Disorders of Mineral Metabolism

List of Contributors

Preface

Contents of Other Volumes


1 Iron

I. Inorganic Biochemistry

II. Iron-Containing Proteins

III. Iron Absorption

IV. Internal Metabolism

V. Methods Used for Clinical Investigation

VI. Iron Deficiency

VII. Iron Overload

VIII. Metabolic Aberrations

References


2 Copper

I. Normal Copper Metabolism

II. Abnormal Copper Metablism

References


3 Zinc in Human Nutrition

I. Introduction

II. Biochemical Functions

III. Experimental Deficiency in Laboratory Animals

IV. Zinc Metabolism

V. Assessment of Zinc Nutriture

VI. Zinc in Foods

VII. Zinc Requirements

VIII. Human Zinc Deficiency

IX. Experimental Zinc Deficiency in Man

X. Nutritional Interactions and Toxicity

References


4 Lead

I. Introduction

II. Environmental Sources and Transport of Lead

III. Human Exposure and Metabolism

IV. Cellular Reactions to Lead

V. Neurological Effects

VI. Hematological Effects

VII. Renal Effects

VIII. Effects of Lead on Reproduction and Development

IX. Effects on the Immune System

X. Interactions with Other Minerals

XI. Lead in Bone and Teeth

XII. Clinical Recognition of Lead Toxicity

XIII. Essentiality of Lead

XIV. Treatment of Lead Toxicity

References


5 Nickel

I. Introduction

II. Nickel Metabolism

III. Nickel Carbonyl Poisoning

IV. Nickel Carcinogenesis

V. Other Aspects of Nickel Toxicology

VI. Summary

References


6 Manganese

I. Introduction

II. Analyses of Mn in Biological Materials

III. Metabolism of Mn in Vitro

IV. Mn Requirements in Normal Nutrition

V. Absorption and Excretion of Mn

VI. Mn Turnover—Specificity

VII. Mn Deficiency

VIII. Mn Excess

IX. Susceptibility to Mn Poisoning

X. Conclusions and Summary

References


7 Chromium

I. Biological Role of Chromium in Mammals

II. Chromium Metabolism

III. Human Chromium Nutrition and Deficiency

IV. Concluding Remarks

References


8 Molybdenum

I. Introduction

II. Dietary Intake and Body Burden

III. Essentiality

IV. Biochemistry

V. Pharmacology

VI. Toxicity

References


9 Cadmium

I. Occurrence and Exposure

II. Review of Effects

III. Metabolism

IV. Cadmium-Induced Renal Damage

V. Effects on Vitamin D Metabolism

VI. Effects on Bones

References


10 Aluminum and Tin

I. Aluminum

II. Tin

References


11 Lithium

I. Chemistry

II. Biology

III. Pharmacokinetics

IV. Interactions of Lithium with Specific Homeostatic Systems

References


12 Fluoride

I. Introduction

II. Fluoride Intake

III. Absorption of Fluoride

IV. Distribution

V. Skeletal Deposition: Fluoride, A Bone Seeker

VI. Mobilization

VII. Excretion

VIII. Pregnancy and the Fetus

IX. Essentiality

X. Cyclic Adenosine Monophosphate

XI. Osteoporosis

XII. Otosclerosis

XIII. Some Toxic Fluoride Effects in Man

XIV. Organic Fluoride

References

Index