Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS: Part II

1st Edition, Volume 161 - November 4, 2021
Editors: Richard L Bell, Shafiqur Rahman
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 2 6 0 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 2 6 1 - 9

Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS: Part II, Volume 161, in the International Review on Neurobiology serial highlights new advances, wit… Read more

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Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS: Part II, Volume 161, in the International Review on Neurobiology serial highlights new advances, with this volume presenting chapters on topics including Introduction to Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Peri-adolescent Exposure to (Meth)amphetamine in Animal Models, The Impact of Adolescent Nicotine Exposure on Alcohol Use During Adulthood: The Role of Neuropeptides, Cannabis Exposure During Adolescence: A uniquely Sensitive Period for Neurobiological Effects, The Stoned Age: Sex Differences in the Effects of Adolescent Cannabinoid Exposure on Prefrontal Cortex Structure and Function in Animal Models, and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Peri-adolescent exposure to (meth)amphetamine in animal models
Abstract
1: Introduction
2: Effects of (meth)amphetamines in the peri-adolescent period
3: Conclusions and future directions
References
Chapter Two: The impact of adolescent nicotine exposure on alcohol use during adulthood: The role of neuropeptides
Abstract
1: Introduction
2: Adolescence: A vulnerable developmental period
3: Adolescent nicotine/alcohol exposure and alterations in neuropeptides
4: Conclusion
References
Chapter Three: Cannabis exposure during adolescence: A uniquely sensitive period for neurobiological effects
Abstract
1: Introduction
2: Cannabinoids and the eCB system
3: The endogenous cannabinoid system across the life span: Adolescence as a uniquely vulnerable period
4: Interactions between eCBs and dopamine: Effects on late maturing systems
5: Adolescent THC exposure, effects on subcortical dopamine via alterations in prefrontal GABA circuits
6: Conclusions
References
Chapter Four: The stoned age: Sex differences in the effects of adolescent cannabinoid exposure on prefrontal cortex structure and function in animal models
Abstract
1: Introduction
2: The adolescent brain is exquisitely sensitive to exogenous cannabinoids
3: Effects of adolescent cannabinoid exposure on prefrontal cortex (PFC)-dependent behavior
4: Effects of adolescent cannabinoid exposure on prefrontal cortex (PFC) structure and function
5: Conclusions
References
Chapter Five: Adolescent opioid abuse: Role of glial and neuroimmune mechanisms
Abstract
1: Introduction
2: Glial cells and brain development
3: Neuroimmune response and adolescent brain development
4: Opioid exposure and glial activation
5: Opioid exposure and glial neuroimmune signaling
6: Glial targets, opioid abuse, and therapeutic significance
7: Conclusions
References
Chapter Six: Adolescent neuroimmune function and its interaction with alcohol
Abstract
1: Introduction
2: Neuroimmune development and functioning during adolescence
3: Early adolescent sensitivity to ethanol-induced alterations in neuroimmune processes
4: Impact of stress and immune stimuli on adolescent neuroimmune functioning
5: Conclusions
References
Chapter Seven: Alcohol, inflammation, and blood-brain barrier function in health and disease across development
Abstract
1: Introduction
2: Form and function of the BBB: Gatekeeper of neurovascular unit function
3: Alcohol effects on BBB permeability
4: Alterations in BBB permeability exacerbate brain pathology
References
Chapter Eight: Age modifies the effect of ethanol on behavior: Investigations in adolescent, adult and aged rats
Abstract
1: Effect of acute ethanol administration on behavior
2: Effects of chronic ethanol administration and corresponding withdrawal state on behavior
3: Conclusion
References
Chapter Nine: Early life stress and susceptibility to addiction in adolescence
Abstract
1: Introduction
2: Adolescence
3: Early life stress
4: Investigation of molecular mechanisms underlying the ELS-induced addiction susceptibility phenotype in adolescence
5: Conclusions
References
Chapter Ten: Future directions for part II: Substance use disorders in adolescence—A vision for a better future
1: Future directions and strategies
2: Additional stakeholders for a lasting change
References

Richard L Bell

Dr. Bell received a Bachelor of Arts in General Psychology and Addiction Counseling from Minot State University (Minot, ND) and went on to receive a Master of Science and a Doctor of Philosophy in Applied Biopsychology, with a minor in Biostatistics, from the University of New Orleans (New Orleans, LA). He is presently an Associate Professor of Psychiatry at the Indiana University School of Medicine (Indianapolis, IN). He has been researching the in vivo effects of alcohol for 20 years and has maintained continuous funding from the National Institutes of Health—National Institute on Alcohol Abuse and Alcoholism for close to 15 years. His research during this time has focused on the behavioral genetics of rat lines selectively bred to consume high, vs very low, amounts of ethanol. The high ethanol-consuming rat lines display intakes corresponding with that of a 70 kg male drinking a fifth, or more, of 90-proof whiskey every day. These rat lines display many of the behavioral, physiological, neurochemical and genetic characteristics observed in clinical family history positive (FHP), for alcoholism, individuals; whereas the low ethanol-consuming rat lines serve as an animal model of family history negative (FHN) individuals. Moreover, these high ethanol-consuming rat lines meet established criteria for an animal model of alcoholism. Regarding this, he has written extensively on the genotypic as well as behavioral and neurochemical phenotypic characteristics of these and other major, international selectively bred high vs low ethanol-consuming rat lines. His more recent research has focused on three major areas: (1) innate and ethanol-induced changes in gene expression within subregions of the mesocorticolimbic and extended amygdala reward neurocircuits; (2) the acute as well as chronic behavioral and neurochemical effects of ethanol and/or nicotine exposure during adolescence and emerging adulthood; and (3) differences in the genetic, behavioral and neurochemical effects of binge-like, non-binge-like and relapse-like ethanol drinking and/or nicotine consumption. Scholastically, Dr. Bell has presented his findings to professional and lay audiences locally, nationally and internationally. He has published approximately 120 journal articles and book chapters. He serves as Associate Editor, Review Editor or Reviewer for over 50 international journals. He serves as a grant reviewer for the Veterans Affairs and the National Institutes of Health as well as multiple international academic institutions and is a member of the Research Society on Alcoholism—Animal Research and Ethics Committee.

Affiliations and expertise

Associate Professor, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA

Shafiqur Rahman

Shafiqur Rahman, Ph.D. is Professor of Pharmacology in the Department of Pharmaceutical Sciences at South Dakota State University (SDSU) in Brookings, USA. He received his Ph.D. in Neuropharmacology from the Memorial University of Newfoundland, Canada. Dr. Rahman completed his post-doctoral fellowship in the Department of Psychiatry from Indiana University School of Medicine in Indianapolis in USA. Prior to joining SDSU, he worked as research scientist and faculty at the University of Kentucky in Lexington, USA and the University of Toronto, Canada. Dr. Rahman's research focus is drug discovery in neuropharmacology, i.e. the development of novel therapeutic candidates for the treatment of drug addiction and neuropsychiatric disorders. His research and scholarship has resulted in over 125 publications and 11 edited books/book chapters. Dr. Rahman served as editor, editorial board member and reviewer for numerous Scientific Journals and review panels related to drug addiction, neuropharmacology, and drug discovery research. Dr. Rahman is also a member of several professional societies or organizations, including Society for Neuroscience, American Society for Experimental Neurotherapeutics, and American Society for Pharmacology and Experimental Therapeutics.

Affiliations and expertise

Professor, Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, USA