Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices

Chapter 1. Therapeutic Applications of Polymeric Materials

• 1. Introduction
• 2. Polymers as Drug Delivery Systems
• 3. Polymers in Imaging and Diagnosis
• 4. Conclusion

Chapter 2. Multifunctional Micro- and Nanoparticles

• 1. Introduction
• 2. Micro- and Nanomaterials in the Synthesis of Multifunctional Carriers
• 3. Types of Functional Moieties
• 4. Functionalization of Micro- and Nanoparticles

Chapter 3. Nanomicelles in Diagnosis and Drug Delivery

• 1. Introduction
• 2. Nanomicelle Preparation
• 3. Application of Nanomicelle in Diagnostics and Imaging
• 4. Application of Nanomicelles in Drug Delivery
• 5. Conclusion

Chapter 4. Diagnosis and Drug Delivery to the Brain: Novel Strategies

• 1. Introduction
• 2. Barriers for Brain Drug Delivery
• 3. Physiology of the Blood–Brain Barrier
• 4. Invasive Drug Delivery Approaches
• 5. Noninvasive Drug Delivery Approaches
• 6. Nanotechnology Approaches
• 7. Active Blood–Brain Barrier Targeting Strategies
• 8. Novel Nanoplatforms and Delivery Vehicles for BBB Targeting
• 9. Development of Neurodiagnostic Nanoimaging Platforms
• 10. Conclusion

Chapter 5. Emerging Nanotechnology for Stem Cell Therapy

• 1. Introduction
• 2. Application of Nanoparticles in Isolation of Stem Cells
• 3. Application of Nanoparticles in Stem Cell Tracking
• 4. Role of Nanotechnology in Regulating Microenvironment of Stem Cells: Potential Roles in Tissue Engineering
• 5. Nanoparticles as Macromolecular Delivery Systems for Stem Cells
• 6. Future Prospects and Challenges Facing the Field

Chapter 6. Nanoparticulate Systems for Therapeutic and Diagnostic Applications

• 1. Introduction
• 2. Why Nanotechnology and Nanomedicine?
• 3. Types of Nanoparticles in Drug Delivery
• 4. Conclusion

Chapter 7. Peptide and Protein-Based Therapeutic Agents

• 1. Introduction
• 2. Challenges With Peptide and Protein Therapeutics
• 3. Chemical Modifications
• 4. Micro- and Nanotechnology for Biologics in Drug Delivery
• 5. Protein- and Peptide-Based Therapeutics
• 6. Conclusion

Chapter 8. Nanotechnology in Intracellular Trafficking, Imaging, and Delivery of Therapeutic Agents

• 1. Introduction
• 2. Mechanisms
• 3. Macropinocytosis
• 4. Conclusion

Chapter 9. Electrospun Nanofibers in Drug Delivery: Fabrication, Advances, and Biomedical Applications

• 1. Introduction
• 2. Stimuli-Responsive Nanofibers in Drug Delivery Applications
• 3. Applications of Electrospun Nanofibers
• 4. Conclusion

Chapter 10. Nanosystems for Diagnostic Imaging, Biodetectors, and Biosensors

• 1. Introduction
• 2. Nanosystems as Platforms for Advanced Diagnostic Imaging
• 3. Diagnostic Imaging With Nanosystems
• 4. Biological Sensors
• 5. Conclusions

Chapter 11. Micro- and Nanotechnology-Based Implantable Devices and Bionics

• 1. Introduction
• 2. Biocompatibility Issues of Implants
• 3. Microtechnology-Based Implantable Devices and Bionics
• 4. Nanotechnology-Based Implantable Devices and Bionics
• 5. Conclusions and Future Perspectives

Chapter 12. Solid Lipid Nanoparticles in Drug Delivery: Opportunities and Challenges

• 1. Introduction
• 2. Components of Solid Lipid Nanoparticles
• 3. Solid Lipid Nanoparticle Production Techniques
• 4. Drug-Loading Capacity of Solid Lipid Nanoparticles
• 5. Drug Incorporation Models of Solid Lipid Nanoparticles
• 6. Drug Release From Solid Lipid Nanoparticles
• 7. Applications of Solid Lipid Nanoparticles for Drug Delivery
• 8. Stability Concerns of Solid Lipid Nanoparticles
• 9. Toxicity Aspects of Solid Lipid Nanoparticles
• 10. Diagnostic Applications of Solid Lipid Nanoparticles
• 11. In Vivo Fate of Solid Lipid Nanoparticles
• 12. Conclusions

Chapter 13. Microneedles in Drug Delivery

• 1. Introduction
• 2. Skin Structure and Barrier to Transdermal Delivery
• 3. Microneedles
• 4. Selection of Microneedle Designs for Applications
• 5. Commercial Microneedle Devices

Chapter 14. Nanotechnology-Based Medical and Biomedical Imaging for Diagnostics

• 1. Introduction
• 2. Fluorescence-Based Imaging and Diagnostics
• 3. Nanocarriers in Biological Imaging
• 4. Photoacoustic and Ultrasound Imaging
• 5. Conclusions

Chapter 15. Drug and Gene Delivery Materials and Devices

• 1. Introduction
• 2. Advances in Delivery Systems
• 3. Gene Delivery
• 4. Gene Therapy Products
• 5. Conclusion and Future Direction