Emerging Nanomedicines for Diabetes Mellitus Theranostics

1st Edition - April 9, 2022
Authors: Michael K Danquah, Jaison Jeevanandam
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 9 6 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 9 7 - 2

Emerging Nanomedicines for Diabetes Mellitus Theranostics provides readers with information on the development of efficacious nanomedicines as potential theranostic agents fo… Read more

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code is needed.

Institutional subscription on ScienceDirect

Request a sales quote

Emerging Nanomedicines for Diabetes Mellitus Theranostics provides readers with information on the development of efficacious nanomedicines as potential theranostic agents for diabetes. The book discusses the application of various novel nanomaterials and nanocomposites for targeted delivery of insulin, glucose sensing, including nano-tattoos as glucose monitors, biosynthesized nanoparticles for diabetes treatment, and pre-clinical and clinical assays to evaluate the efficacy of nanomedicines for diabetes treatment. This is an important references source for materials scientists, pharmaceutical scientists and biomedical engineers who want to increase their understanding of how nanotechnology is being used to improve diabetes treatment.

Diabetes has emerged as one of the most common diseases associated with lifestyle choices in the modern world, with significant mortality rates. Conventional treatment methods mainly involve insulin-based therapies. However, insulin therapy possesses several limitations such as weight gain and hypoglycemia. Thus, advanced research in nanomedicine is targeting the development of new and improved diagnostics and treatment methods for diabetes.

Cover image
Title page
Table of Contents
Copyright
About the authors
Preface
Acknowledgments
Chapter 1. The current state of diabetes treatment
Abstract
Introduction
Types of diabetes
Pathophysiology of diabetes
Conventional treatment for diabetes mellitus
Latest insulin therapy routes and drugs for diabetes management
Conclusion
References
Further reading
Chapter 2. Nanoparticles and nanocomposites for controlled delivery of insulin
Abstract
Introduction
Classification of nanoparticles
Nanocomposites
Nanoparticles and nanomaterials for controlled delivery of insulin
Nanocomposites in controlled insulin delivery
Route of administration for nanomaterial-based insulin delivery
Mechanism of nanomaterial-based insulin delivery
Advantages and limitations of nanomaterials and nanoparticles
Conclusion
References
Further reading
Chapter 3. Nanomaterials as glucose sensors for diabetes monitoring
Abstract
Introduction
Developments in glucose sensors
Types of glucose sensors
Nanomaterials in glucose sensing
Nanocomposites as glucose sensors
Biosynthesized nanoparticles as glucose sensors
Current trends in nanoglucose sensors
Conclusion
References
Further reading
Chapter 4. Nano-tattoos—a novel approach for glucose monitoring and diabetes management
Abstract
Introduction
Fabrication of nano-tattoos
Amyloid aggregation
Recent updates in nano-tattoos
Mechanism of nano-tattoos as glucose sensors
Advantages of nano-tattoos
Challenges in using nano-tattoos as glucose sensors
Future perspective
Conclusion
References
Chapter 5. Metal and metal oxide nanoparticles: synthesis, properties, and applications as nanomedicines for diabetes treatment
Abstract
Introduction
Classification of metal and metal oxide nanoparticles
Metal nanoparticles as nanomedicines for diabetes treatment
Metal oxide nanoparticles as nanomedicines for diabetes treatment
Phytosynthesized metal and metal oxide nanoparticles as nanomedicines for diabetes treatment
Mechanism of metal and metal oxide nanoparticles in diabetes treatment
Future perspective
Conclusion
References
Chapter 6. Biosynthesized nanoparticles for diabetes treatment
Abstract
Introduction
Synthesis of nanoparticles via microbes
Synthesis of nanoparticles via plant extract and natural products
Microbially synthesized nanoparticles as glucose sensors
Phytosynthesized nanoparticles as glucose sensors
Biosynthesized nanoparticles for controlled insulin therapy
Biosynthesized nanoparticles with antidiabetic effect
Future perspectives
Conclusion
References
Chapter 7. Cytotoxicity of nanoparticles toward diabetic cell models
Abstract
Introduction
Diabetic cell models
Cytotoxicity of nanoparticles toward diabetic cell models
Cytotoxicity of nanoformulations toward diabetic cell models
Cytotoxicity mechanism of nanoparticles
Future perspective
Conclusion
References
Chapter 8. In vivo studies of nanoparticles in diabetic models
Abstract
Introduction
Diabetic animal models
Toxicity of nanoparticles in animal models
Toxicity of nanoformulations toward diabetic animal models
Toxicity mechanism of nanoparticles toward diabetic animal models
Future perspectives
Conclusion
References
Chapter 9. Preclinical and clinical evaluation of nanodrugs for diabetes treatment
Abstract
Introduction
Biochemical and cellular assays for antidiabetic analysis
Evaluation of antidiabetic nanoparticles
FDA approved polymeric antidiabetic nanomedicines
Limitations to the use of nanoparticles in disease treatments
Recommendations and future perspective
Conclusion
References
Chapter 10. Future of nanoparticles, nanomaterials, and nanomedicines in diabetes treatment
Abstract
Introduction
Limitations of nanomedicines
Future of nanobased technologies in diabetes diagnosis
Future of nanomedicines and nanodevices in diabetes therapy
Research advancements and recommendations
Conclusion
References
Index

Michael K Danquah

Dr. Danquah is a full Professor and the Director of Chemical Engineering Program at the University of Tennessee, Chattanooga, United States. He is a Chartered Engineer (CEng), Chartered Professional Engineer (CPEng), Chartered Scientist (CSci) and a Fellow of the Institution of Chemical Engineers (IChemE). Dr. Danquah’s research focuses on the utilization of bioprocess and biomolecular engineering principles to develop emerging biopharmaceuticals, biosensing and molecular separation systems; environmental bioremediation systems; and biofuels and bio-products. Dr. Danquah’s research findings are well published and cited with over 230 peer-reviewed journal articles, book chapters, conference publications and technical reports. His research has also resulted in intellectual properties and patent applications, large-scale manufacturing plants, and commercialized products and formulations.

Affiliations and expertise

Chemical Engineering Department, University of Tennessee, Chattanooga, TN, USA

Jaison Jeevanandam

Dr. Jaison Jeevanandam is currently working as a senior researcher in Centro De Quimica Da Madeira (CQM – Center for Chemistry), University of Madeira, Portugal. He obtained his Ph.D. in the Department of Chemical Engineering, Faculty of Engineering and Science from Curtin University, Malaysia. He has experience in nanoparticle synthesis, especially in the green synthesis using plant extracts, characterization, cytotoxic analysis of nanoparticles, and in vitro analysis in diabetic models. His current research focuses on the application of nanobiotechnology in the development of nanoformulations for drug delivery systems. He has won several awards, including ‘Best teacher award 2019’ from Academy of competitive exam and research training (ACERT, Chennai), India; Gold medal in 3rd World Invention Innovation Contest (WiC) in 2017 from Korea Invention News (South Korea); Special honor of invention award, 3rd World Invention Innovation Contest (WiC) in 2017 from Toronto International Society of Innovation & Advanced Skills (TISIAS) (Canada). Dr. Jaison has authored +50 articles. Further, Dr. Jaison serves as a journal editor for Bio-integration (China) and International Archives of Biomedical and Engineering Sciences (India), as well as an invited editor for special issue in applied sciences (MDPI), Frontiers in Bioengineering and Biotechnology (Research topic coordinator) and Frontiers in molecular biosciences; and reviewer for 10+ journals.

Affiliations and expertise

Senior Researcher, CQM - Centro De Quimica Da Madeira, MMRG, Universidade Da Madeira, Funchal, Madeira, Portugal