
Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
Description
Key Features
- Offers comprehensive and detailed descriptions of the basic aspects of efflux pumps in a very schematic and didactic manner
- Describes the involvement of efflux pumps in cancer resistance in different cancer types
- Encompasses an updated overview on state-of-the-art approaches that capitalize on their inhibition to improve chemotherapy and overcome resistance
Readership
Cancer researchers; medical oncologists; clinicians; pharmacologists; translational investigators
Table of Contents
1. Introduction
2. Efflux transporters in cancers resistance: Molecular and functional identification and characterization of P-glycoprotein
3. Efflux transporters in cancers resistance: Molecular and functional identification and characterization of Multidrug Resistance Proteins
4. Efflux transporters in cancers resistance: Molecular and functional identification and characterization of breast cancer resistance protein
5. Molecular imaging of the activity of membrane efflux transporters in cancer
6. Endocrine cancers
7. Hematologic cancers
8. Gastrointestinal cancers
9. Musculoskeletal cancers
10. Lung cancers
11. Skin cancers
12. Cancers of the central nervous system
13. Cancer stem cells
14. Blood-brain barrier and CNS tumors
15. Nanomedicines to overcome efflux transporter-mediated resistance in cancer
16. Pluronic®: The first nanomedicine ABC inhibitor translated into the clinics
17. Cancer therapy with antibody-linked conjugates and MDR expression
Product details
- No. of pages: 394
- Language: English
- Copyright: © Academic Press 2019
- Published: November 7, 2019
- Imprint: Academic Press
- Hardcover ISBN: 9780128164341
- eBook ISBN: 9780128141410
About the Series Volume Editors
Alejandro Sosnik
Affiliations and Expertise
Reina Bendayan
Affiliations and Expertise
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