Dynamics of Degeneration and Growth in Neurons

Dynamics of Degeneration and Growth in Neurons

Proceedings of the International Symposium Held in Wenner-Gren Center, Stockholm, May 1973

1st Edition - January 1, 1974

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  • Editors: Kjell Fuxe, Lars Olson, Yngve Zotterman
  • eBook ISBN: 9781483146478

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Dynamics of Degeneration and Growth in Neurons is a collection of papers presented at the International Symposium on the Dynamics of Degeneration and Growth in Neurons, held in Stockholm, Sweden, on May 16-18, 1973. Contributors explore the dynamics of degeneration and growth of central and peripheral neurons, touching on a wide range of topics such as the neurotoxic action of 6-hydroxy-dopa on central catecholamine neurons; axonal transport of proteins in growing and regenerating neurons; and collateral reinnervation in the central nervous system. Comprised of 50 chapters, this volume begins with an overview of degeneration processes in central and peripheral neurons. Results of microfluorimetric and neurochemical studies on degenerating and regenerating adrenergic nerves are presented. The next section is devoted to axoplasmic transport as a mechanism for axonal support and growth and includes chapters dealing with the effects of degeneration and axoplasmic transport blockade on synaptic ultrastructure, function, and protein composition; the role of axoplasmic flow in trophism of skeletal muscle; and proximodistal transport of acetylcholine in peripheral cholinergic neurons. The remaining chapters discuss the nerve growth factor receptor and its specific binding in sympathetic ganglia; the noradrenergic innervation of cerebellar Purkinje cells; and the possible role of brain and peripheral monoamines in the ontogenesis of normal and drug-induced responses in the immature mammal. This book will be of interest to physiologists and neurologists.

Table of Contents

  • Opening Address

    Degeneration Processes in Peripheral and Central Neurons

    Session I

    The Light and Electron Microscopical Appearance of Anterograde and Retrograde Neuronal Degeneration

    The Degeneration Pattern of the Nigro-neostriatal Dopamine System after Electrothermic or 6-Hydroxy-Dopamine Lesions

    Structure-Activity Correlations in Trihydroxyphenethylamines and Dihydroxytryptamines. Relationship to Cytotoxicity in Adrenergic and Serotonergic Neurons

    Neurotoxic Action of 6-Hydroxy-Dopa on Central Catecholamine Neurons

    Microfluorimetric and Neurochemical Studies on Degenerating and Regenerating Adrenergic Nerves

    Late and Early Biochemical Changes in Central Catecholamine Neurons after Axotomy

    Biochemical and Morphological Changes after Mechanical or Chemical Degeneration of the Dopaminergic Nigro-neostriatal Pathway

    Changes in Catecholamine Synthesizing Enzyme Activities during Neuronal Growth and Degeneration

    Some Aspects of the Reaction of Central and Peripheral Noradrenergic Neurons to Injury

    Effects of Bretylium, Related Quaternary Ammonium Compounds, and Mitosis Inhibitors on the Degeneration Activity in the Sympathetically Innervated Periorbital Smooth Muscle in the Conscious Rat

    Noradrenaline Nerve Terminals in the Rat Cerebral Cortex following Lesion of the Dorsal Noradrenaline Pathway: A Study on the Time Course of their Disappearance

    Session II

    Studies on the Neurotoxic Properties of Hydroxylated Tryptamines

    Studies on Central 5-Hydroxytryptamine Neurons using Dihydroxytryptamines: Evidence for Regeneration of Bulbospinal 5-Hydroxytryptamine Axons and Terminals

    Effects of Drugs on Sympathetic Nerve Cells and Small Intensely Fluorescent (SIF) Cells

    The Effect of Industrial Solvents on Adrenergic Transmitter Mechanisms

    Axoplasmic Transport as a Mechanism for Axonal Support and Growth

    Session I

    Dynamics and Mechanics of Neuroplasmic Flow

    Effects of Degeneration and Axoplasmic Transport Blockade on Synaptic Ultrastructure, Function, and Protein Composition

