Nervous System of the Heart
        • Concluding Remarks
        • References
      • Chapter 9. Renin Angiotensin Aldosterone System and Heart Function
        • Abstract
        • The Conventional Renin Angiotensin Aldosterone System
        • RAAS and Heart Cell Communication
        • AT1 Receptor as a Mechanosensor
        • Role of ACE Inhibitors and AT1 Receptor Blockers
        • ACE2/Ang (1-7) /Mas Receptor Axis Activation
        • Local Cardiac RAAS, the Intracrine Component
        • Intracellular Renin Alters Chemical Communication and Metabolic Cooperation
        • Mitochondria, the Nucleus and the Intracrine Renin-Angiotensin System
        • Aldosterone and Mineralocorticoid Receptor
        • New Developments
        • References
      • Chapter 10. Nuclear Receptors and the Adaptive Response of the Heart
        • Abstract
        • Nuclear Receptors: Introduction
        • PGC Coactivators in the Developing and Diseased Heart
        • Estrogen Receptors
        • Estrogen-Related Receptors
        • Glucocorticoid Receptors
        • Mineralocorticoid Receptors
        • Thyroid Hormone Receptors
        • PPAR Family Receptors
        • Emerging and Associated Players
        • Summary
        • References
      • Chapter 11. Adrenergic Receptors
        • Abstract
        • Adrenergic Signaling: Systematic and Updated Overview
        • Sympathetic System and Hypertension
        • Adrenergic Signaling in Heart Failure
        • Pharmacology of Adrenergic Receptor Blockade
        • References
      • Chapter 12. Insulin Signaling in Cardiac Health and Disease
        • Abstract
        • Abbreviations
        • Introduction
        • Functional Importance of Insulin Receptor Signaling in the Heart
        • Metabolic Effects of Insulin Signaling in the Myocardium
        • Cardiac Insulin Signaling During Obesity and Type 2 Diabetes
        • Insulin Signaling and Cardiac Hypertrophy
        • Cardio-Protective Role of Insulin Signaling in Ischemia Reperfusion and Contractile Failure
        • Scope and Future Perspectives
        • References
    • Index

Product details

  • No. of pages: 378
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: October 19, 2016
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128031117
  • eBook ISBN: 9780128031124

About the Editors

Jonathan Schisler

Jonathan Schisler has experience in studying metabolism, gene expression signatures, and ubiquitin ligases over the past 14 years. His expertise lies in integration of complex genomic-biologic data to elucidate risk relationships in both murine and human systems with a focus on cardiovascular disease and protein quality control mechanisms. His primary focus is to develop models to integrate datasets derived from clinical genomics, transcriptomics, and metabolomics allowing our lab to further interrogate gene and protein function in health and disease using molecular, cellular and biochemical approaches.

Affiliations and Expertise

University of North Carolina School of Medicine, Chapel Hill, NC USA

Charles Lang

Charles Lang
Charles H. Lang, PhD, is currently a Distinguished University Professor in the Department of Cellular and Molecular Physiology, and Professor of Surgery at the Penn State College of Medicine (Hershey, PA). He is also the Associate Dean for Graduate Studies. His research has focused on the mechanisms underlying changes in glucose and protein metabolism in skeletal and cardiac muscle, and the role of cytokines in the regulation of the insulin-like growth factor system in regulating muscle metabolism. He has worked extensively on the regulation of translational control of protein synthesis and the development of anabolic resistance during various catabolic states, including sepsis, thermal injury, disuse atrophy, alcoholism and HIV infection. Dr. Lang received his PhD from Hahnemann Medical College and did his NRSA-supported fellowship at LSU Medical Center in New Orleans. Before joining Penn State University, he was Director of Surgical Research at SUNY-Stony Brook. Dr. Lang has been continuously funded by the NIH for 30 years and is the current recipient of an NIH MERIT Award from NIAAA. He has been a permanent member of 2 NIH study sections: Surgery, Anesthesiology and Trauma, and Alcohol and Toxicology IV, and is currently the Chair of the AA-1 study section at NIH. Dr. Lang is currently the Editor-in-Chief of the American Journal of Physiology: Endocrinology and Metabolism and on the board for numerous other journals. He is a member of more than ten professional societies. He has served in leadership roles in national scientific organizations as exemplified by his term as President for the Shock Society. Dr. Lang has published more than 300 peer-reviewed articles related to altered muscle metabolism during sepsis, alcohol and catabolic illness, and trained more than 20 postdoctoral fellows, surgical residents and graduate students.

Affiliations and Expertise

Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA

Monte Willis

Monte Willis
Monte S. Willis, MD, PhD, MBA is Vice-Chair of Academic Affairs and Associate Professor in the Department of Pathology and Laboratory Medicine at the Univeristy of North Carolina-Chapel Hill. He is Director of Campus Health Services Laboratory and the McLendon Clinical Laboratories and principal investigator in the McAllister Heart Institute, where he leads a research team studying the role of the ubiquitin proteasome system in metabolism and the pathophysiology of cardiac disease (supported by NIH and the Fondation Leducq) and teaches in the School of Medicine and Graduate School. Dr. Willis received his combined MD and PhD training at the University of Nebraska Medical Center. He went on to complete a residency in the Department of Pathology and post-doctoral training in in Burns, Trauma, and Critical Care in the Department of Surgery at the University of Texas Southwestern Medical Center. He has received multiple honors for his research, including the Cotran Early Career Investigator Award from the American Society of Investigative Pathology, and the Jefferson-Pilot Fellowship in Academic Medicine from the University of North Carolina School of Medicine. He is active on the editorial boards of the American Journal of Pathology, Cardiovascular Pathology, Journal of Molecular and Cellular Cardiology, American Journal of Physiology-Endocrine and Metabolism and co-chairs an American Heart Association Study Section. Dr. Willis has published more than 210 manuscripts in clinical, translational, and the basic sciences and edited multiple medical textbooks, including Molecular and Translational Vascular Medicine (2012); Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies, and Imaging Techniques (2012), and the Cellular and Molecular Pathobiology of Cardiovascular disease (2013).

Affiliations and Expertise

University of North Carolina, Chapel Hill, NC, USA

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