DNA Methylation and Complex Human Disease

1st Edition

Authors: Michel Neidhart
Hardcover ISBN: 9780124201941
eBook ISBN: 9780127999203
Imprint: Academic Press
Published Date: 3rd September 2015
Page Count: 552
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Description

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies.

This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease.

Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.

Key Features

  • Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity
  • Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field
  • Describes wholly new concepts, including the linking of metabolic pathways with epigenetics
  • Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

Readership

Basic biology and translational researchers above graduate level interested in developmental biology, genetics, health genomics, epigenesis in complex disease, and therapeutic possibilities

Table of Contents

  • Preface
  • About the Author
  • Chapter 1. DNA Methylation – Introduction

    • 1.1 Epigenetics
    • 1.2 Histone Modifications
    • 1.3 DNA Methylation
    • 1.4 Methyl-Binding Domain Proteins
    • 1.5 DNA Demethylation
    • 1.6 DNA Hydroxymethylation
    • 1.7 Differentially Methylated Regions
    • 1.8 Nutriepigenomics
    • References
  • Chapter 2. DNA Methylation and Epigenetic Biomarkers in Cancer

    • 2.1 Introduction
    • 2.2 Cancerogenesis
    • 2.3 Epimutations in Cancer
    • 2.4 Conclusion
    • References
  • Chapter 3. DNA Methylation and Epigenetic Biomarkers in Non-Neoplastic Diseases

    • 3.1 Introduction
    • 3.2 Autoimmunity
    • 3.3 Metabolic Diseases
    • 3.4 Developmental Diseases
    • 3.5 Psychiatric Diseases
    • 3.6 Conclusion
    • References
  • Chapter 4. DNA Methylation and Environmental Factors

    • 4.1 Introduction
    • 4.2 Impact of the Environment in Early Life
    • 4.3 Nutritional Factors
    • 4.4 Adverse Environmental Factors
    • 4.5 Immune Activation
    • 4.6 Maternal Mood and Experience in Early Life
    • 4.7 Physical Exercise
    • 4.8 Conclusion
    • References
  • Chapter 5. DNA Methylation and Epidemiology

    • 5.1 Introduction
    • 5.2 Endocrine Disrupting Chemicals
    • 5.3 Epigenomics and Breast Cancer
    • 5.4 Tobacco Smoking
    • 5.5 Conclusion
    • References
  • Chapter 6. DNA Methylation and Viral Infections

    • 6.1 Introduction
    • 6.2 Virus Infection and Methylation Changes
    • 6.3 Virus Infections, Dna Methylation, and Cancer
    • 6.4 Endogenous Retroviruses
    • 6.5 Conclusion
    • References
  • Chapter 7. DNA Methylation and Cancer

    • 7.1 Introduction
    • 7.2 Maintenan

Details

No. of pages:
552
Language:
English
Copyright:
© Academic Press 2016
Published:
Imprint:
Academic Press
eBook ISBN:
9780127999203
Hardcover ISBN:
9780124201941

About the Author

Michel Neidhart

Professor Neidhart is a senior scientist at the Center of Experimental Rheumatology, Centre for Clinical Research, Switzerland.

Affiliations and Expertise

Center of Experimental Rheumatology, Centre for Clinical Research, University Hospital, Zurich, Switzerland

Reviews

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies.

This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease.

Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.