Encyclopedia of Cancer

Encyclopedia of Cancer

3rd Edition - October 12, 2018

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  • Editors-in-Chief: Paolo Boffetta, Pierre Hainaut
  • eBook ISBN: 9780128124857
  • Hardcover ISBN: 9780128124840

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Encyclopedia of Cancer, Third Edition, Three Volume Set provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented.

Key Features

  • Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics
  • Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health


Oncologists; cancer researchers; oncology fellows in training; students and researchers in biology and epidemiology. Medical doctors other than oncologists and other cancer-related medical professionals will also benefit

Table of Contents

    1. Mechanisms (edited by Gerd Pfeifer)
    2. Ataxia Telangiectasia Syndrome

      Hereditary Risk of Breast and Ovarian Cancer: BRCA1 and BRCA2

      Li–Fraumeni Syndrome

      Carcinogenesis: Role of Reactive Oxygen and Nitrogen Species

      Carcinogen-DNA adducts

      Polyomaviruses in Human Cancer

      Single Cell Sequencing and Tumor Heterogeneity

      Driver Versus Passenger Mutations in Tumors

      Mutational signatures and the aetiology of human cancers

      Copy Number Variations in Tumors

      Lynch Syndrome

      WNT Signaling in Intestinal Cancer

      Xeroderma Pigmentosum

      Bloom's Syndrome

      Mutations in DNA Methyltransferases and Demethylases

      Mutations in Chromatin Remodeling Factors

      Mutations in Histone Lysine Methyltransferases and Demethylases

      Cataloguing DNA Methylation Changes in Tumors

      Mechanisms of DNA Methylation Changes in Cancer

      Defective 5-Methylcytosine Oxidation in Tumorigenesis

      Biological Implications of DNA Methylation Changes in Cancer

      Altered Histone Modifications in Cancer

      Environmental Exposures and Epigenetic Perturbations

      Enhancer Malfunction in Cancer

      Epigenetic Therapy

      Aberrations in the TCA Cycle

      Molecular Mechanisms of Inflammation in Cancer

      Animal Models in Cancer Research - Mechanisms

      Rearrangements and Chromosome Translocations in Cancer

      Genome Wide Association Studies (GWAS)

      Oncogenesis by Unprogrammed Gene Activation: A Critical Evaluation of Cancer Testis Genes

      Hormones and Cancer


      Microbiota and Colon Cancer: Orchestrating Neoplasia Through

      DNA Damage and Immune Dysregulation

      Cancer Metabolomics

    3. Hallmarks of Cancer (edited by Marco Pierotti)

    Cell Responses to DNA Damage

    MAP Kinases

    Biphasic Role of TGF-β in Cancer Progression: From Tumor Suppressor to Tumor Promotor


    Microenvironment Hallmarks


    Tumors and Blood Vessel Interactions: a Changing Hallmark of Cancer

    Warburg Effect

    Glucose/Glucose Metabolism

    Lactate/Lactate Transport

    Glutamine Metabolism

    Lipid Metabolism

    Pyruvate Kinase

    Mevalonate Pathway


    Yamanaka factors and iPS


    Tumor-Associated Macrophages

    Genetic Instability

    DNA Damage Repair

    Mismatch Repair: Biochemistry and Genetics

    Senescence and Cellular Immortality


    Autophagy in Cancer


    Epithelial to Mesenchyme Transition

    Metastatic Signatures - The Tell-Tale Signs of Metastasis

    Cancer Heterogeneity and Evolutionary Dynamics

    Tunneling Nanotubes (TNTs)

    Cancer Cell Death

    Cancer System Biology

      1. Causes of Cancer (edited by Graham A. Colditz)

      Hepatitis C Virus (HCV)

      HIV (Human Immunodeficiency Virus)




      Dietary Factors and Cancer


      Physical Activity (lack of)



      Helicobacter Pylori

      Opisthorchis, Clonorchis and cholangiocarcinoma


      Chemical Carcinogens

      Cancers as Ecosystems: From Cells to Population

      Sleep Disturbance/Misalignment

      Environmental Exposures


    1. Prevention and Control (edited by Carlo La Vecchia)
    2. Cancer Risk Reduction (Diet/Smoking Cessation/Lifestyle Changes)

