DNA Topoisomerases: Topoisomerase-Targeting Drugs, Volume 29B

1st Edition

Serial Volume Editors: Leroy Liu
Hardcover ISBN: 9780120329304
eBook ISBN: 9780080581217
Imprint: Academic Press
Published Date: 14th November 1994
Page Count: 315

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Table of Contents

F.M. Muggia and H.A. Burris, Clinical Development of Topoisomerase-Interactive Drugs. D. Peereboom, M. Charron, and S.H. Kaufmann, Topoisomerases in Human Leukemia. D. Costin and M. Potmesil, Preclinical and Clinical Development of Camptothecins. Y. Pommier, A. Tanizawa, and K.W. Kohn, Mechanisms of Topoisomerase I Inhibition by Anticancer Drugs. T. Andoh and K. Okada, Drug Resistance Mechanisms of Topoisomerase I Drugs. N. Osheroff, A.H. Corbett, and M.J. Robinson, Mechanism of Action of Topoisomerase II-Targeted Antineoplastic Drugs. P. Darpa, Determinants of Sensitivity to Topoisomerase-Targeting Antihumor Drugs. W.T. Beck, M.K. Danks, J.S. Wolverton, M. Chen, B. Granzen, R. Kim,and D.P. Suttle, Resistance of Mammalian Tumor Cells to Inhibitors of DNA Topoisomerase II. K.N. Kreuzer, A Bacteriophage Model System for Studying Topoisomerase Inhibitors. T.A. Shapiro, Drugs Affecting Trypanosome Topoisomerases. J.L.Nitiss, Yeast as a Genetic Model System for Studying Topoisomerase Inhibitors. L.L. Shen and J.M. Fostel, DNA Topoisomerase Inhibitors as Antifungal Agents. A.Y. Chen and L.F. Liu, Design of Topoisomerase Inhibitors to Overcome MDR1-Mediated Drug Resistance. Appendices: J.C. Wang, An Introduction to DNA Supercoiling and DNA Topoisomerase-Catalyzed Linking Number Changes of Supercoiled DNA. P.R. Caron and J.C. Wang, Alignment of Primary Sequences of DNA Topoisomerases. References. Subject Index. Contents of Previous Volumes.

Description

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Readership

Pharmacologists, cancer researchers, biochemists, microbiologists, and cell biologists.


Details

No. of pages:
315
Language:
English
Copyright:
© Academic Press 1994
Published:
Imprint:
Academic Press
eBook ISBN:
9780080581217
Hardcover ISBN:
9780120329304

Reviews

@from:Praise for the Serial @qu:"The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading." @source:--JOURNAL OF PHARMACEUTICAL SCIENCES


About the Serial Volume Editors

Leroy Liu Serial Volume Editor

Leroy F. Liu serves as the Chair and Professor in the Department of Pharmacology at the Robert Wood Johnson Medical School in Piscataway, New Jersey. Dr. Liu earned his B.S. in Chemistry at the National Taiwan University in 1971. He attended the University of California, Berkeley, and received his doctorate in Biophysical Chemistry in 1977. Liu has also held various teaching positions, including Visiting Professor at Academic Sinica in Taiwan and both Assistant and Associate Professor at the Johns Hopkins University School of Medicine.A Searle Scholar (1981-1984), Liu was awarded the American Chemical Society Faculty Research Award (1985-1990) and the George H. Hitchings Award for Innovative Drug Design in 1989. Dr. Liu's research interests include Topoisomerases in DNA structure and function, DNA damage and repair, and cancer biology and pharmacology. Along with this contribution to Advances in Pharmacology, Liu has written more than 100 scientific articles.

Affiliations and Expertise

University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, U.S.A.