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Drug Discovery in Cancer Epigenetics - 1st Edition - ISBN: 9780128022085, 9780128024928

Drug Discovery in Cancer Epigenetics

1st Edition

Editors: Gerda Egger Paola Arimondo
Hardcover ISBN: 9780128022085
eBook ISBN: 9780128024928
Imprint: Academic Press
Published Date: 19th November 2015
Page Count: 498
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Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic.

Key Features

  • Highlights the potential of epigenetic alterations in cancer for drug development
  • Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy
  • Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation


scientists in the academic and industrial sector aiming to test and develop epigenetic cancer drugs; oncologists; geneticists; clinical researchers; clinicians interested in adopting clinical trial drugs.

Table of Contents

I. Introduction
1: Basic Epigenetic Mechanisms and Phenomena
2: Cancer Epigenetics
II. Methods and Tools for Epigenetic Drug Development
3: Drug Discovery Methods
4: Preclinical Cancer Models with the Potential to Predict Clinical Response
5: Discovery of Biomarkers for Drug Development
6: Networks and Consortia for Epigenetic Drug Discovery
III. Classes of Epigenetic Drugs
7: DNA Methyltransferase Inhibitors
8: Small Molecule Inhibitors of Histone Deacetylases and Acetyltransferases as Potential Therapeutics in Oncology
9: Targeting histone methylation. The development of selective methyltransferase and demethylase inhibitors
10: Bromodomains as Anti-Cancer Targets
11: Epigenetic Readers Interpreting the Lysine Methylome – Biological Roles and Drug Discovery
12: Non coding RNAs: Clinical and Therapeutic Applications
IV. Clinical Implications of Epigenetic Therapy
13: Clinical Applications of Epigenetic Drugs
14: Efficacy of Combined Epigenetic Therapies
15: Predicting and Monitoring Responses to Epigenetic Drugs
16: Episensitization: A New Word for A New Concept
17: The Emerging Potential for Epigenetic Therapeutics in Non-Cancer Disorders


No. of pages:
© Academic Press 2015
19th November 2015
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

Gerda Egger

Dr. Gerda Egger is an Associate Professor of Epigenetics at the Clinical Institute of Pathology, Medical University of Vienna.

Affiliations and Expertise

Associate Professor of Epigenetics, Clinical Institute of Pathology, Medical University of Vienna

Paola Arimondo

Dr. Paola Barbara Arimondo is the Director of the Unité de Service et de Recherche (USR n°3388) entitled “Epigenetic Targeting of Cancer –ETaC-“ which brings together basic and applied research – a joint laboratory of the Institut de Recherche Pierre Fabre (IRPF) and the CNRS. She is extremely experienced in researching regulatory pharmaceuticals and cancer epigenetics.

Affiliations and Expertise

Director of the Unité de Service et de Recherche, Pierre Fabre Recherche et Developpement, Castres, France

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