Electrocardiography of Laboratory Animals - 1st Edition - ISBN: 9780124159365, 9780124159990

Electrocardiography of Laboratory Animals

1st Edition

Authors: Jeffrey Richig Meg Sleeper
eBook ISBN: 9780124159990
Hardcover ISBN: 9780124159365
Imprint: Academic Press
Published Date: 6th December 2013
Page Count: 144
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Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.

Key Features

  • Covers safety electrocardiography of large laboratory animals
  • Offers comprehensive analysis of ECGs for practical laboratory use
  • Includes a self-evaluation section for testing of ECG reading and analysis


Primary Audience: Researchers working with primates, dogs and mini-pigs in academia, pharma, or contract research organization across the biological and medical sciences. Secondary Audience: Vets working with primates, dogs and mini-pigs; Zoologists working with primates, dogs and mini-pigs; and Veterinary professors and students teaching/taking cardiology and ECG course for accreditation

Table of Contents





Chapter 1. Electrocardiography in Preclinical Safety


Regulatory Guidance versus Good Science versus Rationale Drug Development

Safety Pharmacology versus Toxicology

Safety Pharmacology Studies: Core-Battery and Second-Tier Testing for Cardiotoxicity

Cardiotoxicity Endpoints in Toxicology

The ECG and Drug Safety

Chapter 2. Principles of Electrocardiography

Recording the ECG

Cardiac Conduction and Waveform Genesis

Evaluation of the Electrocardiogram

Transmembrane Action Potentials

Evaluation of Waveforms

Mean Electrical Axis

Equipment Considerations

Cardiac Effects of Systemic Potassium and Calcium Abnormalities

Chapter 3. Canine Electrocardiography


Etiology, Pathophysiology, and Gross Pathology

Rhythm Diagnosis

Chapter 4. Handling and Restraint of Nonhuman Primates

Cynomolgus and Rhesus

Machine Setup and Configuration

Lead Placement

Obtaining the Tracing

Chemical Restraint

Tracing Handling and Storage

Chapter 5. Electrocardiography of Nonhuman Primates

Fundamental Principles of Electrocardiography

Electrocardiography of Cynomolgus and Rhesus Monkeys

Cardiac Arrhythmias

Chimpanzee Electrocardiography

Chapter 6. Electrocardiography of Minipigs

Normal Values

Normal Variants in Order of Occurrence (Commonality)

Lead Placement

Fundamental Principles of Electrocardiography

Electrocardiography of Minipigs (Sus scrofa)

Cardiac Arrhythmias

Sinoatrial Arrhythmias

Supraventricular Arrhythmias

Ventricular Arrhythmias

Abnormalities of Impulse Conduction

Miscellaneous Disturbances

Normal Variants

Chapter 7. Telemetry in Preclinical Safety Studies

Chapter 8. PR (PQ), QRS, QT, and Other Issues

The PR (PQ) Interval

QRS Complex Duration

QT Interval Duration

Chapter 9. Self-Test

Canine ECG Examples





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© Academic Press 2014
Academic Press
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About the Author

Jeffrey Richig

Jeffrey W. Richig, DVM is CEO of ECGVET, LLC and Special Government Employee consultant to the FDA for the cardiovascular and renal drugs division. He has over twenty-five years of experience in electrocardiography for pre-clinical safety evaluation studies and is known as a leading expert in the field.

Affiliations and Expertise

CEO of ECGVET, LLC and Special Government Employee consultant to the FDA for the cardiovascular and renal drugs division, USA

Meg Sleeper

Meg Sleeper, VMD, is an Associate Veterinarian in cardiology at the University of Pennsylvania veterinary school where her research focuses on therapeutic gene transfer.

Affiliations and Expertise

Assistant Professor and Section Chief, Cardiology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA


"…this book might be beneficial to ECG neophytes, veterinary and laboratory technicians who are involved in performing ECGs, and veterinary and graduate students."--Journal of the American Veterinary Medical Association, 15-Sep-14

"There are a number of normal variants in the electrocardiograms of common laboratory animals, say Richig and Sleeper, and if researchers know what is normal for the particular species they are working with, they can avoid excluding those individuals which are within these normal variant ranges."--ProtoView.com, April 2014