Electrophysiological Methods

Electrophysiological Methods

Physical Techniques in Biological Research

1st Edition - January 1, 1964

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  • Editor: William L. Nastuk
  • eBook ISBN: 9781483191799

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Electrophysiological Methods presents a compilation of essays relating to the field of electricity. One topic is the introduction and analysis of electrical stimulation. Other types of stimulation are thermal stimulation, light stimulation, touch stimulation, and auditory stimulation. Microelectrodes act as links by which small regions in biological tissues are electrically joined to amplifying and recording devices. This topic is explored more thoroughly in the book. The physiological activity of cells in nerves, muscles, secretory organs, and other biological structures is accompanied by electrical changes which appear across the cell membrane. This occurrence is another topic in the text. Intracellular techniques employed to record transmembrane potentials and to stimulate cells are likewise presented. A section of the book presents microelectrophoresis which is a method wherein electrical flow is employed to manipulate the ejection of chemical substances from fine microelectrodes or micropipettes. The book will provide useful information to neurologist, cytologist, doctors, students, and researchers in the field of medicine.

Table of Contents

  • Contributors to Volume

    Preface to Volume V

    Contents of Volumes I, II, III, IV, and VI

    List of Abbreviations

    1. Stimulation

    I. Introduction

    II. Electrical Stimulation

    III. Stimulation of Special Receptors


    2. Microelectrodes for Recording and Stimulation

    I. Introduction

    II. Metal Electrodes

    III. Glass Micropipette Electrodes

    IV. Electrical Properties of Glass Microelectrodes

    V. Circuits Used in Applying Microelectrode Techniques

    VI. Microelectrode Application


    3. Electrodes for Extracellular Recording and Stimulation

    I. Introduction

    II. Definitions and Preliminary Remarks

    III. Some Fundamental Characteristics of the Electrodes Used in Biological Research

    IV. Recording of Electrical Activity

    V. Electrical Stimulation of Excitable Tissues

    VI. Preparation and Use of Electrodes


    4. Microelectrophoresis

    I. Introduction

    II. Basic Principles

    III. Practical Considerations

    IV. Practical Applications and Advantages of the Technique

    V. Difficulties Associated with the Technique Addendum: Microinjection (R. D. Keynes)


    5. Micromanipulators: Principles of Design, Operation, and Application

    I. General Micrurgical Problems

    II. Optical Considerations

    III. Microscope Stands

    IV. Low Magnification Micromanipulators

    V. High Magnification Micromanipulators

    VI. Microinjectors

    VII. Integrated Micromanipulator-Microinjector Assemblies

    VIII. Future Trends in Micromanipulator Design


    6. Transducers

    I. Introduction

    II. Transducers for Mechanical Input

    III. Temperature Transducers

    IV. Transducers for Electrical Input

    V. Optical Transducers

    VI. Nuclear Radiation Transducers


    7. Bioelectric Amplifiers

    I. General Requirements of Bioelectric Amplifiers

    II. Amplifier Circuits

    III. Feedback in Amplifiers


    8. Interference and Its Elimination

    I. Introduction

    II. Theory of Interference and Elimination

    III. Practical Elimination of Electrical Interference

    IV. Reduction of Mechanical Interference

    V. Caution

    VI. Addendum: Destructive Interference


    9. Recording and Display

    I. Introduction

    II. Factors Influencing the Fidelity of a Recorder

    III. Characteristics of Moving-Coil Galvanometers

    IV. Servo Recorders

    V. Cathode Ray Oscilloscope Recorders

    VI. Magnetic Tape Recorders

    VII. Digital Devices

    VIII. Other Display Techniques

    IX. Recording and Noise


    Author Index

    Subject Index

Product details

  • No. of pages: 478
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9781483191799

About the Editor

William L. Nastuk

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