Encyclopedia of Cell Biology

Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and Biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University, and Professor and Chair of the Department of Biological Chemistry, University of California Irvine. He presently is Professor of Pharmacology at the University of California, San Diego. He served as president of FASEB, was the founding president of the Protein Society and was the treasurer of the ASBMB. He was the founding editor of Molecular and Cellular Proteomics. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signaling. He has also studied the role of proteolytic processing and N-terminal modification in protein stability and turnover.

Department of Chemistry and Pharmaceutical Chemistry; and Mass Spectrometry Facility, University of California, San Francisco, Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, Irvine, CA, USA

Philip D. Stahl is Professor Emeritus at Washington University School of Medicine in St. Louis. He was educated at West Virginia University and Vanderbilt University. He served as Head of the Department of Cell Biology and Physiology and Director of the Division of Biology and Biomedical Sciences at Washington University. He has been the recipient of many awards including a MERIT award from the NIH and the WICB Senior Recognition award given by the American Society for Cell Biology in recognition of his work supporting the advancement of women in science. Among Stahl Lab contributions are the discovery of the lysosomal enzyme clearance pathway now implemented in the treatment of lysosomal storage disease, discovery of the innate immune receptor, the mannose receptor, discovery of the exosome secretion pathway, and the role of Rab5 and Arf6 in endocytosis. Currently his research focuses on endocytosis, signal transduction, and exosome biogenesis and secretion.

Mallinckrodt Jr. Professor Emeritus, Washington University, St. Louis, MO, USA

Gerald W. Hart recently took a position as Georgia Research Alliance William Henry Terry, Sr. Eminent Scholar in Drug Discovery, and Professor of Biochemistry and Molecular Biology, University of Georgia. Prior to that he was at Johns Hopkins Medical School. Hart is the President of ASBMB and the recipient of a number of awards. He is Associate Editor of J. Biological Chemistry and of Molecular and Cellular Proteomics. He founded the journal Glycobiology. He performed early studies on cell surface heparan sulfates and on the roles of proteoglycans and sulfotransferases in corneal transparency. Hart’s laboratory discovered O-GlcNAcylation, co-led elucidation of GPI anchor biosynthesis with Paul Englund’s group, and documented the importance of protein structure for N-glycosylation. Hart later discovered the extensive crosstalk between O-GlcNAc and phosphorylation underlying the etiology of diabetes, neurodegenerative disease, cardiovascular disease and cancer.

Georgia Research Alliance William Henry Terry, Sr. Eminent Scholar in Drug Discovery; Professor of Biochemistry and Molecular Biology, University of Georgia, GA, USA