DNA Repair - 1st Edition - ISBN: 9780128155592

DNA Repair, Volume 115

1st Edition

Serial Volume Editors: Rossen Donev
Hardcover ISBN: 9780128155592
Imprint: Academic Press
Published Date: 1st March 2019
Page Count: 488
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Table of Contents

1. DNA Repair by Photolyases
Ibarhim Halil Kavakli
2. Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair
Arnaud Poterszman
3. Chromatin repair - how DNA packaging controls double-strand break repair
Iva Ugrinova
4. Controlling the balance between chromosome breaks repair pathways
Pablo Huertas
5. The targeting of DNA repair pathways in the era of precision oncology
Eddy S. Yang
6. Cancer cells repair and deal with DNA replication stress
Marcel A.T.M. van Vugt
7. Claspin: from DNA damage responses to cancer therapy
Teresa C. Martins
8. cAMP-mediated regulation of melanocyte genomic instability: a melanoma-preventive strategy
John J. D'Orazio
9. Mechanistic link between DNA Repair factors and Immune Signaling
Asaithamby Aroumougame
10. DNA base excision repair in infection-induced inflammation
Min Wu


DNA repair is a complex process collecting different mechanisms enabling cells to identify and deal with damages occurring in the DNA molecules. Corruption of DNA repair has been demonstrated to play a major role in tumorigenesis, aging, immune signaling, etc. This volume of the Advances in Protein Chemistry and Structural Biology is an overview of current developments in mechanisms underlying DNA repair and their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signallind and infection-induced inflammation.

Key Features

  • Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases
  • Targeted to a very wide audience of specialists, researchers and students
  • It contains timely chapters written by well-renown authorities in their field
  • The information provided in the volume is well supported by a number of high quality illustrations, figures and tables


Potein chemists, biochemists, molecular biologists, cell biologists, immunologists, neuroscientists, structural biologists, medical doctors, pharmacologists, computational biochemists and other researchers working in this field. Articles published here would also be of a great benefit to medical, biology and pharmacology students specializing in this field


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© Academic Press 2019
Academic Press
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About the Serial Volume Editors

Rossen Donev Serial Volume Editor

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Senior Lecturer in Swansea University. Currently he is Head of Research at MicroPharm Ltd, UK and Director of Biomed Consult, UK. He has published more than 60 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on design of antibody-based oral treatment of pathological conditions of the colon and small intestines.

Affiliations and Expertise

Swansea University, UK