1st Edition

Structure, Biology and Disease

Editors: Stephen King
Hardcover ISBN: 9780123820044
eBook ISBN: 9780123820051
Imprint: Academic Press
Published Date: 9th August 2011
Page Count: 656
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Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.

Key Features

  • Broad-based up-to-date resource for the dynein class of molecular motors
  • Chapters written by world experts in their topics
  • Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features


Laboratory and clinical researchers across cell biology, developmental biology, genetics, protein chemistry, neurobiology, biophysics, biomedicine and medicine.

Table of Contents

List of Contributors


1. Discovery of Dynein and its Properties

1.1. Introduction

1.2. Research at Harvard

1.3. Research at the University of Hawaii

1.4. Semi-Retirement in Berkeley

1.5. The Pluses of Working on a Minus-End-Directed Motor

1.6. Epilogue

2. Evolutionary Biology of Dyneins

2.1. Introduction

2.2. Dynein Classification

2.3. Dynein Evolution in Eukaryotes

2.4. Evolution in the Proto-Eukaryote

2.5. The Origins of Dynein

2.6. Summary

3. The AAA+ Powerhouse – Trying to Understand How it Works

3.1. Introduction

3.2. Sequence analysis of the Dynein AAA+ Domains

3.3. Nucleotide Binding in the Motor Domain

3.4. How are the AAA+ Modules Spatially Arranged?

3.5. Communication of the Motor Domain with the Microtubule-Binding Domain

3.6. Transduction of Local Conformational Changes into Motion

3.7. Conclusion

4. Dynein Motor Mechanisms

4.1. The Dynein Engine Room

4.2. The Linker Arm and Powerstroke

4.3. Microtubule Affinity: Binding at A Distance

4.4. A Three-Part Harmony in A Big Block V-8

5. Structural Analysis of Dynein Intermediate and Light Chains

5.1. Introduction

5.2. Abbreviated Background of Light Chains

5.3. Structure of The Apo Light Chains

5.4. Structure of Liganded Light Chains

5.5. LC8 and Tctex1 Promiscuity

5.6. Light Chain Isoforms

5.7. Mammalian Dynein Intermediate Chains

5.8. Molecular Model of the Light Chain–Intermediate Chain Structure

5.9. Light Chains and Cargo

5.10. Post-Translational Modifications

5.11. The Roles of LC8 and Tctex1 on Dynein

5.12. Summary

6. Biophysics of Dynein In Vivo

6.1. Single-Molecule Properties of Dynein In Vitro

6.2. Multiple-Motor Prop


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About the Editor

Stephen King

Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.

Affiliations and Expertise

University of Texas, MD Anderson Cancer Center,Michale E. Keeling Center for Comparative Medicine and Research, Bastrop, TX, USA