Drugs and Enzymes - 1st Edition - ISBN: 9781483198484, 9781483223513

Drugs and Enzymes

1st Edition

Proceedings of The Second International Pharmacological Meeting, Vol. 4

Editors: Bernard B. Brodie James R. Gillette
eBook ISBN: 9781483223513
Imprint: Pergamon
Published Date: 1st January 1965
Page Count: 516
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Second International Pharmacological Meeting, Volume 4: Drugs and Enzymes is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963.
This volume is organized into two sections encompassing 41 chapters. The first section discusses the relationship between biochemical effects of drugs in vitro and their pharmacological effect in vivo. This section specifically examines the correlation between the action of substances on isolated smooth muscle and on the central nervous system, as well as the behavior of a centrally-acting drug and enzyme in the ion movement in the system. The second section surveys the biochemical mechanisms of drug toxicity. Considerable chapters in this section are devoted to the effect of drug toxicity, such as altered drug metabolism, enzyme induction, morphological changes, hepatic effects, and photosensitivity. This book will prove useful to pharmacologists, neurologists, biochemists, and researchers who are interested the fields of drugs and drug toxicity.

Table of Contents

List of Authors


Relationship Between Biochemical Effects of Drugs In Vitro and their Pharmacological Effect In Vivo

Reversible Binding as a Complication in Relating the In Vitro Effect of Drugs to their In Vivo Activity

Correlations between the Action of Substances on Isolated Smooth Muscle and on the Central Nervous System

Drugs and Enzymes of Ion Movement in the Central Nervous System

Metabolism, Activity and Some Effects of Drugs in Mammalian Non-myelinated Nerve Fibers — Discussion to paper by H. Mcllwain

Neurophysiological and Biochemical Correlations in Isolated Nerve Cell Preparations at Rest and during Impulse Activity

Effect of Digitalis on Membrane Adenosine Triphosphatase of Cardiac Muscle

Discussion to paper by K. Repke

In Vivo Factors Influencing the Efficacy of Chelating Compounds as Therapeutic Agents for Metal Toxicity

Effets metaboliques de quelques radio-protecteurs

A Contribution to the Effects of Protective Drugs — Discussion to paper by Ζ. M. Bacq and C. Liιbecq

Carbonic Anhydrase Inhibitors

The Kinetics of Carbonic Anhydrase and its Inhibition In Vivo

Comparison by Direct Measurement of Sulfonamide Carbonic Anhydrase Inhibition in Whole Cells and in Enzyme Solutions — Discussion to paper by T. H. Maren

Monoamine Oxidase Inhibitors

Discussion to paper by S. Spector

Enzymes as Therapeutic Agents

Modifiers of Adrenocortical Function

Modifiers of Adrenocortical Function — Some Clinical Aspects — Discussion to paper by R. Neher and F. W. Kahnt

Xenon Bonding to Proteins — Relationship to Anesthetic Action

Discussion to paper by R. M. Featherstone

Biochemical Mechanisms of Drug Toxicity

Individual Variation in Drug Metabolism as Cause of Drug Toxicity

Discussion to paper by W. Kalow

Impairment of Drug Metabolism in Drug Toxicity

Enzyme Induction and Drug Toxicity

Morphological Changes in the Endoplasmic Reticulum of the Liver Cells with Enzyme Induction after Pretreatment with Several Drugs—Discussion to paper A. H . Conney

Biochemical Factors.in the Formation of Active and Toxic Metabolic Products

Discussion to paper by J. Axelrod

Biochemistry of Rodenticides

Mechanisms of Drug-induced Carcinogenesis

Biochemical Factors in Carbon Tetrachloride Toxicity

Investigations on the Early Effects of CC14 on Lipid Transport — Discussion to paper by M. G. Horning et al.

Hepatic Lipid Transport and Lipoprotein-protein Synthesis: Effects of CC14 Intoxication — Discussion to paper by M. G. Horning et al

Cumulative Effects of Reserpine on the Pituitary-adrenocortical and Sympathetic Nervous System

Inactivation of SH-Enzymes in Drug-induced Hemolysis

Discussion to paper by S. Rapoport and D. Scheuch

Hepatotoxic Drugs Causing Porphyria in Man and Animals

Photosensitivity to Drugs

Specificity in Delayed-type Reactions to Simple Chemicals

Metabolische Studien mit Thalidomid und seinen Stoffwechselprodukten

Discussion to paper by J. W . Faigle et al.

Chloroquine Toxicity



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© Pergamon 1965
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About the Editor

Bernard B. Brodie

James R. Gillette

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