Endocrine Disrupters, Volume 94

1st Edition

Serial Editors: Gerald Litwack
Hardcover ISBN: 9780128000953
eBook ISBN: 9780128005859
Imprint: Academic Press
Published Date: 15th January 2014
Page Count: 472
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Table of Contents

Chapter One. Endocrine-Disrupting Chemicals and Human Growth and Maturation: A Focus on Early Critical Windows of Exposure


1 Introduction

2 Challenges in Evidencing Endocrine Disruption

3 Endocrine-Disrupting Chemicals and Fetal Growth

4 EDCs and Sexual Differentiation

5 EDCs and Puberty

6 EDCs and Brain Development

7 EDC and Energy Balance

8 Epigenetic Perspective on the Developmental Effects of EDCs

9 Conclusion


Chapter Two. Agricultural Pesticides and Precocious Puberty


1 Introduction

2 Puberty

3 Precocious Puberty

4 The Effects of EDs on Puberty

5 Organochlorine Pesticides and Puberty

6 DDT and DDE

7 Methoxychlor

8 Endosulfans

9 Vinclozolin

10 Acetochlor

11 Conclusion


Chapter Three. Endocrine-Disrupting Chemicals: Elucidating Our Understanding of Their Role in Sex and Gender-Relevant End Points


1 Introduction

2 Endocrine Disruption May Underlie Negative Effects of Contaminants

3 Adverse Health Consequences of Lifelong EDC Exposure

4 Signficance of Investigating EDC Effects on Neurodevelopmental Processes

5 Hormones’ Effects to Organize Neural Systems and Behavioral Processes

6 Developmental EDC Exposure Alters Reproductive Development and Behavior

7 Exposure to EDCs in Adulthood Also Effects Reproductive Parameters

8 EDCs in Adulthood Influence Sexually Dimorphic Brain Morphology

9 Do EDCs Influence Sex Differences in Nonreproductive Behaviors?

10 Effects of EDCs on Sexually Dimorphic, Nonreproductive Behaviors

11 Potential Mechanisms by which EDCs May Produce Their Effects

12 Several Factors May Bear upon Estrogenicity of Compounds

13 Effects of EDCs on Uterotropic Activity

14 Importance


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones.  A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on endocrine disrupters.

Key Features

  • Expertise of the contributors
  • Coverage of a vast array of subjects
  • In depth current information at the molecular to the clinical levels
  • Three-dimensional structures in color
  • Elaborate signaling pathways


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.


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Academic Press
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About the Serial Editors

Gerald Litwack Serial Editor

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton,

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA