DNA Replication Across Taxa

1st Edition, Volume 39 - May 27, 2016
Editor: Laura Kaguni
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 4 7 3 5 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 5 1 1 4 - 6

DNA Replication Across Taxa, the latest volume in The Enzymes series summarizes the most important discoveries associated with DNA replication.… Read more

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DNA Replication Across Taxa, the latest volume in The Enzymes series summarizes the most important discoveries associated with DNA replication.

Preface
Chapter One: Replication Initiation in Bacteria
- Abstract
- 1 Introduction
- 2 Bacterial Replication Origins
- 3 Mechanism of Initiation
- 4 Summary
- Acknowledgments
Chapter Two: The E. coli DNA Replication Fork
- Abstract
- 1 Introduction
- 2 Initiation at oriC, the Origin of Replication
- 3 The Primosome, DnaB, and DnaG
- 4 Role of SSB at the Replication Fork
- 5 The Elongation Stage
- 6 Concluding Comments
- Acknowledgments
Chapter Three: The Replication System of Bacteriophage T7
- Abstract
- 1 Introduction
- 2 T7-Encoded Proteins Involved in DNA Replication
- 3 Initiation of DNA Replication at the Chromosomal Origin
- 4 Replication Intermediates
- 5 Minimal T7 Replisome
- 6 Leading-Strand Synthesis
- 7 Lagging-Strand Synthesis
- 8 Coordination of Leading- and Lagging-Strand Synthesis
Chapter Four: Protein-Primed Replication of Bacteriophage Φ29 DNA
- Abstract
- 1 Introduction
- 2 The Protein-Primed Replication Mechanism
- 3 In Vivo Compartmentalization of ϕ29 DNA Replication
- Acknowledgments
Chapter Five: Archaeal DNA Replication Origins and Recruitment of the MCM Replicative Helicase
- Abstract
- 1 Introduction
- 2 Origin Recognition in Eukaryotes
- 3 Recruitment of the Replicative Helicase
- 4 Archaeal Replication Origin Specification
- 5 Structure of Archaeal Orc1/Cdc6 Proteins
- 6 Role of ATP in MCM Loading
- 7 The Mechanism of MCM Recruitment by Orc1–1
- 8 Concluding Remarks
- Acknowledgments
Chapter Six: The Eukaryotic Replication Machine
- Abstract
- 1 Introduction
- 2 The CMG Helicase
- 3 The Polymerase Alpha-Primase
- 4 The Leading and Lagging Strand DNA Polymerases Epsilon and Delta
- 5 The PCNA Clamp and RFC Clamp Loader
- 6 The Eukaryotic Replisome Structure and Function
- 7 Comparison of Bacterial and Eukaryotic Replisomes
- 8 Future Perspectives
- Acknowledgments
Chapter Seven: The Many Roles of PCNA in Eukaryotic DNA Replication
- Abstract
- 1 Introduction
- 2 PCNA Structure and Function
- 3 The Role of PCNA in Normal DNA Replication
- 4 The Role of PCNA in Translesion Synthesis
- 5 The Role of PCNA in Error-Free Damage Bypass
- 6 The Role of PCNA in Break-Induced Replication
- 7 The Role of PCNA in Mismatch Repair
- 8 The Role of PCNA in Replication-Coupled Nucleosome Assembly
- 9 Putting It All Together
- Acknowledgments
Chapter Eight: Animal Mitochondrial DNA Replication
- Abstract
- 1 Overview
- 2 Structure–Function Relationships in mtDNA Replication Proteins
- 3 Mechanisms of Mitochondrial DNA Replication In Vivo
- 4 Perspectives
- Acknowledgments
Chapter Nine: Fidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus
- Abstract
- 1 Introduction
- 2 Nucleic Acid Polymerases Employ General Acid Catalysis
- 3 Kinetic and Structural Determinants of PV RdRp Fidelity
- 4 Remote-Site Control of an Active-Site Fidelity Checkpoint
- 5 RdRp Fidelity Is a Determinant of Viral Virulence
- 6 RdRp Fidelity Mutants Are Vaccine Candidates
- 7 Correlated Motions of Functionally Important Motifs of the RdRp may be a Determinant of Nucleotide Incorporation Fidelity
- 8 Nucleotide Binding-Occluded and Binding-Competent States of the RdRp–RNA Complex as Determinants of Fidelity
- 9 Conserved, Active-Site Determinants of RdRp Incorporation Fidelity may Exist that can be Targeted for Viral Attenuation
- Acknowledgments
Author Index
Subject Index

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Laura Kaguni