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Discovery and Development of Antidiabetic Agents from Natural Products - 1st Edition - ISBN: 9780128094501, 9780128096925

Discovery and Development of Antidiabetic Agents from Natural Products

1st Edition

Natural Product Drug Discovery

Author: Goutam Brahmachari
Paperback ISBN: 9780128094501
eBook ISBN: 9780128096925
Imprint: Elsevier
Published Date: 25th October 2016
Page Count: 332
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Table of Contents

  • Dedication
  • List of Contributors
  • Editor Biography
  • Foreword
  • Preface
  • Chapter 1. Andrographolide: A Molecule of Antidiabetic Promise
    • 1. Introduction
    • 2. The Molecule
    • 3. Extraction, Purification, and Characterization Data of Andrographolide
    • 4. Total Synthesis of Andrographolide
    • 5. Antidiabetic Potential of Natural Andrographolide and Its Semisynthetic Derivatives
    • 6. Studies on Pharmacokinetics and Metabolism
    • 7. Safety Aspects of Andrographolide
    • 8. Concluding Remarks
    • List of Abbreviations
  • Chapter 2. Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products
    • 1. Introduction
    • 2. Computer-Aided Drug Design Methods
    • 3. Applications of Computation to Glycogen Phosphorylase Inhibitor Design
    • 4. Concluding Remarks
    • List of Abbreviations
  • Chapter 3. Identification and Extraction of Antidiabetic Antioxidants from Natural Sources
    • 1. Introduction
    • 2. Curcumin: Extraction, Identification, and Antidiabetic–Antioxidant Potential
    • 3. Mangiferin: Extraction, Identification, and Antidiabetic–Antioxidant Potential
    • 4. Arjunolic Acid: Extraction, Identification, and Antidiabetic–Antioxidant Potential
    • 5. Concluding Remarks
    • Abbreviations
  • Chapter 4. Glucose Transporter 4 Translocation Activators From Nature
    • 1. Introduction
    • 2. Plant Formulations With Glucose Transporter 4 Translocation Activity
    • 3. Naturally Occurring Compounds With GLUT4 Translocation Activity
    • 4. Natural Product Derivatives as GLUT4 Translocation Activators
    • 5. Concluding Remarks
    • List of Abbreviations
  • Chapter 5. Carbohydrate-Based Antidiabetic Agents From Nature
    • 1. Introduction
    • 2. Diabetes: Definition and Classification
    • 3. Importance of Carbohydrate in Antidiabetic Drug Development
    • 4. Glycosidase Inhibitors as Antidiabetic Agents
    • 5. Carbohydrate-Based Sodium Glucose Cotransporter 2 Inhibitors
    • 6. Other Important Carbohydrate-Based Antidiabetic Agents
    • 7. Concluding Remarks
    • List of Abbreviations
  • Chapter 6. Recent Developments on the Antidiabetic Sesquiterpene Lactones and Their Semisynthetic Analogues
    • 1. Introduction
    • 2. Plant-Derived Sesquiterpene Lactones With Antidiabetic Potential
    • 3. Plant Extracts Containing Sesquiterpene Lactone Molecules
    • 4. Structure–Activity Relationship of Sesquiterpene Lactones
    • 5. Concluding Remarks
    • List of Abbreviations
  • Chapter 7. Prediction of Prediabetes and Its Prevention by Functional Food Compounds
    • 1. Introduction
    • 2. Advanced Glycation End Products
    • 3. Inhibition of AGEs Accumulation by Natural Products
    • 4. The Prevention of Prediabetes by Natural Products
    • 5. Concluding Remarks
    • List of Abbreviations
  • Chapter 8. Immunomodulators in Prophylaxis and Therapy of Type-1 Diabetes
    • 1. Introduction
    • 2. Immune Modulators
    • 3. Other Options for Treatment and Prophylaxis of T1D
    • 4. Herbal Formulations in Market
    • 5. Advantages of Natural Immunomodulators
    • 6. Clinical Trials
    • 7. Concluding Remarks
    • List of Abbreviations
  • Chapter 9. α-Glucosidase Enzyme Inhibitors From Natural Products
    • 1. Introduction
    • 2. Brief Methodology, Characterization, and Identification of α-Glucosidase Inhibitors From Medicinal Plants
    • 3. Concluding Remarks
    • List of Abbreviations
  • Chapter 10. Treasures of Indigenous Indian Herbal Antidiabetics: An Overview
    • 1. Introduction
    • 2. Antidiabetic Indian Medicinal Plants
    • 3. Concluding Remarks
  • Index


Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic.

Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications.

Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics.

Key Features

  • Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery
  • Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues
  • Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab


Primarily medicinal chemists and researchers into antidiabetic drug design and drug leads from natural products, with a secondary audience of pharmacologists, biochemists and medical professionals involved in pre-clinical testing, clinical trials and application of antidiabetic drugs. Also of interest to post-grad and academic researchers in these fields


No. of pages:
© Elsevier 2017
25th October 2016
Paperback ISBN:
eBook ISBN:

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About the Author

Goutam Brahmachari

Goutam Brahmachari

Goutam Brahmachari is a professor of organic chemistry at Visva-Bharati, India, and teaches courses in organic chemistry, natural products chemistry, synthetic organic chemistry, and physical methods in organic chemistry. In addition to over 20 years of teaching and research experience, he is a Fellow of the Royal Society of Chemistry, a Who’s Who in the World Listee, and a recipient of Academic Brilliance Award (2015) for Excellence in Research and the Dr. Kalam Best Teaching Faculty Award (2017). Prof. Brahmachari serves as journal referee, editor-in-chief, associate editor, guest editor, and Editorial Advisory Board Member for several international journals, book publishers, and research funding agencies. He currently has 200 publications in the fields of organic and medicinal chemistry, including 22 books and over 40 book chapters, published by internationally reputed publishers.

Affiliations and Expertise

Full Professor of Organic Chemistry, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan, West Bengal, India