Emerging Nanomedicines for Diabetes Mellitus Theranostics
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Emerging Nanomedicines for Diabetes Mellitus Theranostics provides readers with information on the development of efficacious nanomedicines as potential theranostic agents for diabetes. The book discusses the application of various novel nanomaterials and nanocomposites for targeted delivery of insulin, glucose sensing, including nano-tattoos as glucose monitors, biosynthesized nanoparticles for diabetes treatment, and pre-clinical and clinical assays to evaluate the efficacy of nanomedicines for diabetes treatment. This is an important references source for materials scientists, pharmaceutical scientists and biomedical engineers who want to increase their understanding of how nanotechnology is being used to improve diabetes treatment. Diabetes has emerged as one of the most common diseases associated with lifestyle choices in the modern world, with significant mortality rates. Conventional treatment methods mainly involve insulin-based therapies. However, insulin therapy possesses several limitations such as weight gain and hypoglycemia. Thus, advanced research in nanomedicine is targeting the development of new and improved diagnostics and treatment methods for diabetes.
Key Features
- Explores the significance of nanomaterials and nanocomposites for the controlled delivery of insulin and effective diagnosis of diabetes
- Assesses the efficacy of novel nano-tattoos as an emerging glucose monitoring system and the potential of biosynthesized nanoparticles as pharmaceutical ingredients for diabetes treatment
- Describes various pre-clinical and clinical assays to evaluate the toxicity of nanomedicines, along with methods to mitigate the challenges associated with effective diabetes therapy via the use of nanorobots, nanoformulations and smartphone-based technologies
Readership
Materials Scientists and Engineers
Table of Contents
- Cover image
- Title page
- Table of Contents
- Copyright
- About the authors
- Preface
- Acknowledgments
- Chapter 1. The current state of diabetes treatment
- Abstract
- Introduction
- Types of diabetes
- Pathophysiology of diabetes
- Conventional treatment for diabetes mellitus
- Latest insulin therapy routes and drugs for diabetes management
- Conclusion
- References
- Further reading
- Chapter 2. Nanoparticles and nanocomposites for controlled delivery of insulin
- Abstract
- Introduction
- Classification of nanoparticles
- Nanocomposites
- Nanoparticles and nanomaterials for controlled delivery of insulin
- Nanocomposites in controlled insulin delivery
- Route of administration for nanomaterial-based insulin delivery
- Mechanism of nanomaterial-based insulin delivery
- Advantages and limitations of nanomaterials and nanoparticles
- Conclusion
- References
- Further reading
- Chapter 3. Nanomaterials as glucose sensors for diabetes monitoring
- Abstract
- Introduction
- Developments in glucose sensors
- Types of glucose sensors
- Nanomaterials in glucose sensing
- Nanocomposites as glucose sensors
- Biosynthesized nanoparticles as glucose sensors
- Current trends in nanoglucose sensors
- Conclusion
- References
- Further reading
- Chapter 4. Nano-tattoos—a novel approach for glucose monitoring and diabetes management
- Abstract
- Introduction
- Fabrication of nano-tattoos
- Amyloid aggregation
- Recent updates in nano-tattoos
- Mechanism of nano-tattoos as glucose sensors
- Advantages of nano-tattoos
- Challenges in using nano-tattoos as glucose sensors
- Future perspective
- Conclusion
- References
- Chapter 5. Metal and metal oxide nanoparticles: synthesis, properties, and applications as nanomedicines for diabetes treatment
- Abstract
- Introduction
- Classification of metal and metal oxide nanoparticles
- Metal nanoparticles as nanomedicines for diabetes treatment
- Metal oxide nanoparticles as nanomedicines for diabetes treatment
- Phytosynthesized metal and metal oxide nanoparticles as nanomedicines for diabetes treatment
- Mechanism of metal and metal oxide nanoparticles in diabetes treatment
- Future perspective
- Conclusion
- References
- Chapter 6. Biosynthesized nanoparticles for diabetes treatment
- Abstract
- Introduction
- Synthesis of nanoparticles via microbes
- Synthesis of nanoparticles via plant extract and natural products
- Microbially synthesized nanoparticles as glucose sensors
- Phytosynthesized nanoparticles as glucose sensors
