Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

1st Edition - May 24, 2020

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  • Editors: Chi Hin Cho, Tao Hu
  • Hardcover ISBN: 9780128199374
  • eBook ISBN: 9780128199381

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Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer.

Key Features

  • Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding
  • Updates current trends in the field with pioneering information on drug resistance
  • Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view


Cancer researchers, medical scientists, clinicians, graduate students, pharmacologists

Table of Contents

  • 1. Drug resistence in colorectal cancer: General aspects

    2. Drug transporters in the development of multidrug resistance in colorectal cancer

    3. Role pf colorectal cancer stem cells in resistance to apoptosis and treatment in colorectal cancer

    4. Serrated lesions and stem cells on drug resistance and colon cancer

    5. Development of novel microRNA-based therapeutics platform for colorectal cancer

    6. Chemo-sensitizing agents for naturalorigin for colorectal cancer: Pharmacokinetics approaches

    7. Induction of programmed necrosis by phytochemicals in colorectal cancer

    8. Predictive biomarkers of drug resistance in colorectal cancer - Recent updates

    9. Raclb: An emerging therapeutic target for chemoresistance in colorectal cancer

    10. Nanotechnology-based targeted drug delivery systems and drug resistance in colorectal cancer

    11. Targeting colorectal cancer via nanodrug delivery systems

Product details

  • No. of pages: 240
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: May 24, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128199374
  • eBook ISBN: 9780128199381

About the Editors

Chi Hin Cho

Professor Chi Hin Cho is Distinguished Professor of Pharmacology at Southwest Medical University in China. His current research interests focus on drug development for inflammation and cancers in the gastrointestinal tract. He has served on leading journals in the fields of gastroenterology and pharmacology and as editor of seven books related to inflammation and cancer. He has held numerous senior positions, including the Chair of Pharmacology at Hong Kong University, Chairman and Professor of Pharmacology at the Chinese University of Hong Kong (CUHK), and Research Professor and Associate Director of the School of Biomedical Sciences in the Faculty of Medicine, CUHK. Professionally, he was the President (2006–2010) and Chair of the Presidential Council (2012–2015) of the Gastrointestinal Pharmacology Section of the International Union of Basic and Clinical Pharmacology, and council member of a number of professional bodies in ulcer research and gastrointestinal pharmacology.

Affiliations and Expertise

Distinguished Professor of Pharmacology, Southwest Medical University, Sichuan, China

Tao Hu

Dr. Hu obtained his Ph.D. from The Chinese University of Hong Kong, his research interests focus on the development of novel chemotherapeutic agents for the treatment of colorectal cancer, in particular the drug-resistant colorectal cancer. He published more than 20 peer-reviewed papers in this field and served as editorial board member or reviewer for more than 10 international journals in the field of pharmacology and gastroenterology.

Affiliations and Expertise

Senior Fellow, University of Washington, USA

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