Dopaminergic Ergot Derivatives and Motor Function

Dopaminergic Ergot Derivatives and Motor Function

Proceedings of an International Symposium Held in the Wenner-Gren Center, Stockholm, July 24-25, 1978

1st Edition - January 1, 1979

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  • Editors: Kjell Fuxe, Donald B. Calne
  • eBook ISBN: 9781483160979

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Dopaminergic Ergot Derivatives and Motor Function is a collection of papers from the proceedings of an international symposium of the same topic, held in Stockholm on July 24-25, 1978. This collection of papers covers laboratory studies on different subjects such as the anatomy, physiology, biochemistry, and pharmacology of dopaminergic pathways of the brain. This book also discusses clinical research dealing on dopaminergic receptors observed in Parkinsonism and in Huntington's disease. One paper reviews the neural circuitry of the basal ganglia as it is the part of the brain that is first and foremost involved in skeletomuscular mechanisms. Another paper deals with the different groups of ergot derivatives and their structure-activity relationships. The book also addresses the therapeutic activity and toxicity made during these observations. The text then discusses the psychiatric reaction to ergot derivatives, including LSD-induced hallucinations. Another paper examines the effects of dopaminergic ergots on the anterior pituitary function that is limited to the control of prolactin secretion during chronic therapy. This book is valuable to microbiologists, microchemists, and laboratory researchers and scientists dealing with neuro-functions and the brain.

Table of Contents

  • List of Participants


    Section I. Dopaminergic Mechanisms

    The Anatomy of the Extrapyramidal System

    Chemical Aspects of Ergot Derivatives with Central Dopaminergic Activity

    Biochemical Anatomy of the Extrapyramidal System

    Pathophysiology of Motor Performance in Parkinson's Disease

    Dopaminergic Ergots: Drugs which Discriminate between the Multiple Classes of Dopamine Receptors

    Dopamine Receptors and Phosphodiesterases

    Specificity of Agonists and Antagonists at Model Receptors for Dopamine and Octopamine

    Influence of Ergot Derivatives on the Different Types of Dopamine Receptors and on Other Amine Receptors in Primate Brain

    Dopamine and Huntington's Disease: Assessment Using the Kainic Acid Model

    Section II. Dopaminergic Agonism of Ergot Derivatives

    Neuropharmacology of Ergot Derivatives

    Actions of Ergot Derivatives at Dopamine Synapses

    Dopaminergic Ergot Derivatives: Selective Agonists of a New Class of Dopamine Receptors?

    Action of Ergot Dopaminergic Agonists on Monoamine Synthesis in Rat Brain

    Behavioral Effects of Ergot Drugs

    Effects of Ergolines on Dopaminergic and Serotonergic Single Unit Activity

    Dopaminergic and Serotonergic Effects of Ergot Drugs

    Pharmacological Effects of Lisuride in Rodents Mediated by Dopaminergic Receptors: Mechanism of Action and Influence of Chronic Treatment with Lisuride

    The Dopaminephillic Properties of Ergoline Derivatives

    Section III. Therapeutic Actions of Ergot Derivatives

    Clinical Pharmacology of Ergots

    Actions of Bromocriptine in the Shy-Drager and Steele-Richardson-Olszewski Syndromes

    Modification of the "On-Off" Effect with Bromocriptine and Lergotrile

    Bromocriptine Compared with Levodopa in Parkinsonism

    Role of Bromocriptine in the Treatment of Parkinsonism

    Dose-Dependent Locomotor Effects of Bromocriptine in Animals and Man — Are Some of Its Actions due to Metabolites?

    Relationship Between Brain Dopamine Turnover and the Therapeutic Response to Bromocriptine

    Bromocriptine as an Adjuvant to Levodopa

    Ergot Derivatives without Levodopa in Parkinsonism

    Clinical Observations with Bromocriptine in Parkinsonism

    Ergot Derivatives in the Treatment of Psychotic and Hyperkinetic Disorders

    Ergot Derivatives in Dyskinetic and Dystonie Disorders

    Section IV. Adverse Reactions of Ergot Derivatives

    Toxicity of Ergot Alkaloids

    Cardiovascular Effects of Ergot Derivatives in Man

    Cardiovascular Reactions to Bromocriptine

    Psychiatric Reaction to Ergot Derivatives

    The Hepatotoxicity of Ergot Alkaloids

    Endocrine Effects of Dopaminertic Ergot Alkaloids — Toxicological Implications

    Subject Index

Product details

  • No. of pages: 462
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483160979

About the Editors

Kjell Fuxe

Affiliations and Expertise

Department of Histology, Karolinska Institutet

Donald B. Calne

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