Dynamics of Degeneration and Growth in Neurons - 1st Edition - ISBN: 9780080179179, 9781483146478

Dynamics of Degeneration and Growth in Neurons

1st Edition

Proceedings of the International Symposium Held in Wenner-Gren Center, Stockholm, May 1973

Editors: Kjell Fuxe Lars Olson Yngve Zotterman
eBook ISBN: 9781483146478
Imprint: Pergamon
Published Date: 1st January 1974
Page Count: 616
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Dynamics of Degeneration and Growth in Neurons is a collection of papers presented at the International Symposium on the Dynamics of Degeneration and Growth in Neurons, held in Stockholm, Sweden, on May 16-18, 1973. Contributors explore the dynamics of degeneration and growth of central and peripheral neurons, touching on a wide range of topics such as the neurotoxic action of 6-hydroxy-dopa on central catecholamine neurons; axonal transport of proteins in growing and regenerating neurons; and collateral reinnervation in the central nervous system.

Comprised of 50 chapters, this volume begins with an overview of degeneration processes in central and peripheral neurons. Results of microfluorimetric and neurochemical studies on degenerating and regenerating adrenergic nerves are presented. The next section is devoted to axoplasmic transport as a mechanism for axonal support and growth and includes chapters dealing with the effects of degeneration and axoplasmic transport blockade on synaptic ultrastructure, function, and protein composition; the role of axoplasmic flow in trophism of skeletal muscle; and proximodistal transport of acetylcholine in peripheral cholinergic neurons. The remaining chapters discuss the nerve growth factor receptor and its specific binding in sympathetic ganglia; the noradrenergic innervation of cerebellar Purkinje cells; and the possible role of brain and peripheral monoamines in the ontogenesis of normal and drug-induced responses in the immature mammal.

This book will be of interest to physiologists and neurologists.

Table of Contents

Opening Address

Degeneration Processes in Peripheral and Central Neurons

Session I

The Light and Electron Microscopical Appearance of Anterograde and Retrograde Neuronal Degeneration

The Degeneration Pattern of the Nigro-neostriatal Dopamine System after Electrothermic or 6-Hydroxy-Dopamine Lesions

Structure-Activity Correlations in Trihydroxyphenethylamines and Dihydroxytryptamines. Relationship to Cytotoxicity in Adrenergic and Serotonergic Neurons

Neurotoxic Action of 6-Hydroxy-Dopa on Central Catecholamine Neurons

Microfluorimetric and Neurochemical Studies on Degenerating and Regenerating Adrenergic Nerves

Late and Early Biochemical Changes in Central Catecholamine Neurons after Axotomy

Biochemical and Morphological Changes after Mechanical or Chemical Degeneration of the Dopaminergic Nigro-neostriatal Pathway

Changes in Catecholamine Synthesizing Enzyme Activities during Neuronal Growth and Degeneration

Some Aspects of the Reaction of Central and Peripheral Noradrenergic Neurons to Injury

Effects of Bretylium, Related Quaternary Ammonium Compounds, and Mitosis Inhibitors on the Degeneration Activity in the Sympathetically Innervated Periorbital Smooth Muscle in the Conscious Rat

Noradrenaline Nerve Terminals in the Rat Cerebral Cortex following Lesion of the Dorsal Noradrenaline Pathway: A Study on the Time Course of their Disappearance

Session II

Studies on the Neurotoxic Properties of Hydroxylated Tryptamines

Studies on Central 5-Hydroxytryptamine Neurons using Dihydroxytryptamines: Evidence for Regeneration of Bulbospinal 5-Hydroxytryptamine Axons and Terminals

Effects of Drugs on Sympathetic Nerve Cells and Small Intensely Fluorescent (SIF) Cells

The Effect of Industrial Solvents on Adrenergic Transmitter Mechanisms

Axoplasmic Transport as a Mechanism for Axonal Support and Growth

Session I

Dynamics and Mechanics of Neuroplasmic Flow

Effects of Degeneration and Axoplasmic Transport Blockade on Synaptic Ultrastructure, Function, and Protein Composition