    Axonal Transport of Proteins in Growing and Regenerating Neurons

    The Role of Axoplasmic Flow in Trophism of Skeletal Muscle

    Session II

    Differential Accumulation of Enzymes in Constricted Nerves According to their Subcellular Localization

    Importance of Axoplasmic Transport for Transmitter Levels in Nerve Terminals

    Intra-Axonal Transport Mechanisms in the Noradrenergic Neuron

    Proximodistal Transport of Acetylcholine in Peripheral Cholinergic Neurons

    Axonal Transport of Dopamine-/3-hydroxylase by Abnormal Human Sural Nerves


    Session I

    Control Mechanisms of the Adrenergic Neuron

    Regulation of Enzyme Synthesis by Neuronal Activity and by Nerve Growth Factor

    Assay of Nerve Growth Factor (NGF) in Mouse Tissue and the Role of NGF and Depolarizing Stimuli in the Long-term Regulation of Tyrosine Hydroxylase Activity in Adrenergic Neurons

    The Nerve Growth Factor Receptor: Demonstration of Specific Binding in Sympathetic Ganglia

    DNA Synthesis and Cell Division in Differentiating Avian Adrenergic Neuroblasts

    Session II

    Collateral Reinnervation in the Central Nervous System

    Growth of Adrenergic Neurons in the Adult Mammalian Nervous System

    Has Nerve Growth Factor a Role in the Regeneration of Central and Peripheral Catecholamine Neurons?

    Session III

    The Noradrenergic Innervation of Cerebellar Purkinje Cells: Localization, Function, Synaptogenesis and Axonal Sprouting of Locus Coeruleus

    Biochemical Aspects of the Catecholaminergic Neurons in the Brain of the Fetal and Neonatal Rat

    Ontogenesis of Central and Peripheral Adrenergic Neurons in the Rat following Neonatal Treatment with 6-Hydroxydopamine

    Session IV

    Agglutinins of Formalinized Erythrocytes: Changes in Activity with Development of Dictyostelium discoideum and Embryonic Chick Brain

    Growth and Development of Cholinergic and Adrenergic Neurons in a Sympathetic Ganglion: Reciprocal Regulation at the Synapse

    Heterogenous Reinnervation of Sympathetic Lumbar Ganglia with Sympathetic Postganglionic Nerves

    Ontogenesis of Central Noradrenaline Neurons after 6-Hydroxydopamine Treatment at Birth

    Effects of Vinblastine on Peripheral Autonomic Nerves: Degeneration and Formation of New Nerve Fibers

    Nerve Growth Specificity and Regulation as Revealed by Intraocular Brain Tissue Transplants

    Degeneration and Oriented Growth of Autonomic Nerves in Relation to Smooth Muscle in Joint Tissue Cultures and Anterior Eye Chamber Transplants

    Electrophysiological and Histochemical Properties of Fetal Human Spinal Cord in Tissue Culture

    Receptor Changes in Relation to Degeneration and Development of Neurons and Drug Treatment

    Session I

    Autonomic Neuro-receptor Mechanisms in Brain Vessels

    Pharmacological Approaches to Monoamine Receptors during Brain Development

    Brain and Peripheral Monoamines: Possible Role in the Ontogenesis of Normal and Drug-induced Responses in the Immature Mammal

    Enhanced Accumulations of Cyclic AMP in Brain Slices Elicited by Norepinephrine after Intraventricular Pretreatment of Rats with 6-Hydroxydopamine

    Enhanced Sensitivity to the Noradrenaline Receptor Stimulating Agent, Clonidine, following Degeneration of Noradrenaline Pathways: Studies on Arterial Pressure, Heart Rate, and Respiration

    Learning Deficits in Offspring of the Nursing Mothers given Penfluridol

    Effects of Pre- and Postnatal Injection of 6-Hydroxydopamine on Sleep and Biogenic Amines of Adult Rat

Product details

  • No. of pages: 616
  • Language: English
  • Copyright: © Pergamon 1974
  • Published: January 1, 1974
  • Imprint: Pergamon
  • eBook ISBN: 9781483146478

About the Editors

Kjell Fuxe

Affiliations and Expertise

Department of Histology, Karolinska Institutet

Lars Olson

Yngve Zotterman

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