Dyneins - 2nd Edition - ISBN: 9780128094716

Dyneins

2nd Edition

The Biology of Dynein Motors

Editors: Stephen King
Hardcover ISBN: 9780128094716
Imprint: Academic Press
Published Date: 4th December 2017
Page Count: 684
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Description

Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters.

Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.

Key Features

  • Presents a broad-based, up-to date view of the biology of dynein motors
  • Discusses approaches from genetics, molecular biology, biochemistry and biophysics
  • Includes a companion website with movies of dynamic cell behavior
  • Covers the topic in comprehensive chapters written by world experts

Readership

Cell biologists, developmental biologists, molecular biologists, geneticists, biophysicists, and clinical researchers who are working in the field of dyneins, and more generally, cilia

Table of Contents

I.History and Evolution

1.       Discovery of dynein and its properties: a personal account

2.       Evolutionary biology of dyneins

3.       Diversity of dynein-based systems and motile behavior across phylogeny

II. Dyneins in Ciliary Biology

4.       Cytoplasmic preassembly of axonemal dyneins and their trafficking to the cilium

5.       Composition and assembly of axonemal dyneins

6.       Organization of dyneins in the axoneme

7.       Genetic approaches to axonemal dynein analysis

8.       Regulation of axonemal outer and inner arm dyneins

9.       Flagellar motility and the dynein regulatory complex

10.   Regulation of dynein in ciliary and flagellar movement

11.   Computational modeling of dynein activity and the generation of ciliary/flagellar waveforms

12.   Dynein-mediated retrograde intraflagellar

 III. Cytoplasmic Dynein Biology

13.    Cytoplasmic dynein function defined by subunit composition

14.    Mechanisms of cytoplasmic dynein regulation

15.    Insights into cytoplasmic dynein function from fungal genetics

16.    Role of dynactin in dynein-mediated motility

17.    Mechanisms of dynein-cargo interactions

18.    Role of cytoplasmic dynein in mitotic checkpoint silencing

19.   Role of cytoplasmic dynein in mitotic spindle assembly and activity

20.   Dynein function during meiosis and oocyte maturation

21.   Dynein activity in neurons

22.   How does dynein track the microtubule +TIP?

23.   Dynein-driven mRNA transport

Details

No. of pages:
684
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780128094716

About the Editor

Stephen King

Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.

Affiliations and Expertise

Professor, Department of Molecular Biology and Biophysics Director, Electron Microscopy Facility, University of Connecticut Health Center