Electroporation-Based Therapies for Cancer

1st Edition

From Basics to Clinical Applications

Print ISBN: 9780081015278
eBook ISBN: 9781908818294
Imprint: Woodhead Publishing
Published Date: 25th July 2014
Page Count: 352
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Electroporation-Based Therapies for Cancer reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals.

Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and chemo-resistant cancers, that do not respond well to current treatment regimen. An electrical-pulse-mediated, enhanced drug delivery technique known as electroporation is one way to effectively treat these patients.

This technique is especially suitable for low- and middle-income countries, where lack of infrastructure and resources leads to cancer diagnoses at late stages. This quick, safe, effective, economical, out-patient-based technique is a boon to these patients for palliative and other care with enhanced quality of life. This book features discussions by interdisciplinary authors—including practicing oncological surgeons, medical professionals, and academic and other researchers—of the basics and clinical medical applications of electroporation.

Key Features

  • Provides novel and recent clinical applications of electrochemotherapy for various cancers, including melanomas, sarcomas, superficial extreme melanoma, chest wall breast carcinoma, and colorectal cancers
  • Extensive study of a number of cell lines, including human breast cancer, lung cancer, cervical cancer, leukemia, and mouse breast cancer using both reversible and irreversible electroporation techniques
  • In vitro study of delivery of various commonly prescribed/administered breast cancer chemo and hormone drugs, such as Doxorubicin, Paclitaxel, Bleomycin, and Tamoxifen


Oncological surgeons, medical professionals, academic and other researchers.

Table of Contents

  • Dedication
  • Epigraph
  • List of figures and tables

    • Figures
    • Tables
  • Acknowledgments
  • About the editor
  • About the contributors
  • Introduction

    • Motivation:
    • Organization of the chapters
    • Audience
  • 1. Electrochemotherapy – A novel cancer treatment

    • Abstract:
    • 1.1 Why electrochemotherapy?
    • 1.2 References
  • 2. Clinical electrochemotherapy for chest wall recurrence from breast cancer

    • Abstract:
    • 2.1 Introduction
    • 2.2 Scope of the problem
    • 2.3 Treatment options for chest wall recurrence
    • 2.4 Clinical experience with electrochemotherapy
    • 2.5 Electrochemotherapy: the engineer’s point of view
    • 2.6 Conclusions and perspectives
    • 2.7 Acknowledgments
    • 2.8 References
  • 3. Clinical electrochemotherapy for advanced superficial melanoma

    • Abstract:
    • 3.1 Introduction
    • 3.2 Therapeutic options in advanced melanoma
    • 3.3 Clinical experience with electrochemotherapy
    • 3.4 Conclusions and perspectives
    • 3.5 References
  • 4. Low and high voltage electrochemotherapy for breast cancer: an in vitro model study

    • Abstract:
    • 4.1 Introduction
    • 4.2 Anatomy of the breast and its cancer
    • 4.3 Drug delivery issues
    • 4.4 Chemotherapy issues
    • 4.5 Common adverse effects of anticancer drugs
    • 4.6 Anticancer drug resistance
    • 4.7 Electroporation and electrochemotherapy
    • 4.8 Materials and methods
    • 4.9 Results and discussion
    • 4.10 Conclusions
    • 4.11 Acknowledgments
    • 4.12 References
  • 5. Why electroporation is a useful technique for cancer treatments

    • Abstract:
    • 5.1 Introduction
    • 5.2 What is electroporation (EP)?
    • 5.3 Irreversible


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© Woodhead Publishing 2014
Woodhead Publishing
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"...Key features include: Novel and recent clinical applications of electrochemotherapy for various cancers; An extensive study of a number of cell lines,…using both reversible and irreversible electroporation techniques..." --Anticancer Research