
Drug Discovery in Cancer Epigenetics
Description
Key Features
- Highlights the potential of epigenetic alterations in cancer for drug development
- Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy
- Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation
Readership
scientists in the academic and industrial sector aiming to test and develop epigenetic cancer drugs; oncologists; geneticists; clinical researchers; clinicians interested in adopting clinical trial drugs.
Table of Contents
- Preface
I. Introduction
1: Basic Epigenetic Mechanisms and Phenomena
2: Cancer Epigenetics
II. Methods and Tools for Epigenetic Drug Development
3: Drug Discovery Methods
4: Preclinical Cancer Models with the Potential to Predict Clinical Response
5: Discovery of Biomarkers for Drug Development
6: Networks and Consortia for Epigenetic Drug Discovery
III. Classes of Epigenetic Drugs
7: DNA Methyltransferase Inhibitors
8: Small Molecule Inhibitors of Histone Deacetylases and Acetyltransferases as Potential Therapeutics in Oncology
9: Targeting histone methylation. The development of selective methyltransferase and demethylase inhibitors
10: Bromodomains as Anti-Cancer Targets
11: Epigenetic Readers Interpreting the Lysine Methylome – Biological Roles and Drug Discovery
12: Non coding RNAs: Clinical and Therapeutic Applications
IV. Clinical Implications of Epigenetic Therapy
13: Clinical Applications of Epigenetic Drugs
14: Efficacy of Combined Epigenetic Therapies
15: Predicting and Monitoring Responses to Epigenetic Drugs
16: Episensitization: A New Word for A New Concept
17: The Emerging Potential for Epigenetic Therapeutics in Non-Cancer Disorders
Product details
- No. of pages: 498
- Language: English
- Copyright: © Academic Press 2015
- Published: November 19, 2015
- Imprint: Academic Press
- Hardcover ISBN: 9780128022085
- eBook ISBN: 9780128024928
About the Editors
Gerda Egger
Affiliations and Expertise
Paola Arimondo
Affiliations and Expertise
Ratings and Reviews
Latest reviews
(Total rating for all reviews)
Antonis T. Mon Mar 12 2018
Drug Discovery in Cancer Epigenetics
Very comprehensive and fulfilling from the bench to the bedside.