Discovery and Development of Antidiabetic Agents from Natural Products - 1st Edition - ISBN: 9780128094501, 9780128096925

Discovery and Development of Antidiabetic Agents from Natural Products

1st Edition

Natural Product Drug Discovery

Authors: Goutam Brahmachari
eBook ISBN: 9780128096925
Paperback ISBN: 9780128094501
Imprint: Elsevier
Published Date: 25th October 2016
Page Count: 332
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Table of Contents

  • Dedication
  • List of Contributors
  • Editor Biography
  • Foreword
  • Preface
  • Chapter 1. Andrographolide: A Molecule of Antidiabetic Promise
    • 1. Introduction
    • 2. The Molecule
    • 3. Extraction, Purification, and Characterization Data of Andrographolide
    • 4. Total Synthesis of Andrographolide
    • 5. Antidiabetic Potential of Natural Andrographolide and Its Semisynthetic Derivatives
    • 6. Studies on Pharmacokinetics and Metabolism
    • 7. Safety Aspects of Andrographolide
    • 8. Concluding Remarks
    • List of Abbreviations
  • Chapter 2. Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products
    • 1. Introduction
    • 2. Computer-Aided Drug Design Methods
    • 3. Applications of Computation to Glycogen Phosphorylase Inhibitor Design
    • 4. Concluding Remarks
    • List of Abbreviations
  • Chapter 3. Identification and Extraction of Antidiabetic Antioxidants from Natural Sources
    • 1. Introduction
    • 2. Curcumin: Extraction, Identification, and Antidiabetic–Antioxidant Potential
    • 3. Mangiferin: Extraction, Identification, and Antidiabetic–Antioxidant Potential
    • 4. Arjunolic Acid: Extraction, Identification, and Antidiabetic–Antioxidant Potential
    • 5. Concluding Remarks
    • Abbreviations
  • Chapter 4. Glucose Transporter 4 Translocation Activators From Nature
    • 1. Introduction
    • 2. Plant Formulations With Glucose Transporter 4 Translocation Activity
    • 3. Naturally Occurring Compounds With GLUT4 Translocation Activity
    • 4. Natural Product Derivatives as GLUT4 Translocation Activators
    • 5. Concluding Remarks
    • List of Abbreviations
  • Chapter 5. Carbohydrate-Based Antidiabetic Agents From Nature
    • 1. Introduction
    • 2. Diabetes: Definition and Classification
    • 3. Importance of Carbohydrate in Antidiabetic Drug Development
    • 4. Glycosidase Inhibitors as Antidiabetic Agents
    • 5. Carbohydrate-Based Sodium Glucose Cotransporter 2 Inhibitors
    • 6. Other Important Carbohydrate-Based Antidiabetic Agents
    • 7. Concluding Remarks
    • List of Abbreviations
  • Chapter 6. Recent Developments on the Antidiabetic Sesquiterpene Lactones and Their Semisynthetic Analogues
    • 1. Introduction
    • 2. Plant-Derived Sesquiterpene Lactones With Antidiabetic Potential
    • 3. Plant Extracts Containing Sesquiterpene Lactone Molecules
    • 4. Structure–Activity Relationship of Sesquiterpene Lactones
    • 5. Concluding Remarks
    • List of Abbreviations
  • Chapter 7. Prediction of Prediabetes and Its Prevention by Functional Food Compounds
    • 1. Introduction
    • 2. Advanced Glycation End Products
    • 3. Inhibition of AGEs Accumulation by Natural Products
    • 4. The Prevention of Prediabetes by Natural Products
    • 5. Concluding Remarks
    • List of Abbreviations
  • Chapter 8. Immunomodulators in Prophylaxis and Therapy of Type-1 Diabetes
    • 1. Introduction
    • 2. Immune Modulators
    • 3. Other Options for Treatment and Prophylaxis of T1D
    • 4. Herbal Formulations in Market
    • 5. Advantages of Natural Immunomodulators
    • 6. Clinical Trials
    • 7. Concluding Remarks
    • List of Abbreviations
  • Chapter 9. α-Glucosidase Enzyme Inhibitors From Natural Products
    • 1. Introduction
    • 2. Brief Methodology, Characterization, and Identification of α-Glucosidase Inhibitors From Medicinal Plants
    • 3. Concluding Remarks
    • List of Abbreviations
  • Chapter 10. Treasures of Indigenous Indian Herbal Antidiabetics: An Overview
    • 1. Introduction
    • 2. Antidiabetic Indian Medicinal Plants
    • 3. Concluding Remarks
  • Index


Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic.

Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications.

Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics.

Key Features

  • Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery
  • Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues
  • Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab


Primarily medicinal chemists and researchers into antidiabetic drug design and drug leads from natural products, with a secondary audience of pharmacologists, biochemists and medical professionals involved in pre-clinical testing, clinical trials and application of antidiabetic drugs. Also of interest to post-grad and academic researchers in these fields


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About the Authors

Goutam Brahmachari Author

Professor Dr. Goutam Brahmachari was born at Barala in the district of Murshidabad (West Bengal), India, on April 14, 1969. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher secondary Education (WBCHSE). Then he moved to Visva-Bharati (a central university founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, Prof. Brahmachari completed his masters in 1992 with specialization in organic chemistry and thereafter received his PhD degree in 1997 in chemistry from the same university. He was appointed as assistant professor of organic chemistry in the Department of Chemistry, Visva-Bharati University, in 1998, and became associate professor in 2008. In 2011, he became full professor of organic chemistry in the same faculty. At present, he is responsible for teaching courses in organic chemistry, natural products chemistry, and physical methods in organic chemistry. Several students have received their PhD degree under the supervision of Prof. Brahmachari during this period, and a couple of research fellows are presently working with him both in the fields of natural products and synthetic organic chemistry. He serves as a member of the Indian Association for the Cultivation of Science (IACS) and Indian Science Congress Association (ISCA), Kolkata, and as an Editor-in-Chief, Signpost Open Access Journal of Organic and Biomolecular Chemistry. He also serves as an editorial advisory board member for several journals and is the Who’s Who in the World-2015 Listee. He is a recipient of the 3rd Academic Brilliance Award-2015 (Award for Excellence in Research).

Prof. Brahmachari’s research interests include (i) synthetic organic chemistry with special emphasis on green chemistry; (ii) isolation, structural determination, and/or detailed NMR study of new natural products from medicinal plants; (iii) semi-synthetic studies with natural products; and (iv) evaluation of biological activities and pharmacological potential of natural and synthetic compounds. With more than 16 years of teaching experience, he has produced so far nearly 120 scientific publications including original research papers, review articles, and invited book chapters in edited books in the field of natural products and organic synthesis from internationally reputed presses. Prof. Brahmachari has authored/edited a number of text and major reference books that include Organic Name Reactions: A Unified Approach (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2006), Chemistry of Natural Products: Recent Trends & Developments (Research Signpost, 2006), Organic Chemistry Through Solved Problems (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2007), Natural Products: Chemistry, Biochemistry and Pharmacology (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2009), Handbook of Pharmaceutical Natural Products—2 volume-set (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2010), Bioactive Natural Products: Opportunities & Challenges in Medicinal Chemistry (World Scientific Publishing Co. Pte. Ltd., Singapore, 2011), Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds (CRC Press, Taylor & Francis group, USA, 2013), Natural Bioactive Molecules: Impacts & Prospects (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2014), Green Synthetic Approaches for Biologically Relevant Heterocycles (Elsevier Inc., USA, 2014), and Bioactive Natural Products—Chemistry & Biology (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2015).

He is regularly consulted as a referee by leading international journals including Elsevier, Royal Society of Chemistry, American Chemical Society, Wiley, Taylor & Francis, Springer, Bentham Science, Indian Chemical Society, Pakistan Chemical Society, Korean Chemical Society, Brazilian Chemical Society, Bulgarian Academy of Sciences, and so on, and also various financial commissions.

Prof. Brahmachari enjoys Songs of Rabindranath Tagore and finds interests in Literature as well!

Affiliations and Expertise

Full Professor of Organic Chemistry, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan, West Bengal, India