Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents.


Biochemists, molecular biologists, pharmaceutical and biomedical researchers.

Table of Contents

Preface. "Natural History" Clinical Trials: An Enduring Contribution to Modern Medical Practice, E.M. Scolnick, E.E. Slater, and G.W. Williams: Introduction. Role of the Pharmaceutical Industry in Clinical Trials. Use of "Natural History" RCTs to Validate the Cholesterol Hypothesis and Support Changes in the Management of Other Conditions. Development of a New Chemical Entity. "Natural History" RCTs: Some Considerations. Patient Safety. Clinical Trials and the Practice of Medicine in the Age of Genomics. Angiotensin-Converting Enzyme Inhibitors, J. Menard and A. Patchett: Introduction. Peptide Inhibitors. Captopril. Enalapril. Lisinopril. Fosinopril. Clinically Available ACE Inhibitors. Contribution of ACE Inhibitors to the Growth of Physiological and Pathophysiological Knowledge. Biological Advances in the Knowledge of ACE That Evolved in Parallel with the Drug Development Process. Clinical Development Process of ACE Inhibitors in Hypertension. Benefits of ACE Inhibition Beyond the Fall in Blood Pressure. ACE Inhibitors and Congestive Heart Failure. ACE Inhibitors and Myocardial Infarction. ACE Inhibitors, Coronary Heart Disease, and Atherosis. ACE Inhibitors and Prevention of Restenosis. ACE Inhibitors and Renal Insufficiency. The Fallacy of the Concepts of Normotension and Hypertension and the Cardiovascular Protective Effects of ACE Inhibitors. Surrogate End Points in Clinical Trials of ACE Inhibition: Are We Being Misled? Conclusion. HMG-CoA Reductase Inhibitors, R. Illingworth and J.A. Tolbert: Backgr


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© 2001
Academic Press
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"This volume will be of interest to medicinal chemists, particularly those involved in drug discovery programs. ...Perhaps among the most interesting lessons to be learned from this text is that we are asking a lot from the drug design and discovery process, and that we are very often able to deliver." @source:—-Richard A. Hudson, University of Toledo, in JOURNAL OF MEDICINAL CHEMISTRY (2001) @from:PRAISE FOR THE SERIES @qu:"The authority, originality, and editing of the reviews are first class." @source:—-NATURE @qu:"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists." @source:—-JOURNAL OF THE AMERICAN CHEMICAL SOCIETY