Early Diabetes

Early Diabetes

Advances in Metabolic Disorders, Vol. 1

1st Edition - January 1, 1970

Write a review

  • Editors: Rafael A. Camerini-Dávalos, Harold S. Cole
  • eBook ISBN: 9781483215549

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Advances in Metabolic Disorders, Supplement 1: Early Diabetes covers the discussions during the first International Symposium on Early Diabetes. The book discusses the views of the role of genetic factors in diabetes; the genetic problem posed by the relatively high frequency of diabetes; the relationship between diabetes and prediabetes in the mother; and the congenital defect in the offspring. The text also describes the report on the genetics of diabetes among the Pima Indians, as well as the genetics of animals with spontaneous diabetes. The pathophysiology of diabetes mellitus, the concept of progression from prediabetes to chemical diabetes and then to overt diabetes, and the effect of aging on carbohydrate metabolism are also considered. The book further tackles the epidemiology of early diabetes, as well as the natural history of diabetes. The text concludes by looking into the treatment of early diabetes, including topics on insulin treatment of children with a late stage of chemical diabetes; complementary arguments in favor of the betacytotrophic action of the hypoglycemic sulphonamides; and the use of oral hypoglycemic compounds. Endocrinologists, biochemists, physiologists, and researchers working on the treatment of diabetes will find the book invaluable.

Table of Contents


  • List of Contributors

    Foreword

    Preface

    I. Genetics of Diabetes

    The Genetics of Diabetes Mellitus

    Preliminary Report on the Genetics of Diabetes among the Pima Indians

    Genetics of Animals with Spontaneous Diabetes

    Discussion

    II. Pathophysiology

    Some Factors Controlling Differentiation and/or Modulation of Rat Pancreatic Islet Cells

    A Two-Compartmental Model for Insulin Secretion

    Mechanisms in the Control of Insulin Release by Glucose and Other Substances

    The Mechanism of Insulin Secretion Studied through the Effects of Electrolytes and Inhibitors

    Discussion

    Insulin Secretion in Early Diabetic Animals: In Vivo Studies

    Diabetogenesis

    The Effect of β-Adrenergic Receptor Blocking Agents on Drug-Induced Insulin Secretion

    Dynamics of Insulin Secretion in Early Diabetes in Humans

    Evidence that the Primary Lesion in Familial Diabetes Mellitus is an Inherited Defect of the β-Cell

    Subnormal Secretion of Insulin in Mild Diabetes Mellitus

    Discussion

    Possible Role of Insulin-Stimulating Hormones in Disturbances of Nutrient Tolerance

    Invited Discussant

    Discussion

    Evidence for an Abnormal Insulin in Diabetes Mellitus

    Metabolism of Insulin in Normal and Diabetic Subjects

    A Postulated Mechanism for the Insulin Synergistic and Insulin Antagonistic Action of Growth Hormone

    Human Proinsulin: Some Considerations in the Development of a Specific Immunoassay

    Discussion

    Does Diabetes Begin with Insulin Resistance?

    Does Diabetes Begin with Insulin Resistance?

    Invited Discussants

    Discussion

    The Critical Role of Obesity in the Interpretation of Serum Insulin Levels

    Invited Discussant

    Discussion

    III. Maternal-Placental-Fetal Relationship

    Metabolic Realignments in Late Pregnancy: A Clue to Diabetogenesis

    Invited Discussant

    Discussion

    Fetuses and Newborns of 95% Pancreatectomized Female Rats

    Offspring of Animals with Experimental Diabetes

    Discussion

    Infants of the Diabetic Mother

    Invited Discussants

    Discussion

    IV. Prediabetes and Chemical or Latent Diabetes

    Early Stages of the Diabetic State: Definitions and Concepts

    Discussion

    Further Electron Microscopic Studies of Diabetic Microangiopathy

    Diagnostic Criteria in the Assessment of Glomerular Capillary Basement Membrane Lesions in Newly Diagnosed Juvenile Diabetics

    Variations in Capillary Basement Membrane Width Produced by Aging and Diabetes Mellitus

    Invited Discussant

    Discussion

    Influence of Weight upon Serum Insulin and the Serum Growth Hormone Responses of Male Offspring of Two Diabetic Parents

    Biochemical and Functional Abnormalities in Prediabetic Subjects

    Metabolic Studies in Prediabetic Subjects

    Prospective Diagnosis of Diabetes

    Invited Discussants

    Discussion

    Gestational Diabetes and Its Significance

    Invited Discussant

    Discussion

    V. Effect of Aging on Carbohydrate Metabolism

    Effect of Aging on Carbohydrate Metabolism

    VI. The Epidemiology of Early Diabetes

    The Epidemiology of Early Diabetes

    Hyperglycemia and Vascular Disease in Tecumseh, Michigan

    Invited Discussant

    Discussion

    VII. Natural History of Diabetes

    The Course of Asymptomatic Diabetes of Children, Adolescents. and Young Adults

    Natural History of Diabetes

    Discussion

    VIII. Treatment of Early Diabetes

    Treatment of Early Diabetes

    Insulin Treatment of Children with Late Stage of Chemical Diabetes

    Discussion

    Complementary Arguments in Favor of the Betacytotrophic Action of the Hypoglycemic Sulfonamides

    Attempts to Delay the Progression of Chemical Diabetes

    The Effect of Chlorpropamide Therapy upon Glucose-Insulin Relationships in Adult Diabetics

    Minimal Diabetes and Arterial Disease: Prevalence and the Effect of Treatment

    The Prophylactic Use of Oral Hypoglycemic Drugs in Asymptomatic Diabetes

    Treatment of Subclinical Diabetes

    Oral Treatment of Early Diabetes

    Oral Hypoglycemic Compounds

    Discussion

    IX. Summary

    Conference Summary

    Subject Index




Product details

  • No. of pages: 508
  • Language: English
  • Copyright: © Academic Press 1970
  • Published: January 1, 1970
  • Imprint: Academic Press
  • eBook ISBN: 9781483215549

About the Editors

Rafael A. Camerini-Dávalos

Harold S. Cole

Ratings and Reviews

Write a review

There are currently no reviews for "Early Diabetes"