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Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.
- Covers safety electrocardiography of large laboratory animals
- Offers comprehensive analysis of ECGs for practical laboratory use
- Includes a self-evaluation section for testing of ECG reading and analysis
Primary Audience: Researchers working with primates, dogs and mini-pigs in academia, pharma, or contract research organization across the biological and medical sciences. Secondary Audience: Vets working with primates, dogs and mini-pigs; Zoologists working with primates, dogs and mini-pigs; and Veterinary professors and students teaching/taking cardiology and ECG course for accreditation
Chapter 1. Electrocardiography in Preclinical Safety
Regulatory Guidance versus Good Science versus Rationale Drug Development
Safety Pharmacology versus Toxicology
Safety Pharmacology Studies: Core-Battery and Second-Tier Testing for Cardiotoxicity
Cardiotoxicity Endpoints in Toxicology
The ECG and Drug Safety
Chapter 2. Principles of Electrocardiography
Recording the ECG
Cardiac Conduction and Waveform Genesis
Evaluation of the Electrocardiogram
Transmembrane Action Potentials
Evaluation of Waveforms
Mean Electrical Axis
Cardiac Effects of Systemic Potassium and Calcium Abnormalities
Chapter 3. Canine Electrocardiography
Etiology, Pathophysiology, and Gross Pathology
Chapter 4. Handling and Restraint of Nonhuman Primates
Cynomolgus and Rhesus
Machine Setup and Configuration
Obtaining the Tracing
Tracing Handling and Storage
Chapter 5. Electrocardiography of Nonhuman Primates
Fundamental Principles of Electrocardiography
Electrocardiography of Cynomolgus and Rhesus Monkeys
Chapter 6. Electrocardiography of Minipigs
Normal Variants in Order of Occurrence (Commonality)
Fundamental Principles of Electrocardiography
Electrocardiography of Minipigs (Sus scrofa)
Abnormalities of Impulse Conduction
Chapter 7. Telemetry in Preclinical Safety Studies
Chapter 8. PR (PQ), QRS, QT, and Other Issues
The PR (PQ) Interval
QRS Complex Duration
QT Interval Duration
Chapter 9. Self-Test
Canine ECG Examples
- No. of pages:
- © Academic Press 2014
- 6th December 2013
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Jeffrey W. Richig, DVM is CEO of ECGVET, LLC and Special Government Employee consultant to the FDA for the cardiovascular and renal drugs division. He has over twenty-five years of experience in electrocardiography for pre-clinical safety evaluation studies and is known as a leading expert in the field.
CEO of ECGVET, LLC and Special Government Employee consultant to the FDA's cardiovascular and renal drugs division, USA
Meg Sleeper, VMD, is a Clinical Professor of Cardiology in the Department of Small Animal Clinical Sciences, School of Veterinary Medicine, University of Florida, Gainsville, FL, USA
Clinical Professor, Cardiology, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, University of Florida, Gainsville, FL, USA
"…this book might be beneficial to ECG neophytes, veterinary and laboratory technicians who are involved in performing ECGs, and veterinary and graduate students."--Journal of the American Veterinary Medical Association, 15-Sep-14
"There are a number of normal variants in the electrocardiograms of common laboratory animals, say Richig and Sleeper, and if researchers know what is normal for the particular species they are working with, they can avoid excluding those individuals which are within these normal variant ranges."--ProtoView.com, April 2014
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