Electrocardiography of Laboratory Animals

Electrocardiography of Laboratory Animals

1st Edition - November 22, 2013

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  • Authors: Jeffrey Richig, Meg Sleeper
  • eBook ISBN: 9780124159990
  • Hardcover ISBN: 9780124159365

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Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.

Key Features

  • Covers safety electrocardiography of large laboratory animals
  • Offers comprehensive analysis of ECGs for practical laboratory use
  • Includes a self-evaluation section for testing of ECG reading and analysis


Primary Audience: Researchers working with primates, dogs and mini-pigs in academia, pharma, or contract research organization across the biological and medical sciences. Secondary Audience: Vets working with primates, dogs and mini-pigs; Zoologists working with primates, dogs and mini-pigs; and Veterinary professors and students teaching/taking cardiology and ECG course for accreditation

Table of Contents

  • Dedication




    Chapter 1. Electrocardiography in Preclinical Safety


    Regulatory Guidance versus Good Science versus Rationale Drug Development

    Safety Pharmacology versus Toxicology

    Safety Pharmacology Studies: Core-Battery and Second-Tier Testing for Cardiotoxicity

    Cardiotoxicity Endpoints in Toxicology

    The ECG and Drug Safety

    Chapter 2. Principles of Electrocardiography

    Recording the ECG

    Cardiac Conduction and Waveform Genesis

    Evaluation of the Electrocardiogram

    Transmembrane Action Potentials

    Evaluation of Waveforms

    Mean Electrical Axis

    Equipment Considerations

    Cardiac Effects of Systemic Potassium and Calcium Abnormalities

    Chapter 3. Canine Electrocardiography


    Etiology, Pathophysiology, and Gross Pathology

    Rhythm Diagnosis

    Chapter 4. Handling and Restraint of Nonhuman Primates

    Cynomolgus and Rhesus

    Machine Setup and Configuration

    Lead Placement

    Obtaining the Tracing

    Chemical Restraint

    Tracing Handling and Storage

    Chapter 5. Electrocardiography of Nonhuman Primates

    Fundamental Principles of Electrocardiography

    Electrocardiography of Cynomolgus and Rhesus Monkeys

    Cardiac Arrhythmias

    Chimpanzee Electrocardiography

    Chapter 6. Electrocardiography of Minipigs

    Normal Values

    Normal Variants in Order of Occurrence (Commonality)

    Lead Placement

    Fundamental Principles of Electrocardiography

    Electrocardiography of Minipigs (Sus scrofa)

    Cardiac Arrhythmias

    Sinoatrial Arrhythmias

    Supraventricular Arrhythmias

    Ventricular Arrhythmias

    Abnormalities of Impulse Conduction

    Miscellaneous Disturbances

    Normal Variants

    Chapter 7. Telemetry in Preclinical Safety Studies

    Chapter 8. PR (PQ), QRS, QT, and Other Issues

    The PR (PQ) Interval

    QRS Complex Duration

    QT Interval Duration

    Chapter 9. Self-Test

    Canine ECG Examples




Product details

  • No. of pages: 144
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: November 22, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780124159990
  • Hardcover ISBN: 9780124159365

About the Authors

Jeffrey Richig

Jeffrey W. Richig, DVM is CEO of ECGVET, LLC and Special Government Employee consultant to the FDA for the cardiovascular and renal drugs division. He has over twenty-five years of experience in electrocardiography for pre-clinical safety evaluation studies and is known as a leading expert in the field.

Affiliations and Expertise

CEO of ECGVET, LLC and Special Government Employee consultant to the FDA's cardiovascular and renal drugs division, USA

Meg Sleeper

Meg Sleeper VMD graduated from the University of Pennsylvania veterinary school cum laude in 1993. She is an associate professor of cardiology and was section chief from 2001 through 2011. Dr. Meg Sleeper has published numerous papers including over 70 peer-reviewed original papers, over 50 review papers or case reports, and 4 books. In addition to lecturing at conferences including the American Heart Association, the American College of Veterinary Internal Medicine Forum, the Keystone Veterinary Conference, the World Feline conference and the American Veterinary Medical Association (AVMA), she has been the coordinator for the small animal cardiology section at the AVMA conference since 2009. She has trained 18 veterinary cardiologists through their residency programs at the University of Pennsylvania Veterinary School. In 2015 she joined the faculty at the University of Florida veterinary school. Dr. Sleeper is on the editorial or review board of 11 journals and has served on the research (2008-2011) and examination (2005-2008) committees for the American College of Veterinary Internal Medicine (Cardiology). In early 2011, she was appointed to the Great Ape Heart Project. This project is focused on improving cardiac health in the 4 ape species (Chimpanzees, Gorillas, Bonobos and Orangutans).

Affiliations and Expertise

Clinical Professor, Cardiology, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, University of Florida, Gainsville, FL, USA

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