Drug Delivery Aspects

Drug Delivery Aspects: Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, and scale-up of nano and micro carriers. Various aspects like conversion of micro-nano particles into solid dosage form, large scale industry manufacturing challenges of nanocarriers, regulatory considerations on drug device combinations are featured in this volume. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. The Multifunctional Drug Delivery Systems books provide a platform to discuss opportunities and challenges in development of micro-nanomedicine and other drug delivery systems, review industrial manufacturing challenges, discuss current and future market trends, facilitate the insight sharing within various expertise area, and establish collaborations between academic scientists, industrial and clinical researchers.

This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems.

• Encompasses engineering aspects of nanocarriers
• Considers preclinical, regulatory and ethical guidelines on drug delivery
• Contains in-depth investigation of specific aspects of drug delivery systems

Pharmaceutical Scientists in academia and industry; pharmacologists; regulatory experts; bioengineers

1. Versatile hyaluronic acid nanoparticles for improved drug delivery
   Mona M.A. Abdel-Mottaleb, Hend Abd-Allah, Riham I. El-Gogary, and Maha Nasr
   2. Preclinical testing—Understanding the basics first
   Ranjita Shegokar
   3. Aqueous polymeric coatings: New opportunities in drug delivery systems
   Abid Riaz Ahmed, Joana Portugal Mota, Ahmad Abdul-Wahhab Shahba, and Muhammad Irfan
   4. Large-scale manufacturing of nanoparticles—An industrial outlook
   Ranjita Shegokar and Mostafa Nakach
   5. The role of polymers and excipients in developing amorphous solid dispersions: An industrial perspective
   Vaibhav Sihorkar and Thomas Durig
   6. Biologics: Delivery options and formulation development strategies
   Ridahunlang Nongkhlaw, Parameswar Patra, Akash Chavrasiya, Nirmal Jayabalan, and Sachin Dubey
   7. The regulatory and ethical issues in nanoparticles, materials and particles (NMP) research
   J. Dias-Ferreira, Ranjita Shegokar, A. Santini, and E.B. Souto
   8. Sterile procedures for pharmaceutical dosage forms
   Sarabjit Singh and Dharmesh Mehta
   9. Vaccine delivery strategies against botulism
   Yongyong Yan, Diana Diaz-Arevalo, Haiyan Wang, Yanping Chen, and Mingtao Zeng
   10. Nanotechnological approaches for delivery of antiinflammatory drugs
   Anđelka B. Kovacevic
   11. Food to medicine transformation of stilbenoid vesicular and lipid-based nanocarriers: Technological advances
   Sara M. Abdel Samie and Maha Nasr