- Biosynthesized nanoparticles for controlled insulin therapy
- Biosynthesized nanoparticles with antidiabetic effect
- Future perspectives
- Conclusion
- References
- Chapter 7. Cytotoxicity of nanoparticles toward diabetic cell models
- Abstract
- Introduction
- Diabetic cell models
- Cytotoxicity of nanoparticles toward diabetic cell models
- Cytotoxicity of nanoformulations toward diabetic cell models
- Cytotoxicity mechanism of nanoparticles
- Future perspective
- Conclusion
- References
- Chapter 8. In vivo studies of nanoparticles in diabetic models
- Abstract
- Introduction
- Diabetic animal models
- Toxicity of nanoparticles in animal models
- Toxicity of nanoformulations toward diabetic animal models
- Toxicity mechanism of nanoparticles toward diabetic animal models
- Future perspectives
- Conclusion
- References
- Chapter 9. Preclinical and clinical evaluation of nanodrugs for diabetes treatment
- Abstract
- Introduction
- Biochemical and cellular assays for antidiabetic analysis
- Evaluation of antidiabetic nanoparticles
- FDA approved polymeric antidiabetic nanomedicines
- Limitations to the use of nanoparticles in disease treatments
- Recommendations and future perspective
- Conclusion
- References
- Chapter 10. Future of nanoparticles, nanomaterials, and nanomedicines in diabetes treatment
- Abstract
- Introduction
- Limitations of nanomedicines
- Future of nanobased technologies in diabetes diagnosis
- Future of nanomedicines and nanodevices in diabetes therapy
- Research advancements and recommendations
- Conclusion
- References
- Index
Product details
- No. of pages: 280
- Language: English
- Copyright: © Elsevier 2022
- Published: April 9, 2022
- Imprint: Elsevier
- Paperback ISBN: 9780323853965
- eBook ISBN: 9780323853972
About the Authors
Michael Danquah
Dr. Danquah is a full Professor and the Director of Chemical Engineering Program at the University of Tennessee, Chattanooga, United States. He is a Chartered Engineer (CEng), Chartered Professional Engineer (CPEng), Chartered Scientist (CSci) and a Fellow of the Institution of Chemical Engineers (IChemE). Dr. Danquah’s research focuses on the utilization of bioprocess and biomolecular engineering principles to develop emerging biopharmaceuticals, biosensing and molecular separation systems; environmental bioremediation systems; and biofuels and bio-products. Dr. Danquah’s research findings are well published and cited with over 230 peer-reviewed journal articles, book chapters, conference publications and technical reports. His research has also resulted in intellectual properties and patent applications, large-scale manufacturing plants, and commercialized products and formulations.
Affiliations and Expertise
Professor and the Director of Chemical Engineering Program at the University of Tennessee, Chattanooga, United States
Jaison Jeevanandam
Dr. Jaison Jeevanandam is currently working as a senior researcher in Centro De Quimica Da Madeira (CQM – Center for Chemistry), University of Madeira, Portugal. He obtained his Ph.D. in the Department of Chemical Engineering, Faculty of Engineering and Science from Curtin University, Malaysia. He has experience in nanoparticle synthesis, especially in the green synthesis using plant extracts, characterization, cytotoxic analysis of nanoparticles, and in vitro analysis in diabetic models. His current research focuses on the application of nanobiotechnology in the development of nanoformulations for drug delivery systems. He has won several awards, including ‘Best teacher award 2019’ from Academy of competitive exam and research training (ACERT, Chennai), India; Gold medal in 3rd World Invention Innovation Contest (WiC) in 2017 from Korea Invention News (South Korea); Special honor of invention award, 3rd World Invention Innovation Contest (WiC) in 2017 from Toronto International Society of Innovation & Advanced Skills (TISIAS) (Canada). Dr. Jaison has authored +50 articles. Further, Dr. Jaison serves as a journal editor for Bio-integration (China) and International Archives of Biomedical and Engineering Sciences (India), as well as an invited editor for special issue in applied sciences (MDPI), Frontiers in Bioengineering and Biotechnology (Research topic coordinator) and Frontiers in molecular biosciences; and reviewer for 10+ journals.
Affiliations and Expertise
Senior Researcher, CQM - Centro De Quimica Da Madeira, MMRG, Universidade Da Madeira, Funchal, Madeira, Portugal
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