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Introduction to Dynamics of Proteins and Nucleic Acids
Chapter One. Drug–DNA Intercalation: From Discovery to the Molecular Mechanism
2 Structure and Dynamics of Intercalation
3 Molecular Mechanism of Intercalation
Chapter Two. Ligand Docking Simulations by Generalized-Ensemble Algorithms
Chapter Three. Conformational Dynamics of Single Protein Molecules Studied by Direct Mechanical Manipulation
2 Mechanical Manipulation of Single Protein Molecules
3 Theoretical Models of Single-Molecule Force Spectroscopy
4 Biological Applications
5 Future Perspectives
Chapter Four. Generation of Ligand Specificity and Modes of Oligomerization in β-Prism I Fold Lectins
2 Setting the Stage: Issues Addressed
3 β-Prism I Fold Lectins: The Basics
4 Available Structures and Relationships Among them
5 Protein–Carbohydrate Interactions
6 Plasticity of the Molecule: A Case Study Primarily Involving Jacalin
7 Variability in Quaternary Association
Chapter Five. Conformational Changes of Enzymes and DNA in Molecular Dynamics: Influenced by pH, Temperature, and Ligand
2 CpHMD Simulations on Insect OBPs
3 Thermal Stabilization of Hyperthermophilic Protein Sso7d and Cren7 Complex with DNA
4 Substrate Selectivity and Major Active-Site Access Channels of Human Cytochrome P4507B1
5 Summary and Conclusion
Chapter Six. Protein Functional Dynamics in Multiple Timescales as Studied by NMR Spectroscopy
1 Functional Dynamics and NMR
2 Examples of Functional Dynamics
3 Concluding Remarks
Chapter Seven. Protein–DNA Electrostatics: Toward a New Paradigm for Protein Sliding
1 Introduction: The Search of Target Sequences
2 Protein Diffusion in the Cell
3 Diffusion Along the DNA: What Role for the Sequence?
4 Electrostatics: The DNA–Protein Interaction
5 Theoretical Approach
6 Toward a New Paradigm for the Target Search Process
Chapter Eight. Structural and Dynamical Aspects of HIV-1 Protease and Its Role in Drug Resistance
2 HIV Protease
3 Side Effects and Resistance of Protease Inhibitors
4 Protein Dynamics
5 Computational Simulation Studies
6 HIV-pr Conformation and Dynamics
7 Future Perspectives
Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.
- Covers reviews of methodology and research in all aspects of protein chemistry
- Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics
Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists
- No. of pages:
- © Academic Press 2013
- 1st September 2013
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
"The authority, originality, and editing of the reviews are first class." -- NATURE
Dr. Tatyana Karabencheva-Christova works at the Department of Applied Sciences, University of Northumbria, UK.
Department of Chemistry, Michigan Technological University, Houghton, MI, USA
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