1. Nanopharmaceutics in immunology: what's new in research?
Ranjita Shegokar and Eliana Souto
2. Skin delivery of antimicrobial peptides
Monika Schaefer-Korting and Jens Rolff
3. Skin penetration of nnaoparticles
Howard Mayback and Shohreh Nafisi
4. Regulatory and risk assessment perspective for Core-Multishell Nanocarriers: A novel excipient on its way towards marketing authorization
Sam D. More and Emanuel Fleige
5. Anti-inflammatory drugs: Pharmaceutical Nanotechnology approach
Slavomira Doktorovova and Andjelka Kovacevic
6. New strategies for the treatment of auto-immune diseases using nanotechnologies
Amelia M. Silva, Maria dos Anjos Pires and Dario J. L. Santos
7. Nanopharmaceutics Applications in Inhaler Systems
Mine Ozyazici, Aysu Yurdasiper and Mesut Arıcı
8. Immunomodulatory Effects of Curcumin in infectious and non-infectious diseases
9. Advances in Antibiotic Nanotherapy: Overcoming Antimicrobial Resistance
The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body. This book aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.
The contributors address a representative set of the broad spectrum of nanopharmaceutics presently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue-engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use.
- Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals currently under research for topical administration of drugs
- Focus on the characterization and quantification of the nanopharmaceutics to allow readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects
- Includes a thorough overview of the legal and regulatory aspects, including discussion of the ethical issues related to the R&D of nanopharmaceuticals
Academics, researchers and scientists, as well as post-graduates, developing their research in the area of the Topical Drug Delivery; Policy makers and pharmaceutical companies and learned societies, associations and research groups working in topical nanopharmaceuticals
- No. of pages:
- © Elsevier 2018
- 1st May 2018
- Hardcover ISBN:
Eliana B. Souto is Assistant Professor of Pharmaceutical Technology at the Faculty of Health Sciences in University Fernando Pessoa in Porto, Portugal. In her home University she coordinates the Biopharmaceutical Chemistry Unit of the Doctoral Programme in Biotechnology and Health, and the EuroPhD in Advanced Drug Delivery from Galenos Network. She also belongs to the Institute for Biotechnology and Bioengineering, Centre of Genetic and Biotechnology. Eliana B. Souto is graduated in Pharmaceutical Sciences from the Faculty of Pharmacy, University of Coimbra. She also obtained a post-graduated Master degree in Pharmaceutical Technology and Pharmacotechnique at the Faculty of Pharmacy, University of Porto, and awarded with the degree of PhD in Pharmaceutical Technology, Biopharmaceutics and Biotechnology at the Institute of Pharmacy, Free University of Berlin, Germany. Her research group is devoted to the design, development, and characterization of lipid nanocarriers for controlled delivery of drugs across biological barriers, namely skin, gastrointestinal tract, blood-retinal and blood-brain barriers. Eliana is member of the Editorial Board of several other peer-reviewed scientific journals, author and co-author more than 70 full-length published SCI articles, 15 book chapters, 150 abstracts and/or proceedings published in national and international meetings.
Assistant Professor of Pharmaceutical Technology, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal