Emerging Applications of Molecular Imaging to Oncology - 1st Edition - ISBN: 9780124116382, 9780124116344

Emerging Applications of Molecular Imaging to Oncology, Volume 124

1st Edition

Serial Volume Editors: Martin Pomper Paul B. Fisher
eBook ISBN: 9780124116344
Hardcover ISBN: 9780124116382
Imprint: Academic Press
Published Date: 25th September 2014
Page Count: 402
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Table of Contents

  • Preface
  • Chapter One: Quantitative Radiology: Applications to Oncology
    • Abstract
    • 1 Introduction
    • 2 Radiological Characterization of Tumors
    • 3 Quantitative Radiology
    • 4 Future Directions
    • 5 Conclusion
  • Chapter Two: The Intricate Role of CXCR4 in Cancer
    • Abstract
    • 1 Introduction
    • 2 CXCR4/CXCL12 Signaling
    • 3 Expression and Physiological Functions of the CXCR4/CXCL12 Axis
    • 4 Role of CXCR4 in Cancer
    • 5 CXCR4 Antagonists as Therapeutic and Imaging Agents
    • 6 Peptides and Peptidomimetics
    • 7 Conclusion
    • Acknowledgments
  • Chapter Three: Recent Advances in Nanoparticle-Based Nuclear Imaging of Cancers
    • Abstract
    • 1 Introduction
    • 2 Lipid-Based Nanoparticles
    • 3 Dendrimers
    • 4 Polymers
    • 5 Quantum Dots
    • 6 Iron Oxide Nanoparticles
    • 7 Gold Nanoparticles
    • 8 Carbon Nanotubes
    • 9 Silica-Based Nanoparticles
    • 10 Conclusion
  • Chapter Four: Molecular-Genetic Imaging of Cancer
    • Abstract
    • 1 Introduction
    • 2 Promoters
    • 3 Reporters
    • 4 Signal Enhancement of Reporters
    • 5 Prolonged Expression of Reporters
    • 6 Machinery for Gene Delivery
    • 7 Size and Immunogenicity
    • 8 Concluding Remarks
    • Acknowledgments
  • Chapter Five: Real-Time Fluorescence Image-Guided Oncologic Surgery
    • Abstract
    • 1 Introduction
    • 2 Fluorescence Imaging Systems for Intraoperative Procedures
    • 3 Current Intraoperative Optical Image Guidance Systems
    • 4 Fluorescent Agents Used in Image-Guided Surgery
    • 5 Clinical Applications of Fluorescence Image-Guided Surgery
    • 6 Future Directions
    • 7 Concluding Remarks
  • Chapter Six: Cerenkov Imaging
    • Abstract
    • 1 Introduction
    • 2 Cerenkov Radiation Physics (Simplified)
    • 3 Application of Cerenkov in Biological Sciences: CLI
    • 4 Conclusion
    • Acknowledgments
  • Chapter Seven: Molecular Imaging of the Tumor Microenvironment for Precision Medicine and Theranostics
    • Abstract
    • 1 Introduction
    • 2 Imaging and PM/Theranostics of the Physiological Microenvironment
    • 3 The ECM and Its Enzymes
    • 4 Endothelial Cells and Tumor Vasculature
    • 5 Lymphatic Endothelial Cells, Lymphatics, and Interstitial Pressure
    • 6 Stromal Components of the TME and Their Role in PM
    • 7 Intraoperative Optical Imaging
    • 8 Concluding Remarks
    • Acknowledgments
  • Chapter Eight: Tracking Cellular and Immune Therapies in Cancer
    • Abstract
    • 1 Introduction
    • 2 Molecular Imaging Approaches to Cancer Immunotherapy
    • 3 Radionuclide Methods in the Preclinical and Clinical Settings
    • 4 MRI Methods in the Preclinical and Clinical Settings
    • 5 Opportunities for Improvements and Future Directions
    • 6 Conclusions
  • Chapter Nine: Developing MR Probes for Molecular Imaging
    • Abstract
    • 1 General Overview
    • 2 T1, T2, T2* Relaxivity-Based Agents
    • 3 CEST Probes: Multiple Labeling Frequencies
    • 4 19F Probes: Hot-Spot Imaging
    • 5 Hyperpolarized Imaging Probes
  • Chapter Ten: Clinical Translation of Molecular Imaging Agents Used in PET Studies of Cancer
    • Abstract
    • 1 Introduction
    • 2 FDG—Lessons Learnt
    • 3 Stages to Development of a New Radiotracer
    • 4 Translating Deregulated Nature-Identical Biochemicals
    • 5 Translating Cell Surface and Intracellular Receptors as Predictive Biomarkers
    • 6 Translating Probes for Visualization of Life and Death Signals in the Cell
    • 7 Translating Tools to Assess Host–Tumor Microenvironment Interactions
    • 8 Translating Labeled Drugs and Drug Analogs
    • 9 Conclusion
    • Acknowledgments
  • Index


Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume, number 124, covers emerging applications of molecular imaging to oncology, including molecular-genetic imaging, imaging the tumor microenvironment, tracking cells and vaccines in vivo, and more.

Key Features

  • Provides information on cancer research
  • Outstanding and original reviews
  • Suitable for researchers and students


Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.


No. of pages:
© Academic Press 2014
Academic Press
eBook ISBN:
Hardcover ISBN:


"...provides invaluable information on the exciting and fastmoving field of molecular imaging in oncology. This book offers ten authorative reviews on the topic…"--Anticancer Research, February 2015

Ratings and Reviews

About the Serial Volume Editors

Martin Pomper Serial Volume Editor

Affiliations and Expertise

Johns Hopkins University, Baltimore, MD, USA

Paul B. Fisher Serial Volume Editor

Paul B. Fisher, M.Ph., Ph.D., is an accomplished molecular biologist investigating the mechanisms involved in cancer development and progression in order to define improved methods for cancer prevention, detection and therapy. Fisher pioneered a powerful technique to study gene expression in specific tissues or cell types known as subtraction hybridization, which he has used to identify genes involved in many important and medically relevant physiological processes including cancer, neurodegeneration and infectious diseases. Studies in his laboratory focus on understanding the molecular and biochemical reasons for cancer development with a specific focus on understanding how cancers spread, a process called metastasis. The ultimate aim is to use this collected knowledge to bring new, more effective prevention techniques, diagnostic approaches and therapies from the laboratory bench to the patient’s bedside. This is epitomized by his studies involving mda-7/IL-24, a gene that was discovered in his laboratory and has displayed significant clinical efficacy in a phase 1 clinical trial when injected directly into advanced cancers using a form of viral gene therapy. Using a novel cancer terminator virus, Ad.5/3-CTV, that is designed to replicate only within cancer cells while delivering the immune-modulating and toxic mda-7/IL-24 gene, Fisher and his clinical colleagues are developing a clinical trial in patients with glioblastoma multiforme, the most common and deadly form of brain cancer. Fisher has been consistently funded by the National Institutes of Health (NIH) over the past 35 years and is among the top 5 percent of NIH funded investigators during this period. He has published over 500 primary papers and reviews, served on numerous NIH study sections and government and private grant review panels and has over 55 issued patents. He is the recipient of multiple National Cancer Institute (NCI) Program Project Grants; investigator initiated R01 grants from the NIH, NCI and National Institute of General Medical Sciences (NIGMS); private foundation grants from the National Foundation for Cancer Research and the Samuel Waxman Cancer Research Foundation; and an Institutional Research and Academic Career Development Award from the NIH focusing on preparing students from groups underrepresented in the sciences for research careers. Fisher is Professor and Chair of the Department of Human and Molecular Genetics at the Virginia Commonwealth University (VCU) School of Medicine, Founding Director of the VCU Institute of Molecular Medicine and Thelma Newmeyer Corman Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey Cancer Center.

Affiliations and Expertise

VCU Institute of Molecular Medicine, VA, USA