Axonal Transport of Proteins in Growing and Regenerating Neurons

The Role of Axoplasmic Flow in Trophism of Skeletal Muscle

Session II

Differential Accumulation of Enzymes in Constricted Nerves According to their Subcellular Localization

Importance of Axoplasmic Transport for Transmitter Levels in Nerve Terminals

Intra-Axonal Transport Mechanisms in the Noradrenergic Neuron

Proximodistal Transport of Acetylcholine in Peripheral Cholinergic Neurons

Axonal Transport of Dopamine-/3-hydroxylase by Abnormal Human Sural Nerves


Session I

Control Mechanisms of the Adrenergic Neuron

Regulation of Enzyme Synthesis by Neuronal Activity and by Nerve Growth Factor

Assay of Nerve Growth Factor (NGF) in Mouse Tissue and the Role of NGF and Depolarizing Stimuli in the Long-term Regulation of Tyrosine Hydroxylase Activity in Adrenergic Neurons

The Nerve Growth Factor Receptor: Demonstration of Specific Binding in Sympathetic Ganglia

DNA Synthesis and Cell Division in Differentiating Avian Adrenergic Neuroblasts

Session II

Collateral Reinnervation in the Central Nervous System

Growth of Adrenergic Neurons in the Adult Mammalian Nervous System

Has Nerve Growth Factor a Role in the Regeneration of Central and Peripheral Catecholamine Neurons?

Session III

The Noradrenergic Innervation of Cerebellar Purkinje Cells: Localization, Function, Synaptogenesis and Axonal Sprouting of Locus Coeruleus

Biochemical Aspects of the Catecholaminergic Neurons in the Brain of the Fetal and Neonatal Rat

Ontogenesis of Central and Peripheral Adrenergic Neurons in the Rat following Neonatal Treatment with 6-Hydroxydopamine

Session IV

Agglutinins of Formalinized Erythrocytes: Changes in Activity with Development of Dictyostelium discoideum and Embryonic Chick Brain

Growth and Development of Cholinergic and Adrenergic Neurons in a Sympathetic Ganglion: Reciprocal Regulation at the Synapse

Heterogenous Reinnervation of Sympathetic Lumbar Ganglia with Sympathetic Postganglionic Nerves

Ontogenesis of Central Noradrenaline Neurons after 6-Hydroxydopamine Treatment at Birth

Effects of Vinblastine on Peripheral Autonomic Nerves: Degeneration and Formation of New Nerve Fibers

Nerve Growth Specificity and Regulation as Revealed by Intraocular Brain Tissue Transplants

Degeneration and Oriented Growth of Autonomic Nerves in Relation to Smooth Muscle in Joint Tissue Cultures and Anterior Eye Chamber Transplants

Electrophysiological and Histochemical Properties of Fetal Human Spinal Cord in Tissue Culture

Receptor Changes in Relation to Degeneration and Development of Neurons and Drug Treatment

Session I

Autonomic Neuro-receptor Mechanisms in Brain Vessels

Pharmacological Approaches to Monoamine Receptors during Brain Development

Brain and Peripheral Monoamines: Possible Role in the Ontogenesis of Normal and Drug-induced Responses in the Immature Mammal

Enhanced Accumulations of Cyclic AMP in Brain Slices Elicited by Norepinephrine after Intraventricular Pretreatment of Rats with 6-Hydroxydopamine

Enhanced Sensitivity to the Noradrenaline Receptor Stimulating Agent, Clonidine, following Degeneration of Noradrenaline Pathways: Studies on Arterial Pressure, Heart Rate, and Respiration

Learning Deficits in Offspring of the Nursing Mothers given Penfluridol

Effects of Pre- and Postnatal Injection of 6-Hydroxydopamine on Sleep and Biogenic Amines of Adult Rat


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© Pergamon 1974
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About the Editor

Kjell Fuxe

Affiliations and Expertise

Department of Histology, Karolinska Institutet

Lars Olson

Yngve Zotterman

Ratings and Reviews