      Nutritional Supplements and Diet as Chemoprevention Agents

      Chemoprevention Trials

      Molecular Epidemiology and Cancer Risk

      Cancer Survival and Survivorship

      Tobacco Control

      Nutrition, Obesity, and Metabolism

      Environmental and Occupational Exposures

      Cancer Disparities

      Financial Burden of Cancer Care

      Identification and Management of Hereditary Cancer Syndromes: a Public Health Priority



      Diet and Diet Supplements




      Cervical Cancer; Screening

      Breast Cancer; Screening

      Cancer in East Asia

      Cancer in Sub-Saharan Africa

      Cancer in South Asia

      Cancer in Middle East

      Cancer in Latin America

      Cancer in Populations in Transition

      Cancer in Migrants


    3. Diagnosis and Therapy (edited by Marco Pierotti and Thomas Tursz)
    4. Cancer Vaccines: Gene Therapy and Dendritic Cell-Based Vaccines

      Interferons: Cellular and Molecular Biology of Their Actions

      P-Glycoprotein-Mediated Multidrug Resistance

      Hormone Resistance in Prostate Cancer

      Estrogens and Antiestrogens

      Immune Deficiency: Opportunistic Tumors

      Targeting the Epigenome

      End-of-Life Support

      Symptom Control

      Childhood Cancers: Global Approaches and New Perspectives

      Oral Cancer

      New Rationales and Designs for Clinical Trials in the Era of Precision Medicine

      Thyroid Cancer

      Precision Medicine

      Acute Lymphocytic Leukemia; Diagnosis and Treatment

      Acute Myelogenous Leukemia (in Adults and in Children); Diagnosis and Treatment

      Myelodysplastic Syndrome; Diagnosis and Treatment

      Esophageal Cancer; Diagnosis and Treatment

      Gastric Cancer; Diagnosis and Treatment

      Cancers of the Colorectum and Appendix; Diagnosis and Treatment

      Cancers of the Pancreas; Diagnosis and Treatment

      Cholangiocarcinoma; Diagnosis and Treatment

      Cancer of the Uterine Cervix; Diagnosis and Treatment

      Ovarian Cancer; Diagnosis and Treatment

      Non-Small Cell Cancers of the Lung; Diagnosis and Therapy

      Small Cell Cancer of the Lung; Diagnosis and Treatment

      Renal Cancer; Diagnosis and Treatment

      Pituitary Tumors; Diagnosis and Treatment

      Tumors of the Adrenal Glands; Diagnosis and Treatment

      Bladder Cancer; Diagnosis and Treatment

      Cancers of the Oral Cavity; Diagnosis and Treatment

      Cancers of the Larynx; Diagnosis and Treatment

      Squamous Cell and Basal Cell Carcinoma; Diagnosis and Treatment

      Malignant Melanomas: Diagnosis and Treatment

      Tumors of the Eye and of the Orbita

      Neuroblastoma; Diagnosis and Treatment

      Germ Cell Tumors; Diagnosis and Treatment

      Breast Cancer; Diagnosis and Treatment

      Breast Cancer: Biology and Therapeutic Consequences

      Bone and Soft Tissues Sarcomas; Diagnosis and Treatment

      Bone and Soft Tissues Sarcomas; Biology

      EBV-Related Malignancies; Diagnosis and Treatment

      Hodgkin's Disease; Diagnosis and Treatment

      Non-Hodgkin's Lymphoma; Diagnosis and Treatment

      Naso-Pharyngeal Carcinoma

      Advances in Cancer Imaging

      Advances in Radiation Therapies

      Glioblastoma: Biology, Diagnosis and Treatment

      Immunology of Human Tumors

      Acute Myeloblastic Leukemia

      Prostate Cancer: Diagnosis and Treatment


      Non-Small Cell Cancers of the Lung; Biology and Therapeutic Consequences

    5. Pathology and Genetics of Specific Cancers (edited by Fred Bosman)

    Glioblastoma: Pathology and Genetics


    Esophageal Cancer; Pathology and Genetics

    Gastric Cancer; Pathology and Genetics

    Colorectal Cancer; Pathology and Genetics

    Cancers of the Pancreas: Pathology and Genetics

    Cancer of the Uterine Cervix; Pathology and Genetics

    Ovarian Cancer; Pathology and Genetics

    Non-Small Cell Cancers of the Lung; Pathology and Genetics

    Small Cell Cancer of the Lung; Pathology and Genetics

    Pituitary Tumors; Pathology and Genetics

    Tumors of the Adrenal Glands; Pathology and Genetics

