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Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters.
Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.
- Presents a broad-based, up-to date view of the biology of dynein motors
- Discusses approaches from genetics, molecular biology, biochemistry and biophysics
- Includes a companion website with movies of dynamic cell behavior
- Covers the topic in comprehensive chapters written by world experts
Cell biologists, developmental biologists, molecular biologists, geneticists, biophysicists, and clinical researchers who are working in the field of dyneins, and more generally, cilia
I. History and Evolution
1. Discovery of dynein and its properties: a personal account (Gibbons)
2. Origins of cytoplasmic dynein (Vallee)
3. The evolutionary biology of dyneins (Wickstead)
II. Dyneins in Ciliary Biology
4. Cytoplasmic preassembly and trafficking of axonemal dyneins (Desai, Dean and Mitchell)
5. Composition and assembly of axonemal dyneins. (King)
6. Organization of dyneins in the axoneme (Ishikawa)
7. Genetic approaches to axonemal dynein function in Chlamydomonas and other organisms (Yagi and Kamiya)
8. Regulatory mechanics of outer arm dynein motors (King)
9. Control of axonemal inner dynein arms (Hwang, Hunter, Sale, and Wirschell)
10. Ciliary and flagellar motility and the nexin-dynein regulatory complex (Porter)
11. Regulation of dynein-driven ciliary and flagellar movement (Shingyoji)
12. Dynein-mediated photobehavioral responses in Chlamydomonas (Ueki and Wakabayashi)
13. Dynein and intraflagellar transport (Witman and Hou)
III. Cytoplasmic Dynein Biology
14. Cytoplasmic dynein function defined by subunit composition (Pfister)
15. Regulation of cytoplasmic dynein motility (McKenney)
16. Insights into cytoplasmic dynein function and regulation from fungal genetics (Xiang)
17. Role of dynactin in dynein-mediated motility (Ketcham and Schroer)
18. Role of cytoplasmic dynein and dynactin in mitotic checkpoint silencing (Lewis and Chan)
19. Cytoplasmic dynein during mitosis (Hinchcliffe and Vaughan)
20. Dynein and dynactin at microtubule plus ends (Jha and Surrey)
21. Drosophila cytoplasmic dynein: mutations, tools and developmental functions (Neisch, Avery, Li and Hays)
- No. of pages:
- © Academic Press 2017
- 22nd November 2017
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.
Professor, Department of Molecular Biology and Biophysics Director, Electron Microscopy Facility, University of Connecticut Health Center
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