Dosage Form Design Considerations - 1st Edition - ISBN: 9780128144237

Dosage Form Design Considerations

1st Edition

Volume I

Series Volume Editors: Rakesh Tekade
Hardcover ISBN: 9780128144237
Imprint: Academic Press
Published Date: 1st May 2018
Page Count: 575
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Table of Contents

1. Preformulation in drug research and pharmaceutical product development

2. Physicochemical aspects to be considered in Pharmaceutical Product Development

3. Role of physicochemical parameters on drug absorption and their Implications in Pharmaceutical Product Development

4. Physiologic Factors Related to Drug Absorption

5. Physico-chemical, pharmaceutical and biological considerations in GIT Absorption of drugs

6. Influence of Drug Properties and Routes of Drug Administration on the design of controlled release systems

7. Drug stability and degradation studies

8. First pass metabolism considerations in Pharmaceutical Product Development

9. Dissolution profile considerations during Pharmaceutical Product Development

10. Drug disposition considerations in Pharmaceutical Product Development

11. Protein and tissue binding: Implication on pharmacokinetic parameters

12. Preformulation studies of drug substances, proteins and peptides: Role in drug discovery and Pharmaceutical Product Development

13. Role of salt selection in drug discovery and development

14. Drug Complexation: Implications in drug solubilization and oral bioavailability enhancement

15. Solubility and solubilization approaches in Pharmaceutical Product Development

16. Rheology and its implications on performance of liquid dosage forms

17. Micromeritics in Pharmaceutical Product Development

18. Four stages in Pharmaceutical Product Development – Preformulation – Prototype development - Biological aspects - Scale up studies – Commercialization

19. Scale up studies in Pharmaceutical Product Development

20. Manipulation of physiological processes for Pharmaceutical Product Development

21. Impact of pharmaceutical product Quality on Clinical Efficacy

22. Formulation additives used in Pharmaceutical Products: Emphasis on regulatory perspectives and GRAS


Dosage Form Design Parameters, Volume I examines the history as well as the current state of the field within pharmaceutical sciences and concisely explains the history of dosage form design including key developments. The contents are extrapolated to include drug development issues, scale up of formulations, regulatory issues and intellectual property. It also incorporates solid state properties and polymorphism.

Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of dosage form design parameters within the pharmaceutical sciences industry and research, as well as chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination suitable for researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, and related industries as well as advanced students in these fields.

Key Features

  • Examines the history and most recent developments in drug dosage forms for pharmaceutical sciences
  • Focus on physicochemical aspects, prefomulation solid state properties and polymorphism
  • Contains extensive references for further discovery and learning appropriate for advanced undergraduate and graduate students, as well as those needing a quick understanding of drug dosage design


Researchers and postgraduate students in the field of Pharmaceutics. Also appropriate for those in the pharmaceutical industry, scientists from chemical engineering, and those in drug discovery and development


No. of pages:
© Academic Press 2018
Academic Press
Hardcover ISBN:

About the Series Volume Editors

Rakesh Tekade Series Volume Editor

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has also investigated the anticancer activity and molecular mechanism of several compounds and nanoformulations against cancer cell lines. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

Affiliations and Expertise

Assistant Professor, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gujarat, India