Dubois' Lupus Erythematosus and Related Syndromes

Dubois' Lupus Erythematosus and Related Syndromes

9th Edition - August 16, 2018

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  • Authors: Daniel Wallace, Bevra Hahn
  • eBook ISBN: 9780323550642
  • Hardcover ISBN: 9780323479271

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For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes.

Table of Contents

  • Preface, vii

    List of Contributors, viii

    SECTION 1 What Is Lupus?

    1 History of Lupus, 1

    2 Definition and Classification of Lupus and Lupus-Related

    Disorders, 15

    3 The Epidemiology of Lupus, 23

    SECTION 2 Pathogenesis

    4 Overview of Lupus Pathogenesis, 44

    5 Genetics of Human SLE, 54

    6 Epigenetics of Lupus, 69

    7 The Environment and the Host, 86

    8 The Innate Immune System in SLE, 93

    9 B Cells and Generation of Antibodies, 101

    10 T Cells, 116

    11 Adaptive and Innate Immunoregulatory Cells, 125

    12 Cytokines in Lupus, 137

    13 Immunometabolism, 153

    14 Animal Models in Lupus, 164

    SECTION 3 Mechanisms of Tissue Injury

    15 Abnormalities in Immune Complex Clearance and

    Apoptotic Cell Clearance, 216

    16 The Role of Complement in SLE, 224

    17 Apoptosis and Inflammatory Forms of Cell Death, 237

    18 Tissue Damage in Lupus: Free Radicals and Fibrosis, 248

    19 Pathogenesis of Fibrosis—The Lung as a Model, 261

    20 Pathogenesis of Lupus Nephritis, 269

    21 Pathogenesis of Accelerated Atherosclerosis and

    Vascular Injury in Systemic Lupus Erythematosus, 294

    22 Pathogenesis of Cutaneous Lupus, 305

    23 Pathogenesis of Neuropsychiatric Lupus, 317

    24 Pathogenesis of Antiphospholipid Antibody

    Syndrome, 324

    25 Pathogenesis of Sjögren’s, 338

    SECTION 4 Autoantibodies

    26 Structure and Derivation of Autoantibodies, 340

    27 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes, 355

    28 Antibodies Against ENA (Sm, RNP, SSA, SSB), 366

    29 Antibodies Against C1q, 372

    30 Antilipoprotein and Antiendothelial Cell

    Antibodies, 375

    31 Drug-Induced Lupus Erythematosus, 377

    SECTION 5 Clinical Aspects of Lupus


    32 Overview and Clinical Presentation, 389

    33 Skin Disease in Cutaneous Lupus Erythematosus, 395

    34 The Musculoskeletal System and Bone

    Metabolism, 407

    35 Lupus and the Cardiopulmonary System, 418

    36 Lupus and the Nervous System: Clinical Aspects, Psychopathology, and Imaging, 434

    37 Gastrointestinal and Hepatic Systems, 457

    38 Hematologic and Lymphoid Abnormalities in SLE, 473

    39 Neonatal Lupus: Pathogenesis and Clinical

    Approaches, 486

    40 Pregnancy and Autoimmune Disease, Reproductive and

    Hormonal Issues, 499

    41 Systemic Lupus Erythematosus in Childhood and

    Adolescence, 520

    42 Clinical Aspects of Antiphospholipid Syndrome, 532

    43 Lupus and Infections, 543

    44 Ocular, Aural, and Oral Manifestations of Lupus, 556

    45 Clinical Aspects of Sjögren’s, 566

    SECTION 6 Assessment of Lupus

    46 Clinical Application of Serologic Tests, Serum Protein

    Abnormalities, and Other Clinical Laboratory Tests in

    Systemic Lupus Erythematosus, 579

    47 Differential Diagnosis and Disease Associations, 598

    48 Incomplete Lupus, Undifferentiated Connective Tissue

    Disease, and Mixed Connective Tissue Disease, 606

    49 Clinical Markers, Metrics, Indices, and Clinical

    Trials, 614

    50 Lupus Biomarkers, 631

    SECTION 7 Management of Lupus

    51 Principles of Therapy, Local Measures, and NSAIDs, 640

    52 Antimalarial Medications, 650

    53 Systemic Glucocorticoid Therapy for SLE, 661

    54 Immunosuppressive Drug Therapy, 673

    55 Complementary and Alternative Medications, Specialized and Niche Therapies, 689

    56 Adjunctive Treatments and Preventive Measures, 702

    57 Targeted Therapies in SLE, 710

    58 Management of Cutaneous Lupus Erythematosus, 719

    59 Epidemiology and Management of Lupus Nephritis, 727

    60 Management of Sjögren’s, 745

    SECTION 8 Outcomes

    61 Socioeconomic and Disability Aspects, 759

    62 Prognosis and Mortality of SLE, 770

    Index, 782

Product details

  • No. of pages: 816
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: August 16, 2018
  • Imprint: Elsevier
  • eBook ISBN: 9780323550642
  • Hardcover ISBN: 9780323479271

About the Authors

Daniel Wallace

Daniel J Wallace MD, FACP, MACR is a board-certified internist and rheumatologist. A Clinical Professor of Medicine at the David Geffen School of Medicine at UCLA, he is the Associate Director of the Rheumatology Fellowship Program at Cedars-Sinai Medical Center, where he also serves on the Board of Governors. Dr. Wallace has authored nearly 450 peer reviewed manuscripts, 30 book chapters, eight textbooks (on lupus, osteoarthritis, Sjogren’s syndrome and fibromyalgia) and his practice includes caring for 2,000 lupus patients, the largest lupus cohort in the United States. Dr Wallace is co-chair of the Lupus Industry Council of the Lupus Research Alliance, past chair of the Lupus Foundation of America, and has served on the Board of Directors of the United Scleroderma Foundation and the Medical Advisory Board of the Sjogren’s Syndrome Foundation. He has been Chief of Rheumatology at the City of Hope and Cedars-Sinai Medical Center, and chairman of the Research and Education Foundation of the American College of Rheumatology.

Affiliations and Expertise

Medical Director, Wallace Rheumatic Study Center; Attending Physician, Cedars-Sinai Medical Center; Clinical Professor of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California

Bevra Hahn

Dr. Hahn received her MD from the Johns Hopkins University School of Medicine, where she later trained in Rheumatology. She trained in internal medicine at Washington University in St. Louis. Dr. Hahn heads research groups that do basic studies in the immune abnormalities that cause systemic lupus erythematosus (SLE) and is developing interventions that help restore the immune response to normal. She also heads a group that studies clinical problems in patients with SLE, including accelerated atherosclerosis and potential new therapies (clinical trials). In addition, Dr. Hahn provides clinical consultations for patients with rheumatic diseases, particularly SLE. She also teaches Rheumatology and heads the administration of the Division of Rheumatology, which has 25 full-time faculty, 8 fellows and several undergraduate students, medical students, PhD students, postdoctoral trainees, and an administrative staff.

Affiliations and Expertise

Professor of Medicine, Chief, Division of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, California

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