Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy

Approaches and Applications

1st Edition - July 27, 2020

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  • Editors: Kenneth To, William Cho
  • Paperback ISBN: 9780128196687
  • eBook ISBN: 9780128199039

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Description

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource.

Key Features

  • Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research
  • Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences
  • Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Readership

Cancer researchers, medical scientists, clinicians, graduate students, pharmacologists

Table of Contents

  • 1. Drug repurposing for cancer therapydan introduction
    2. A ligand-centric approach to identify potential drugs for repurposing: case study with aurora kinase inhibitors
    3. Machine learning strategies for identifying repurposed drugs for cancer therapy
    4. Unveiling potential anticancer drugs through in silico drug repurposing approaches
    5. Increasing opportunities of drug repurposing for treating breast cancer by the integration of molecular, histological, and systemic approaches
    6. The success story of drug repurposing in breast cancer
    7. A personalized medicine approach to drug repurposing for the treatment of breast cancer molecular subtypes
    8. Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma
    9. Stories of drug repurposing for pancreatic cancer treatmentdPast, present, and future
    10. Animal models and in vivo investigations for drug repurposing in lung cancer
    11. Identification of chemosensitizers by drug repurposing to enhance the efficacy of cancer therapy
    12. Drugs repurposed to potentiate immunotherapy for cancer treatment
    13. Nanoparticle-based formulation for drug repurposing in cancer treatment
    14. Nanotechnological approaches in cancer: the role of celecoxib and disulfiram
    15. Clinical trials on combination of repurposed drugs and anticancer therapies

Product details

  • No. of pages: 458
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: July 27, 2020
  • Imprint: Academic Press
  • Paperback ISBN: 9780128196687
  • eBook ISBN: 9780128199039

About the Editors

Kenneth To

Prof. Kenneth To is currently an Associate Professor in the Chinese University of Hong Kong. He received post-doctoral training at the National Cancer Institute, National Institute of Health, USA, investigating the mechanisms of multidrug resistance and cancer epigenetics. After he became an independent investigator, his research interests focus on the development of novel strategies to overcome drug resistance to classical cytotoxic anticancer drugs as well as molecular targeted cancer therapeutics. He has served as Guest Associate Editor (Frontiers in Oncology & Frontiers in Genetics), Consulting Editor (Pharmacology Research and Perspectives) and Editorial Board Member in 4 other journals in the fields of cancer research and pharmacology. He published more than 100 peer-reviewed articles in highly ranked scientific journals in cancer biology and pharmacology.

Affiliations and Expertise

Associate Professor, Chinese University of Hong Kong

William Cho

Dr. William Cho is a Biomedical Scientist in Queen Elizabeth Hospital. His main research interests have been focusing on cancer researches. He is a Chartered Scientist granted by the Science Council (UK), a Registered Chinese Medicine Practitioner (HK), Guest Professor of some universities and a Fellow Member of several institutes, including the Institute of Biomedical Science (UK), Hong Kong Institute of Biomedical Science and Hong Kong Society for Molecular Diagnostic Sciences. Dr. Cho has published about 300 peer-reviewed papers (Lancet Oncology, Nature Communications, PNAS, etc.) covering cancer biomarkers, anti-cancer drugs, proteomics, microRNAs, Chinese medicine and over a dozen of books.

Affiliations and Expertise

Queen Elizabeth Hospital, Hong Kong

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