Electrospinning for Tissue Regeneration

1st Edition

Editors: L Bosworth S Downes
Hardcover ISBN: 9781845697419
eBook ISBN: 9780857092915
Imprint: Woodhead Publishing
Published Date: 21st June 2011
Page Count: 424
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Table of Contents

Contributor contact details

Part I: Fundamentals of electrospinning

Chapter 1: Introduction to electrospinning


1.1 Introduction

1.2 Basic concepts

1.3 Morphology and structural formation

1.4 Parameters

1.5 Apparatus

1.6 Materials

1.7 Applications

1.8 Future trends

Chapter 2: Polymer chemistry


2.1 Introduction

2.2 Natural polymers

2.3 Synthetic degradable polymers

2.4 Conclusions

Chapter 3: The electrospinning process, conditions and control


3.1 Introduction

3.2 Solution parameters

3.3 Processing parameters

3.4 Ambient parameters

3.5 Conclusions

Chapter 4: Regulatory issues relating to electrospinning


4.1 Introduction

4.2 Regulation of materials in regenerative medicine

4.3 Future trends

4.4 Sources of further information and advice

Part II: Electrospinning for tissue regeneration

Chapter 5: Bone tissue regeneration


5.1 Introduction

5.2 Principles of bone biology

5.3 Strategies for bone regeneration

5.4 Fabrication of scaffolds for bone tissue engineering

5.5 Potential materials for scaffolds

5.6 Osteoporosis: a growing problem

5.7 Strategies for the treatment of bone defects

5.8 Conclusions and future trends

Chapter 6: Cartilage tissue regeneration


6.1 Introduction

6.2 Culture of chondrogenic cells for implantation

6.3 Electrospun nanofibre scaffolds

6.4 Future trends

Chapter 7: Muscle tissue regeneration


7.1 Introduction to skeletal muscle

7.2 Skeletal muscle injuries

7.3 Mechanical properties of skeletal muscle

7.4 Tissue engineering

7.5 Contractile force



Electrospinning is a simple and highly versatile method for generating ultrathin fibres with diameters ranging from a few micrometres to tens of nanometres. Although most commonly associated with textile manufacturing, recent research has proved that the electrospinning technology can be used to create organ components and repair damaged tissues. Electrospinning for tissue regeneration provides a comprehensive overview of this innovative approach to tissue repair and regeneration and examines how it is being employed within the biomaterials sector.

The book opens with an introduction to the fundamentals of electrospinning. Chapters go on to discuss polymer chemistry, the electrospinning process, conditions, control and regulatory issues. Part two focuses specifically on electrospinning for tissue regeneration and investigates its uses in bone, cartilage, muscle, tendon, nerve, heart valve, bladder, tracheal, dental and skin tissue regeneration before concluding with a chapter on wound dressings. Part three explores electrospinning for in vitro applications. Chapters discuss cell culture systems for kidney, pancreatic and stem cell research.

With its distinguished editors and international team of expert contributors, Electrospinning for tissue regeneration is a valuable reference tool for those in academia and industry concerned with research and development in the field of tissue repair and regeneration.

Key Features

  • Provides a comprehensive overview of this innovative approach to tissue repair and regeneration covering issues from polymer chemistry to the regulatory process
  • Examines employment within the biomaterials sector, reviewing extensive applications in areas such as uses in bone, muscle tendon, heart valve and tissue regeneration
  • Explores electrospinning for in vitro applications and discusses cell culture systems for kidney, pancreatic and stem cell research


Those in academia and industry concerned with research and development in the field of tissue repair and regeneration.


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© Woodhead Publishing 2011
Woodhead Publishing
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About the Editors

L Bosworth Editor

Dr. Lucy A. Bosworth and Professor Sandra Downes both work in the Materials Science Centre at The University of Manchester, UK and are widely renowned for their research into biomaterials, tissue engineering and electrospinning.

S Downes Editor

Affiliations and Expertise

University of Manchester, UK