Disorders of Mineral Metabolism - 1st Edition - ISBN: 9780121353018, 9781483265872

Disorders of Mineral Metabolism

1st Edition

Trace Minerals

Editors: Felix Bronner Jack W. Coburn
eBook ISBN: 9781483265872
Imprint: Academic Press
Published Date: 28th January 1981
Page Count: 516
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Disorders of Mineral Metabolism, Volume I: Trace Minerals covers the pathophysiology of clinically relevant minerals and elements. This volume focuses on minerals whose average daily intake is under 50 mg.

This text is composed of 12 chapters that tackle the clinical relevance and essentiality of various trace minerals in the human body, with particular emphasis on the disorders due to their abnormal metabolism. The trace mineral and elements considered in this volume include iron, coppers, zinc, lead, nickel, manganese, chromium, molybdenum, cadmium, aluminum, tin, lithium, and fluoride. Each chapter discusses the properties, body requirements, analysis, nutritional interactions, and toxicity of the mineral.

This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

Table of Contents

List of Contributors


Contents of Other Volumes

1 Iron

I. Inorganic Biochemistry

II. Iron-Containing Proteins

III. Iron Absorption

IV. Internal Metabolism

V. Methods Used for Clinical Investigation

VI. Iron Deficiency

VII. Iron Overload

VIII. Metabolic Aberrations


2 Copper

I. Normal Copper Metabolism

II. Abnormal Copper Metablism


3 Zinc in Human Nutrition

I. Introduction

II. Biochemical Functions

III. Experimental Deficiency in Laboratory Animals

IV. Zinc Metabolism

V. Assessment of Zinc Nutriture

VI. Zinc in Foods

VII. Zinc Requirements

VIII. Human Zinc Deficiency

IX. Experimental Zinc Deficiency in Man

X. Nutritional Interactions and Toxicity


4 Lead

I. Introduction

II. Environmental Sources and Transport of Lead

III. Human Exposure and Metabolism

IV. Cellular Reactions to Lead

V. Neurological Effects

VI. Hematological Effects

VII. Renal Effects

VIII. Effects of Lead on Reproduction and Development

IX. Effects on the Immune System

X. Interactions with Other Minerals

XI. Lead in Bone and Teeth

XII. Clinical Recognition of Lead Toxicity

XIII. Essentiality of Lead

XIV. Treatment of Lead Toxicity


5 Nickel

I. Introduction

II. Nickel Metabolism

III. Nickel Carbonyl Poisoning

IV. Nickel Carcinogenesis

V. Other Aspects of Nickel Toxicology

VI. Summary


6 Manganese

I. Introduction

II. Analyses of Mn in Biological Materials

III. Metabolism of Mn in Vitro

IV. Mn Requirements in Normal Nutrition

V. Absorption and Excretion of Mn

VI. Mn Turnover—Specificity

VII. Mn Deficiency

VIII. Mn Excess

IX. Susceptibility to Mn Poisoning

X. Conclusions and Summary


7 Chromium

I. Biological Role of Chromium in Mammals

II. Chromium Metabolism

III. Human Chromium Nutrition and Deficiency

IV. Concluding Remarks


8 Molybdenum

I. Introduction

II. Dietary Intake and Body Burden

III. Essentiality

IV. Biochemistry

V. Pharmacology

VI. Toxicity


9 Cadmium

I. Occurrence and Exposure

II. Review of Effects

III. Metabolism

IV. Cadmium-Induced Renal Damage

V. Effects on Vitamin D Metabolism

VI. Effects on Bones


10 Aluminum and Tin

I. Aluminum

II. Tin


11 Lithium

I. Chemistry

II. Biology

III. Pharmacokinetics

IV. Interactions of Lithium with Specific Homeostatic Systems


12 Fluoride

I. Introduction

II. Fluoride Intake

III. Absorption of Fluoride

IV. Distribution

V. Skeletal Deposition: Fluoride, A Bone Seeker

VI. Mobilization

VII. Excretion

VIII. Pregnancy and the Fetus

IX. Essentiality

X. Cyclic Adenosine Monophosphate

XI. Osteoporosis

XII. Otosclerosis

XIII. Some Toxic Fluoride Effects in Man

XIV. Organic Fluoride




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© Academic Press 1981
Academic Press
eBook ISBN:

About the Editor

Felix Bronner

Affiliations and Expertise

Department of Oral Biology, University of Connecticut Health Center

Jack W. Coburn

Ratings and Reviews