Drug Design

Drug Design

Medicinal Chemistry: A Series of Monographs, Vol. 10

1st Edition - January 28, 1980

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  • Editor: E. J. Ariëns
  • eBook ISBN: 9781483216119

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Drug Design, Volume X covers promising and current developments in drug design. The book discusses procedures as applied in the practice of drug design; the structural aspects of the structure-activity relationships of neuroleptics; and promising perspectives in the highly actual field of bioactive peptides. The text also describes the application of the dynamic systems analysis to the antihypertensive drug action; polymeric drug delivery systems; and the design of biocompatible polymers. The structure-activity relationships of insect repellents as a basis for the design of such agents, as well as the approaches to the multivariate data analysis in structure-activity relationships, which is an essential aspect of drug design, are also encompassed. Chemists, pharmacologists, bioengineers, and people involved in drug design and manufacture will find the book invaluable.

Table of Contents

  • List of Contributors


    Chapter 1. Practical Procedures in Drug Design

    I. Introduction

    II. General Aspects of Drug Development

    III. Procedures in Drug Design

    IV. Application of the Theory of Sets to Drug Design

    V. Drug Design in Practice

    VI. Conclusion


    Chapter 2. Structural Aspects of the Structure-Activity Relationships of Neuroleptics: Principles and Methods

    I. Introduction

    II. Conformational Analysis

    III. Determination of Molecular Structure

    IV. Description and Comparison of Molecular Structures

    V. Summary and Conclusions


    Chapter 3. Bridging the Gap between Bioactive Peptides and Nonpeptides: Some Perspectives in Design

    I. Introduction

    II. Design of Nonpeptidic Peptidomimetics

    III. Conclusions


    Chapter 4. Dynamic Systems Analysis as a Basis for Drug Design: Application to Antihypertensive Drug Action

    I. Introduction

    II. Dynamics of Drug Action

    III. Antihypertensive Drugs: Dynamics of the Interactions with the Cardiovascular System

    IV. Pharmacotherapy of Hypertensive Disease

    V. Dynamic Systems Analysis as a Basis for Drug Design


    Chapter 5. Polymeric Drug Delivery Systems

    I. Introduction

    II. Polymers as Physical Carriers of Drugs

    III. Polymers as Chemical Carriers of Drugs

    IV. Conclusions


    Chapter 6. The Design of Biocompatible Polymers

    I. Introduction

    II. Biocompatibility

    III. Passive Tissue Implants

    IV. Blood Compatible Polymers


    Chapter 7. The Design of Insect Repellents

    I. Introduction and Background

    II. Design Concepts

    III. Future Trends in Repellent Development


    Chapter 8. Multivariate Data Analysis in Structure-Activity Relationships

    I. Multivariate Data Analysis and Statistics

    II. Multivariate Models of Dependence

    III. Multivariate Models of Interdependence

    IV. Program DATASCOPE for Multivariate Data Analysis

    V. Applications of Multivariate Data Analysis

    VI. Conclusion


    Chapter 9. The Masca Model of Pharmacochemistry: II. Rational Empiricisms in the Multivariate Analysis of Opioids

    I. Introduction

    II. Blood-Brain Barrier

    III. Morphinomimetic Polypeptides, Opioid Receptor Activity, and Correlation with Analgesia

    IV. Discrimination of Structure-Analgesic and Structure-Antidiarrheal Relationships

    V. Albumin Binding

    VI. Recognition of Analgesics That Are of Special Interest in Multivariate Data Analysis

    VII. Concluding Remarks



    Contents of Other Volumes

Product details

  • No. of pages: 446
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483216119

About the Editor

E. J. Ariëns

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