    Parathyroid Cancer; Pathology and Genetics

    Cancers of the Oral Cavity; Pathology and Genetics

    Cancers of the Jaws; Pathology and Genetics

    Cancers of the Larynx; Pathology and Genetics

    Melanoma; Pathology and Genetics

    Malignant Skin Adnexal Tumors; Pathology and Genetics

    Cancers of the Eye and Orbita; Pathology and Genetics

    Anal Cancer; Pathology and Genetics

    Neuroblastoma; Pathology and Genetics

    Wilms Tumor; Pathology and Genetics

    Integrative Molecular Pathology

    Chronic Lymphocytic Leukemia; Pathology and Genetics

    Chronic Myelogenous Leukemia; Pathology and Genetics

    Lymphoma, Hodgkin's; Pathology and Genetics

    Lymphoma, non-Hodgkin's; Pathology and Genetics

    Multiple Myeloma; Pathology and Genetics

    Cancer of the Liver

    Endometrial Cancer; Pathology and Genetics

    Breast Cancer; Pathology and Genetics

    Renal Cell Cancer; Pathology and Genetics

    Prostate Cancer; Pathology and Genetics

    Cancer of Bone and Joints

    Germ Cell Tumors: Pathology and Genetics

Product details

  • No. of pages: 1841
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: October 12, 2018
  • Imprint: Academic Press
  • eBook ISBN: 9780128124857
  • Hardcover ISBN: 9780128124840

About the Editors in Chief

Paolo Boffetta

Dr. Boffetta moved to Mount Sinai School of Medicine in 2010. He is Associate Director for Population Sciences of The Tisch Cancer Institute and Chief of the Division of Cancer Prevention and Control of the Department of Oncological Sciences. He is also the Bluhdorn Professor of International Community Medicine. Dr. Boffetta is Adjunct Professor at the Harvard School of Public Health (Boston, MA), Vanderbilt University (Nashville, TN), and the Catholic University of Rome (Italy). He is also Affiliate Member of the R. Samuel McLaughlin Centre for Population Health Risk Assessment, University of Ottawa (Ottawa, Canada), and Senior Fellow of the Hellenic Health Foundation (Athens, Greece). H-index 99; 1134 documents; publication range 1987 – present; over 150 co-authors; 42,863 citations in 29,080 documents

Affiliations and Expertise

Icahn School of Medicine, Mount Sinai, NY, USA

Pierre Hainaut

Pierre Hainaut (born 1958, Belgium) is PhD in Biology, University of Liège, Belgium, 1987. After postdocs in France and in the UK (1988-1994), he joined the International Agency for Research on Cancer (IARC, World Health Organization) in 1994, where he held the post of head of Molecular Carcinogenesis from 1999 to 2011. In 2012, he joined the International Prevention Research Institute as Research Director. Since 2014, has been appointed as Professor of Cancer Biology and Chair of Excellence in Translational Research at Université Grenoble Alpes, France. Since October 2014, he is Director of the Institute of Advanced Biosciences (formerly Institut Albert Bonniot), a multi-thematic research center supported dedicated to Epigenetics, Chronic Diseases and Cancer (17 research teams). His research focuses on TP53 mutations and on biomarkers of transition from chronic diseases to cancer. From 1994 to 2011, he has led the development of the international IARC database of TP53 mutations, a source of information on the causes and consequences of mutations affecting the p53 suppressor protein in cancer. His current research focuses on gain-of-function effects in lung cancer and on biomarkers for early detection of liver and lung cancers, in particular in low-resource countries. Pierre Hainaut is author of over 400 publications and 50 book chapters (h index: 72, Google Scholar). He has co-edited two books on p53 (“25 Years of p53 Research” 2005, 2007, “p53 in the Clinics”, Springer) and a textbook of Molecular Epidemiology (“Molecular Epidemiology: Principle and Practice”, IARC Press, 2011).

Affiliations and Expertise

Institute for Advanced Biosciences, University Grenoble-Alpes, Grenoble, France

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  • Annonymous Tue Jan 22 2019

    Very helpful.

    This book is a fantastic and helpful tool for basic scientists and clinicians.