The only comprehensive work to cover all aspects of diuretic agents, the book discusses the pharmacology and toxicology of diuretic agents as well as the physiological effects. Experts in the field present the principles and experimental approaches for the study of interactions between pharmacologic compounds in relation to specific target organs. Diuretic Agents contains information on the mechanisms of action and application of diuretics, and details FDA regulations and pharmaceutical industry guidelines.

Key Features

@introbul:Key Features @bul:* Written by experts in the field * Covers all aspects of diuretic agents * Includes information on the mechanisms of action and application of diuretics


Researchers in physiology (especially renal), pharmacology, and toxicology.

Table of Contents

Eknoyan, History of Diuretics. Alpern, Giebisch, and Seldin, Renal Electrolyte Transport and Its Regulation. Herbert, Physiology of Diuretic Action. Freidman and Hebert, Site and Mechanism of Action of Diuretics. Zeidel, Special Diuretics. Navar, Renal Hemodynamic Effects of Diuretics. Palmer, Extra-Renal Effects of Diuretics. Ellison, Diuretic Use. Brater, Diuretic Pharmacokinetics and Pharmacodynamics. Resistance to Diuretic Drugs. Ellison, Adaptation to Diuretic Drugs. Patel and Kirchner, Use of Diuretics in Chronic Renal Disease and Nephrotic Syndrome. Kirchner, Effect of Prostaglandin Inhibition on the Action of Diuretic Agents. Kirchner, Impairment of Diuretic Secretion. Salem and Kirchner, Albumin as an Adjunct to Diuretics for the Treatment of Edema. Enhancement of Diuretic Action. Ellison, Intensive Diuretic Therapy: High Doses, Combinations, and Constant Infusions. Ellison, Circulatory Support, Dopamine, and Dopamine Agonists as Adjuncts to Diuretic Therapy. Cleland, Interactions between ACE Inhibitors and Diuretics. Struthers, Atrial Natriuretic Peptide. Emmett and Seldin, Indications Edematous States. Emmett and Seldin, The Pathophysiology of Edema Formation. Emmett and Seldin, Use of Diuretics for the Treatment of Heart Failure. Emmett and Seldin, Diuretic Treatment of Nephrotic Syndrome. Emmett and Seldin, The Use of Diuretics in the Treatment of Ascites and Edema in Hepatic Cirrhosis.


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© 1997
Academic Press
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About the editors

Donald Seldin

Affiliations and Expertise

Southwestern Medical School, University of Texas, Dallas, USA

Gerhard Giebisch

Affiliations and Expertise

Yale University School of Medicine, New Haven, CT, USA


@qu:"The Contributors are a 'who's who' of the diuretic field, and the book encompasses a broad range of topics from very basic molecular concepts to practical and clinical uses of diuretics. The book is a classic in its field. It will be widely cited as a reference and should be used by physicians who use these agents in everyday practice." @source:--Richard J. Glassock, MD, University of Kentucky College of Medicine, for DOODY'S PUBLISHING REVIEWS