This book contains selected contributions of papers, many presented at the Second International Workshop on Neural Modeling of Brain Disorders, as well as a few additional papers on related topics, including a wide range of presentations describing computational models of neurological, neuropsychological and psychiatric disorders. It is a unique, comprehensive review of the state-of-the-art of modeling cognitive and brain disorders, appealing to a multidisciplinary audience of clinicians, psychologists, neuroscientists, cognitive scientists, computer scientists, and other neural network researchers.
The rest of the book is organized along four main themes, involving memory, neuropsychological, neurological and psychiatric disorders. In general, the cognitive disorders and these psychiatric diseases traditionally regarded as "functional" were modeled along functional lines, while those disorders traditionally viewed as "organic" neurological diseases generally drew more from knowledge of the underlying neurobiology and pathophysiology.

Table of Contents

List of contributors. Acknowledgements. Introduction: Understanding brain and cognitive disorders: the computational perspective (E. Ruppin, J.A. Reggia, D.L. Glanzman). I. Memory Disorders. 1. Neuromodulation and the hippocampus: memory function and dysfunction in a network simulation (M.E. Hasselmo). 2. Cholinergic neuromodulation and Alzheimer's disease: from single cells to network simulations (E.D. Menschik, L.H. Finkel). 3. Episodic memory in semantic dementia: a computational approach based on the TraceLink model (K.S. Graham, J.M.J. Murre, J.R. Hodges). 4. Multimodular networks and semantic memory impairments (D. Horn, N. Levy, E. Ruppin). II. Neuropsychology. 5. Understanding failures of learning: Hebbian learning, competition for representational space, and some preliminary experimental data (J.L. McClelland, A. Thomas, B.D. McCandliss, J.A. Fiez). 6. Frames of reference in hemineglect: a computational approach (A. Pouget, S. Deneve, T.J. Sejnowski). 7. Explaining object-based deficits in unilateral neglect without object-based frames of reference (M.C. Mozer). 8. Inter-hemispheric competition of sub-cortical structures is a crucial mechanism in paradoxical lesion effects and spatial neglect (C.-C. Hilgetag, R. Kötter, M.P. Young) 9. A new model of letter string encoding: simulating right neglect dyslexia (C. Whitney, R.S. Berndt). 10. Prosopagnosia in modular neural network models (M.N. Dailey, G.W. Cottrell). 11. Functional brain imaging and modeling of brain disorders (M.A. Tagamets, B. Horwitz). III. Neurology. 12. Unmasking unmasked: neural dynamics following stroke (W.W. Lytton, S.T. Williams, S.J. Sober). 13. Effects of callosal lesions in a computational model of single-word reading (J. Chhabra, M. Glezer, Y. Shku


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© 1999
Elsevier Science
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About the editors

J.A. Reggia

Affiliations and Expertise

University of Maryland, Departments of Computer Science and Neurology, UMIACS, College Park, MD 20742, USA

E. Ruppin

Affiliations and Expertise

Tel-Aviv University, Departments of Physiology and Computer Science, Schools of Medicine and Mathematics, Tel-Aviv 69978, Israel

D.L. Glanzman

Affiliations and Expertise

National Institute of Mental Health, The Neuroscience Centre, Theoretical and Computational Neuroscience Research Program, Bethesda, MD 20892, USA