Drugs During Pregnancy and Lactation

3rd Edition

Treatment Options and Risk Assessment

Editors: Christof Schaefer Paul W.J. Peters Richard K Miller
Hardcover ISBN: 9780124080782
eBook ISBN: 9780124079014
Imprint: Academic Press
Published Date: 9th October 2014
Page Count: 918
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Drugs During Pregnancy and Lactation, 3rd Edition is a quick and reliable reference for all those working in disciplines related to fertility, pregnancy, lactation, child health and human genetics who prescribe or deliver medicinal products, and to those who evaluate health and safety risks. Each chapter contains twofold information regarding drugs that are appropriate for prescription during pregnancy and an assessment of the risk of a drug when exposure during pregnancy has already occurred. Thoroughly updated with current regulations, references to the latest pharmacological data, and new medicinal products, this edition is a comprehensive resource covering latest knowledge and findings related to drugs during lactation and pregnancy.

Key Features

  • Provides evidence-based recommendations to help clinicians make appropriate recommendations
  • Uniquely organized and structured according to drug class and treatment indications to offer authoritative clinical content on potential adverse effects 
  • Highlights new research developments from primary source about working mechanism of substances that cause developmental disorders


Clinicians who prescribe medicinal products to pregnant or lactating women, clinical pharmacologists, toxicologists and teratology information specialists, pharmacists

Table of Contents

  • List of Contributors
  • Preface
  • Disclaimer
  • General commentary on drug therapy and drug risks in pregnancy
    • 1.1. Introduction
    • 1.2. Development and health
    • 1.3. Reproductive stages
    • 1.4. Reproductive and developmental toxicology
    • 1.5. Basic principles of drug-induced reproductive and developmental toxicology
    • 1.6. Effects and manifestations
    • 1.7. Pharmacokinetics of drugs in pregnancy
    • 1.8. Mechanisms of developmental toxic agents
    • 1.9. Causes of developmental disorders
    • 1.10. Embryo/fetotoxic risk assessment and plausibility
    • 1.11. Classification of drugs used in pregnancy
    • 1.12. Paternal use of medicinal products
    • 1.13. Communicating the risk of drug use in pregnancy
    • 1.14. Risk communication prior to pharmacotherapeutic choice
    • 1.15. Risk communication regarding the safety of drugs already used in pregnancy
    • 1.16. Teratology information centers
  • Specific drug therapies during pregnancy
    • Introduction
    • 2.1. Analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants, and antigout medications
      • 2.1.1. Paracetamol (acetaminophen)
      • 2.1.2. Acetylsalicylic acid
      • 2.1.3. Pyrazolone compounds and phenylbutazone
      • 2.1.4. Analgesic drug combination products and drugs used for osteoarthritis
      • 2.1.5. Opioid agonists and antagonists and other centrally acting analgesics
      • 2.1.6. Non-steroidal anti-inflammatory and antirheumatic drugs
      • 2.1.7. Migraine therapy
      • 2.1.8. Muscle relaxants and other analgesics
      • 2.1.9. Antigout preparations
    • 2.2. Allergy and hyposensitization therapy
      • 2.2.1. Antihistamines (H1-blocker)
      • 2.2.2. Hyposensitization therapy
      • 2.2.3. C1-Esterase inhibitor deficiency
    • 2.3. Antiasthmatic and cough medication
      • 2.3.1. Selective


No. of pages:
© Academic Press 2015
Academic Press
Hardcover ISBN:
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About the Editor

Christof Schaefer

Affiliations and Expertise

Berlin Teratology Information Unit, Berlin, Germany

Paul W.J. Peters

Affiliations and Expertise

University Medical Centre Utrecht, The Netherlands

Richard K Miller

Affiliations and Expertise

Department of Obstetrics/Gynecology, University of Rochester, Rochester, NY


"Geared to an international audience, this desk reference for medications and how they affect pregnancy and lactation does a solid job of highlighting the pertinent information while covering worthwhile medications. Score: 70 - 3 Stars" --Doody's

"A welcome edition to an already thorough reference...succinct texts such as this are invaluable and worthy of a spot on a bookshelf of any health care practitioner who advises pregnant or lactating women." --Myla Moretti, Motherisk Program, Toronto, Ontario, in Canadian Journal of Hospital Pharmacy