Emerging Targets and Therapeutics in the Treatment of Psychostimulant Abuse, Volume 69

1st Edition

Editors: Linda P. Dwoskin
Hardcover ISBN: 9780124201187
eBook ISBN: 9780124201774
Imprint: Academic Press
Published Date: 19th February 2014
Page Count: 656
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Table of Contents

Preface
Contributors
Chapter One: Glial Modulators as Potential Treatments of Psychostimulant Abuse
Abstract

1 Introduction

2 Molecular Biology and Physiology of the Glia

3 In Vivo Evidence that Modulating Glia and Neuroinflammation Provide Pharmacotherapeutic Possibilities for Psychostimulant Abuse

4 Ongoing or Planned Clinical Studies Examining Glial Modulators in the Treatment of Psychostimulant Abuse

5 Conclusion

Conflict of Interest

Chapter Two: The Vesicular Monoamine Transporter-2
Abstract

1 Methamphetamine Addiction

2 Methamphetamine: Mechanism of Action

3 Identification and Classification of Vesicular Monoamine Transporters

4 VMAT2 Function

5 VMAT2 Binding Sites

6 Aberrant VMAT2 Expression and Function

7 Conclusion

Conflict of Interest

Acknowledgments

Chapter Three: Customizing Monoclonal Antibodies for the Treatment of Methamphetamine Abuse
Abstract

1 Introduction

2 METH Mechanisms of Action, Toxicity, and Current Therapies

3 Therapeutic Monoclonal Antibodies to Counteract METH Effects

4 Predicting Therapeutic Effectiveness

5 METH Metabolism and Pharmacokinetics: Choosing the Appropriate Animal Testing Model

6 The Role of Affinity, Binding Capacity, and In Vivo Modifications in mAb Function

7 Hapten Design for Improved Target Specificity and mAb Functionality

8 Relationship Between Hapten Structure and mAb Function: Application to Other Antibody Forms

9 Antibody Form and Duration of Action

10 Conclusion

Conflict of Interest

Acknowledgments

Chapter Four: Monoamine Transporter Inhibitors and Substrates as Treatments for Stimulant Abuse
Abstract

1 Introduction

2 Operant Behavior in Medication Development

3 Monoamine Transporters as Molecular Targets for Medication Development


Description

This new volume of Advances in Pharmacology presents the emerging targets and therapeutics in the treatment of psychostimulant abuse. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Key Features

  • Contributions from the best authors in the field
  • An essential resource for pharmacologists, immunologists, and biochemists

Readership

Pharmacologists, immunologists, and biochemists


Details

No. of pages:
656
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780124201774
Hardcover ISBN:
9780124201187

About the Editors

Linda P. Dwoskin Editor

Affiliations and Expertise

Pharmaceutical Education, College of Pharmacy, University of Kentucky, Lexington, KY, USA