Emerging Therapies in Thoracic Malignancies, An Issue of Surgical Oncology Clinics of North America

1st Edition, Volume 29-4 - September 7, 2020
Editors: Usman Ahmad, Sudish Murthy
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 5 9 4 1 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 5 9 4 0 - 3

This issue of Surgical Oncology Clinics of North America, guest edited by Drs. Usman Ahmad and Sudish Murthy, is devoted to Emerging Therapies in Thoracic Malignancies. Drs. Ahmad… Read more

Emerging Therapies in Thoracic Malignancies, An Issue of Surgical Oncology Clinics of North America

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This issue of Surgical Oncology Clinics of North America, guest edited by Drs. Usman Ahmad and Sudish Murthy, is devoted to Emerging Therapies in Thoracic Malignancies. Drs. Ahmad and Murthy has assembled expert authors to review the following topics: Mediastinal Germ Cell Tumors: Updates in Diagnosis and Management; Multidisciplinary Evaluation and Management of Early Stage Esophageal Cancer; Evaluation of Risk for Thoracic Surgery; Mesothelioma: Updates in Staging and Management; Chest Wall Sarcoma: When and Who to Resect and How to Reconstruct; Management of Locally Advanced Esophageal Cancer; Locally Advanced Lung Cancer and Salvage Resections; Siewert III Adenocarcinoma: Still Searching for the Right Treatment Combination; Current Indications for Pulmonary Metastasectomy; Lung Cancer Screening; Thymic Malignancies: Updates in Treatment and Staging; Intra-operative Detection and Assessment of Lung Nodules; Targeted Therapies, Immunotherapy and T-Cell Therapy in Lung Cancer; and more!

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Evaluation of Risk for Thoracic Surgery
Key points
Introduction
Estimation of cardiovascular risk
Pulmonary function
Exercise tests
Implications of risk assessment
Special considerations
Shared decision making
Summary
Lung Cancer Screening
Key points
Introduction
Evidence that supports lung cancer screening
Potential harms
Implementation of screening programs
Future directions
Intraoperative Detection and Assessment of Lung Nodules
Key points
Introduction
Clinical challenges
Nonsurgical biopsy adjuncts
Preoperative nodule localization
Intraoperative imaging-guided nodule localization
Intraoperative margin assessment
Summary
Surgery for Locally Advanced and Oligometastatic Non–Small Cell Lung Cancer
Key points
Introduction
Preoperative evaluation
Salvage lung resection
Stage IV oligometastatic disease
Lung resection and immunotherapy
Summary
Emerging Therapies in Thoracic Malignancies—Immunotherapy, Targeted Therapy, and T-Cell Therapy in Non–Small Cell Lung Cancer
Key points
Introduction
Immunotherapy in non–small cell lung cancer
Tyrosine kinase inhibitors and targeted therapy
Adoptive T-cell therapies, including tumor-infiltrating lymphocytes therapy, chimeric antigen receptor T cells, and T-cell receptor
Summary
Mediastinal Germ Cell Tumors: Updates in Diagnosis and Management
Key points
Introduction
Diagnosis
Treatment
Summary
Thymic Malignancy—Updates in Staging and Management
Key points
Introduction
General approach and principles
Updates in staging
Induction chemotherapy
Induction chemoradiation
Induction radiation
Updates in surgical resection
Postoperative radiation therapy
Special considerations
Management of recurrent disease
Targeted therapies and immunotherapies
Updates in Staging and Management of Malignant Pleural Mesothelioma
Key points
Introduction
Staging in malignant pleural mesothelioma
Surgical resection for malignant pleural mesothelioma
Data comparing extrapleural pneumonectomy with pleurectomy/decortication
Immunotherapy in malignant pleural mesothelioma
Summary
Multidisciplinary Evaluation and Management of Early Stage Esophageal Cancer
Key points
Introduction
Clinical presentation
Staging of early esophageal cancer
Endoscopic ultrasound examination
PET/Computed tomography scans
Endoscopic treatment options
Indications for endoscopic submucosal dissection
Postendoscopic resection pathologic results
Surgery for early esophageal cancer
Chemotherapy and radiation in early esophageal cancer
Surveillance
Summary
Management of Locally Advanced Esophageal Cancer
Key points
Background
Definition of locally advanced
Surgical approaches for esophagectomy
Neoadjuvant chemotherapy
Trimodality therapy
Neoadjuvant chemotherapy versus neoadjuvant chemoradiation
Bimodality therapy (definitive chemoradiation)
Selective surgery strategy
Salvage esophagectomy
Surveillance after definitive treatment
Targeted therapy
Immune checkpoint inhibitors
Palliation of locally advanced esophageal cancer
Summary
Siewert III Adenocarcinoma: Still Searching for the Right Treatment Combination
Key points
Introduction
Current definitions: American Joint Commission on Cancer 7 versus American Joint Commission on Cancer 8
Landmark clinical trials: neoadjuvant therapy? If so, which one?
Surgical approach: how high should we go?
Summary
Future directions
Surgical Management of Chest Wall Sarcoma
Key points
Introduction
Adjuvant radiation therapy
Adjuvant systemic therapy
Current Indications for Pulmonary Metastasectomy
Key points
Introduction
Patient Assessment
Radiologic studies
Eligibility for Pulmonary Metastasectomy
Prognostic Factors
Operative Techniques for Pulmonary Metastasectomy
Tumor-Type Specific Outcomes
Nonoperative techniques for pulmonary metastasectomy
Future direction